Restriction polymorphisms of the ceruloplasmin gene on chromosome 3

1995 ◽  
Vol 96 (2) ◽  
pp. 239-240 ◽  
Author(s):  
Muriel Bost ◽  
Mary Berkaw ◽  
O.Wesley McBride ◽  
Guy Chazot ◽  
Philippe Arnaud
Keyword(s):  
Chromosome 3 ◽  
Restriction Polymorphisms

Mapping of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chicken chromosome 3

2001 ◽  
Vol 32 (1) ◽  
pp. 50-50
Author(s):  
S. F. Ge ◽  
M. N. Romanov ◽  
P. J. Sharp ◽  
D. W. Burt ◽  
I. R. Paton ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Receptor Gene ◽  
Chromosome 3 ◽  
Chicken Chromosome

A Caution in Association of ABO Blood Group with COVID-19

2020 ◽  
Keyword(s):  
Gene Cluster ◽  
Clinical Outcomes ◽  
Blood Group ◽  
Association Analysis ◽  
Blood Type ◽  
Genome Wide Association ◽  
Chromosome 3 ◽  
Abo Blood Group ◽  
Genome Wide Association Analysis ◽  
Genome Wide

A comment on Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Association of ABO blood group and Covid19 susceptability. medRxiv [PREPRINT]. 2020; https://doi.org/10.1101/2020.03.11.20031096. Zeng X, Fan H, Lu D, Huang F, Meng X, Li Z, et al. Association between ABO blood group and clinical outcomes of Covid19. medRxiv[PREPRINT].2020; https://doi.org/10.1101/2020.04.15.20063107. Zietz M, Tatonetti N. Testing the association between blood type and COVID-19 infection, intubation, and death medRxiv [PREPRINT]. 2020; https://doi.org/10.1101/2020.04.08.20058073. Ellinghaus D, Degenhardt F, Bujanda L, al. e. The ABO blood group and a chromosome 3 gene cluster associate with SRAS-CoV2 respitarory failure in an Italy-Spain genome-wide association analysis. medRxiv. 2020; https://doi.org/10.1101/2020.05.31.20114991.

scholarly journals Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma

2021 ◽  
Vol 22 (13) ◽  
pp. 6727
Author(s):  
Svenja Mergener ◽  
Jens T. Siveke ◽  
Samuel Peña-Llopis
Keyword(s):  
Cell Lines ◽  
Uveal Melanoma ◽  
Survival Data ◽  
Translation Initiation Factor ◽  
The Cancer Genome Atlas ◽  
Initiation Factor ◽  
Chromosome 3 ◽  
Mek Inhibitors ◽  
Mek Inhibition ◽  
Insight Into

The use of MEK inhibitors in the therapy of uveal melanoma (UM) has been investigated widely but has failed to show benefits in clinical trials due to fast acquisition of resistance. In this study, we investigated a variety of therapeutic compounds in primary-derived uveal melanoma cell lines and found monosomy of chromosome 3 (M3) and mutations in BAP1 to be associated with higher resistance to MEK inhibition. However, reconstitution of BAP1 in a BAP1-deficient UM cell line was unable to restore sensitivity to MEK inhibition. We then compared UM tumors from The Cancer Genome Atlas (TCGA) with mutations in BAP1 with tumors with wild-type BAP1. Principal component analysis (PCA) clearly differentiated both groups of tumors, which displayed disparate overall and progression-free survival data. Further analysis provided insight into differential expression of genes involved in signaling pathways, suggesting that the downregulation of the eukaryotic translation initiation factor 2A (EIF2A) observed in UM tumors with BAP1 mutations and M3 UM cell lines might lead to a decrease in ribosome biogenesis while inducing an adaptive response to stress. Taken together, our study links loss of chromosome 3 with decreased sensitivity to MEK inhibition and gives insight into possible related mechanisms, whose understanding is fundamental to overcome resistance in this aggressive tumor.

scholarly journals CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

Genetics ◽  
1980 ◽  
Vol 94 (1) ◽  
pp. 115-133 ◽  
Author(s):  
Thomas C Kaufman ◽  
Ricki Lewis ◽  
Barbara Wakimoto
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Cytogenetic Analysis ◽  
Proximal Portion ◽  
Chromosome 3 ◽  
Gene Complex ◽  
Anterior Portion ◽  
Cytogenetic Evidence ◽  
The Right

ABSTRACT Cytogenetic evidence is presented demonstrating that the 84A-B interval in the proximal portion of the right arm of chromosome 3 is the residence of a homoeotic gene complex similar to the bithorax locus. This complex, originally defined by the Antennapedia (A n t p) mutation, controls segmentation in the anterior portion of the organism. Different lesions within this complex homoeotically transform portions OI the prothorax, proboscis, antenna and eye and present clear analogies to similar lesions within the bithorax locus.

scholarly journals THIRD-CHROMOSOME MUTAGEN-SENSITIVE MUTANTS OF DROSOPHILA MELANOGASTER

Genetics ◽  
1981 ◽  
Vol 97 (3-4) ◽  
pp. 607-623 ◽  
Author(s):  
J B Boyd ◽  
M D Golino ◽  
K E S Shaw ◽  
C J Osgood ◽  
M M Green
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Map ◽  
Nitrogen Mustard ◽  
Chromosome 3 ◽  
Methyl Methanesulfonate ◽  
Dna Metabolism ◽  
Genetic Analyses ◽  
Chemical Mutagens ◽  
Complementation Groups ◽  
Biochemical Analyses

ABSTRACT A total of 34 third chromosomes of Drosophila melanogaster that render homozygous larvae hypersensitive to killing by chemical mutagens have been isolated. Genetic analyses have placed responsible mutations in more than eleven complementation groups. Mutants in three complementation groups are strongly sensitive to methyl methanesulfonate, those in one are sensitive to nitrogen mustard, and mutants in six groups are hypersensitive to both mutagens. Eight of the ten loci mapped fall within 15% of the genetic map that encompasses the centromere of chromosome 3. Mutants from four of the complementation groups are associated with moderate to strong meiotic effects in females. Preliminary biochemical analyses have implicated seven of these loci in DNA metabolism.

scholarly journals Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19

2021 ◽  
Vol 117 ◽  
pp. 102595 ◽  
Author(s):  
Luca Valenti ◽  
Samantha Griffini ◽  
Giuseppe Lamorte ◽  
Elena Grovetti ◽  
Sara Colonia Uceda Renteria ◽  
...  
Keyword(s):  
Complement Activation ◽  
Chromosome 3

scholarly journals Dissection of closely linked QTLs controlling stigma exsertion rate in rice by substitution mapping

2021 ◽  
Author(s):  
Quanya Tan ◽  
Chengshu Wang ◽  
Xin Luan ◽  
Lingjie Zheng ◽  
Yuerong Ni ◽  
...  
Keyword(s):  
Complex Trait ◽  
Epistatic Effect ◽  
Open Reading Frames ◽  
Chromosome 3 ◽  
Chromosome 2 ◽  
Substitution Mapping ◽  
Mapping Strategy ◽  
Stigma Exsertion ◽  
Important Trait ◽  
Stigma Exsertion Rate

Abstract Key message Through substitution mapping strategy, two pairs of closely linked QTLs controlling stigma exsertion rate were dissected from chromosomes 2 and 3 and the four QTLs were fine mapped. Abstract Stigma exsertion rate (SER) is an important trait affecting the outcrossing ability of male sterility lines in hybrid rice. This complex trait was controlled by multiple QTLs and affected by environment condition. Here, we dissected, respectively, two pairs of tightly linked QTLs for SER on chromosomes 2 and 3 by substitution mapping. On chromosome 2, two linkage QTLs, qSER-2a and qSER-2b, were located in the region of 1288.0 kb, and were, respectively, delimited to the intervals of 234.9 kb and 214.3 kb. On chromosome 3, two QTLs, qSER-3a and qSER-3b, were detected in the region of 3575.5 kb and were narrowed down to 319.1 kb and 637.3 kb, respectively. The additive effects of four QTLs ranged from 7.9 to 9.0%. The epistatic effect produced by the interaction of qSER-2a and qSER-2b was much greater than that of qSER-3a and qSER-3b. The open reading frames were identified within the maximum intervals of qSER-2a, qSER-2b and qSER-3a, respectively. These results revealed that there are potential QTL clusters for SER in the two regions of chromosome 2 and chromosome 3. Fine mapping of the QTLs laid a foundation for cloning of the genes of SER.

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