Quinacrine-induced dilation of the rat cecum and degeneration of large granular vesicle-containing neurons in the myenteric plexus

1985 ◽  
Vol 241 (2) ◽  
pp. 383-389 ◽  
Author(s):  
Tadahiko Iijima ◽  
Kazuo Hasegawa
Keyword(s):  
Myenteric Plexus ◽  
Granular Vesicle ◽  
Rat Cecum

Neurochemical phenotype and function of endomorphin-2-containing neurons in the myenteric plexus of the rat colon

2010 ◽  
Vol 34 (8) ◽  
pp. S19-S19
Author(s):  
Jun‑Ping Li ◽  
Chang‑Jun Gao ◽  
Bo‑Chang Lü ◽  
Ting Zhang ◽  
Jiang‑Bo Ma ◽  
...  
Keyword(s):  
Myenteric Plexus ◽  
Rat Colon ◽  
And Function

Sox2 expression in the myenteric plexus in the caecum of postnatal and adult mouse

2016 ◽  
Vol 54 (08) ◽  
Author(s):  
D Grundmann ◽  
E Loris ◽  
L Aigner ◽  
S Couillard-Despres ◽  
KH Schäfer
Keyword(s):  
Myenteric Plexus ◽  
Adult Mouse ◽  
Sox2 Expression

scholarly journals Dopamine Transporter Genetic Reduction Induces Morpho-Functional Changes in the Enteric Nervous System

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 465
Author(s):  
Silvia Cerantola ◽  
Valentina Caputi ◽  
Gabriella Contarini ◽  
Maddalena Mereu ◽  
Antonella Bertazzo ◽  
...  
Keyword(s):  
Nervous System ◽  
Small Intestine ◽  
Enteric Nervous System ◽  
Dopamine Transporter ◽  
Myenteric Plexus ◽  
Receptor Activation ◽  
D1 Receptor ◽  
Functional Changes ◽  
Neurochemical Coding ◽  
The Impact

Antidopaminergic gastrointestinal prokinetics are indeed commonly used to treat gastrointestinal motility disorders, although the precise role of dopaminergic transmission in the gut is still unclear. Since dopamine transporter (DAT) is involved in several brain disorders by modulating extracellular dopamine in the central nervous system, this study evaluated the impact of DAT genetic reduction on the morpho-functional integrity of mouse small intestine enteric nervous system (ENS). In DAT heterozygous (DAT+/−) and wild-type (DAT+/+) mice (14 ± 2 weeks) alterations in small intestinal contractility were evaluated by isometrical assessment of neuromuscular responses to receptor and non-receptor-mediated stimuli. Changes in ENS integrity were studied by real-time PCR and confocal immunofluorescence microscopy in longitudinal muscle-myenteric plexus whole-mount preparations (). DAT genetic reduction resulted in a significant increase in dopamine-mediated effects, primarily via D1 receptor activation, as well as in reduced cholinergic response, sustained by tachykininergic and glutamatergic neurotransmission via NMDA receptors. These functional anomalies were associated to architectural changes in the neurochemical coding and S100β immunoreactivity in small intestine myenteric plexus. Our study provides evidence that genetic-driven DAT defective activity determines anomalies in ENS architecture and neurochemical coding together with ileal dysmotility, highlighting the involvement of dopaminergic system in gut disorders, often associated to neurological conditions.

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