Serotonin in the brain of the goldfish, Carassius auratus

1983 ◽  
Vol 234 (2) ◽  
pp. 319-333 ◽  
Author(s):  
Olivier Kah ◽  
Pascal Chambolle
Keyword(s):  
Carassius Auratus ◽  
Goldfish Carassius Auratus ◽  
The Brain

In-vivo evaluation of dopamine receptor-mediated inhibition of gonadotrophin secretion from the pituitary gland of the goldfish, Carassius auratus

1987 ◽  
Vol 114 (3) ◽  
pp. 449-458 ◽  
Author(s):  
R. J. Omeljaniuk ◽  
S. H. Shih ◽  
R. E. Peter
Keyword(s):  
Dopamine Receptor ◽  
Carassius Auratus ◽  
Time Course ◽  
Dopamine Antagonists ◽  
Serum Concentrations ◽  
In Vivo Evaluation ◽  
Goldfish Carassius Auratus ◽  
Dopamine Receptor Antagonists ◽  
The Brain

ABSTRACT Dopamine acts directly on the pituitary to modulate gonadotrophin (GtH) secretion in goldfish (Carassius auratus). In the light of this important role for dopamine in the regulation of goldfish reproduction, this investigation was designed to evaluate the receptor specificity of this dopamine inhibition and to describe the use of domperidone, a specific dopamine D2-receptor antagonist, in the manipulation of pituitary function in goldfish. To investigate the specificity of dopamine inhibition of GtH secretion, selected dopamine receptor antagonists were injected i.p. to block dopamine receptors thereby increasing GtH secretion as reflected by increased serum concentrations of GtH. Serum GtH levels were significantly increased by the active stereoisomer (−)-sulpiride in a dose-related fashion; (+)-sulpiride had no effect. Comparison of dopamine antagonists at low doses indicated that only domperidone and pimozide caused significant increases in serum concentrations of GtH. Dopamine antagonists potentiated the action of a gonadotrophin-releasing hormone analogue (GnRH-A) with an order of potency of domperidone = pimozide > metoclopramide = fluphenazine. [3H]Domperidone, injected i.p. with unlabelled domperidone, entered the blood and achieved maximum concentrations 12 h after injection, but did not accumulate in the brain in appreciable amounts. Gonadal 3H radioactivity was usually equal to or in excess of blood radioactivity, while [3H]domperidone was highly concentrated in the pituitary in a time-dependent fashion, with maximal accumulation occurring 24 h after injection. The time-course of pituitary accumulation of [3H]domperidone correlated well with the temporal increase in serum GtH levels in response to i.p. injected domperidone or domperidone plus an analogue of LHRH. Domperidone increased serum concentrations of GtH in a dose-related fashion; an analogue of salmon GnRH (sGnRH-A) increased the sensitivity and magnitude of the serum GtH response to domperidone. Serum concentrations of GtH were increased by sGnRH-A in a dose-related fashion; a low dose of domperidone substantially increased the sensitivity of the serum GtH response to sGnRH-A. These results indicate that dopamine inhibits GtH secretion from the goldfish pituitary by acting through a specific mechanism mediated by a dopamine D2 receptor. Domperidone increased serum concentrations of GtH, potentiated the action of gonadotrophin-releasing hormones and did not pass into the brain after i.p. injection into goldfish. The data also suggest that dopamine and GnRH, although acting through different receptors, influence the effect of each other on GtH release. J. Endocr. (1987) 114, 449–458

Evidence of anoxia-induced channel arrest in the brain of the goldfish (Carassius auratus)

2008 ◽  
Vol 148 (4) ◽  
pp. 355-362 ◽  
Author(s):  
Michael P. Wilkie ◽  
Matthew E. Pamenter ◽  
Samir Alkabie ◽  
Dejana Carapic ◽  
Damian S.H. Shin ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Channel Arrest ◽  
Goldfish Carassius Auratus ◽  
The Brain

Some aspects of the fine structure of goldfish optic tectum

1978 ◽  
Vol 36 (2) ◽  
pp. 590-591
Author(s):  
Betty I. Roots
Keyword(s):  
Fine Structure ◽  
Optic Tectum ◽  
Phosphate Buffer ◽  
Carassius Auratus ◽  
Osmium Tetroxide ◽  
Uranyl Acetate ◽  
Lead Citrate ◽  
Goldfish Carassius Auratus ◽  
Laminar Pattern ◽  
The Brain

In teleosts the optic tectum is the major integrative centre in the brain. The cyto- and fibre architecture of the optic tectum have been studied extensively and a well-defined laminar pattern has been described. Here some aspects of the fine structure of the optic tectum of the goldfish, Carassius auratus, will be described and discussed. Goldfish which had been kept at a temperature of 15°C were fixed by perfusion with 2. 5% glutaraldehyde in a phosphate buffer. After fixation pieces of the optic tectum from both dorsal and ventral regions, cut so that their original orientation in the tectum could be determined by their shape, were removed. They were post-fixed in 1% osmium tetroxide in the same buffer for 1 1/2 h, dehydrated, stained in 2% uranyl acetate and embedded in epon. Sections were stained with lead citrate.Lining the ventrical is the ependyma consisting of epithelial-like cells which are 5. 4 μm in diameter, are ciliated, and joined by both desmosomes and tight junctions between their somata.

scholarly journals In Situ Localization and Rhythmic Expression of Ghrelin and ghs-r1 Ghrelin Receptor in the Brain and Gastrointestinal Tract of Goldfish (Carassius auratus)

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141043 ◽  
Author(s):  
Aída Sánchez-Bretaño ◽  
Ayelén M. Blanco ◽  
Suraj Unniappan ◽  
Olivier Kah ◽  
Marie-M. Gueguen ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Carassius Auratus ◽  
Ghrelin Receptor ◽  
Rhythmic Expression ◽  
Goldfish Carassius Auratus ◽  
The Brain
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