Genetic variation in transforming growth factor alpha: possible association of BamHI polymorphism with bilateral sporadic cleft lip and palate

1993 ◽  
Vol 92 (1) ◽  
pp. 81-82 ◽  
Author(s):  
C. Stoll ◽  
J. F. Qian ◽  
J. Feingold ◽  
P. Sauvage ◽  
E. May
Keyword(s):  
Genetic Variation ◽  
Growth Factor ◽  
Cleft Lip ◽  
Transforming Growth Factor ◽  
Cleft Lip And Palate ◽  
Transforming Growth Factor Alpha ◽  
Factor Alpha

No Evidence of Linkage for Cleft Lip with or without Cleft Palate to a Marker Near the Transforming Growth Factor Alpha Locus in Two Populations

1997 ◽  
Vol 47 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Diego F. Wyszynski ◽  
Nancy Maestri ◽  
Amy F. Lewanda ◽  
Iain McIntosh ◽  
Anne Smith ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Factor Alpha ◽  
Two Populations

Association between alleles of the transforming growth factor-alpha locus and the occurrence of cleft lip

1993 ◽  
Vol 45 (5) ◽  
pp. 565-569 ◽  
Author(s):  
Russell Sassani ◽  
Scott P. Bartlett ◽  
Hongshu Feng ◽  
Audrey Goldner-Sauve ◽  
Asifa K. Haq ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cleft Lip ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Alpha ◽  
Factor Alpha

Transforming Growth Factor Alpha Taq I Polymorphisms and Nonsyndromic Cleft Lip and/or Palate Risk

2018 ◽  
Vol 55 (6) ◽  
pp. 814-820 ◽  
Author(s):  
Chen Yan ◽  
He Deng-qi ◽  
Chen Li-ya ◽  
Yang Mang ◽  
Yang Ke-hu
Keyword(s):  
Growth Factor ◽  
Confidence Intervals ◽  
Odds Ratio ◽  
Cleft Lip ◽  
Transforming Growth Factor ◽  
Meta Analysis ◽  
Biomedical Literature ◽  
Transforming Growth Factor Alpha ◽  
Wild Type ◽  
Factor Alpha

Background: A series of epidemiological studies were conducted to investigate the association between transforming growth factor alpha ( TGFA) polymorphism and nonsyndromic cleft lip and/or palate (CL/P) risk, but the findings remain conflicting. The present meta-analysis summarizes the association between the TGFA Taq I polymorphisms and nonsyndromic CL/P risk. Methods: We searched PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature databases from their inception to May 1, 2015. Fixed-effects or random-effects models were used to calculate the pooled odds ratio for two genetic comparisons (heterozygous mutation versus wild type, homozygous mutation versus wild type). All of the statistical tests were conducted by STATA 10.0 (StataCorp, College Station, TX). Results: A total of 26 case-control studies were identified for this meta-analysis. There was evidence of a significant association between the TGFA Taq I polymorphism and nonsyndromic CL/P risk in the overall population. The TGFA polymorphism was associated with nonsyndromic CL/P susceptibility in Asian populations under any of genetic models. However, in subgroup analysis, we did not find a significant association of TGFA gene polymorphisms with a reduced cancer risk in White and other populations and (recessive model, odds ratio = 2.37, 95% confidence intervals = 0.92-6.07; odds ratio = 3.45, 95% confidence intervals = 1.07-11.09, respectively). Conclusion: Our study indicates that the TGFA gene polymorphism might be associated with nonsyndromic CL/P susceptibility. However, these findings still need to be confirmed by single, large, well-designed prospective studies.

Sign in / Sign up

Export Citation Format

Share Document