Screening for naturally occurring apolipoprotein A-I variants: apo A-I(?K107) is associated with low HDL-cholesterol levels in men but not in women

1995 ◽  
Vol 96 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Jerzy-Roch Nofer ◽  
Arnold Eckardstein ◽  
Heiko Wiebusch ◽  
Wei Weng ◽  
Harald Funke ◽  
...  
Keyword(s):  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Naturally Occurring ◽  
Apolipoprotein A ◽  
Low Hdl

scholarly journals Tu-W16:3 Normal endothelial function in carriers of the apolipoprotein A-imilano mutant despite low HDL-cholesterol levels

2006 ◽  
Vol 7 (3) ◽  
pp. 152
Author(s):  
M. Gomaraschi ◽  
D. Baldassarre ◽  
M. Amato ◽  
S. Eligini ◽  
C.R. Sirtori ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Apolipoprotein A ◽  
Low Hdl

THE EFFECTS OF NICOTINIC ACID ON BLOOD LIPIDS IN PATIENTS WITH LOW HDL-CHOLESTEROL AND NORMAL TOTAL CHOLESTEROL LEVELS

1989 ◽  
Vol 9 (10) ◽  
pp. 414 ◽  
Author(s):  
R. W. Squire ◽  
G. T. Gau ◽  
B. A. Kottke ◽  
T. D. Miller ◽  
T. G. Allison ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Total Cholesterol ◽  
Blood Lipids ◽  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Low Hdl

scholarly journals A Novel Mutant, ApoA-I Nichinan (Glu235→0), Is Associated With Low HDL Cholesterol Levels and Decreased Cholesterol Efflux From Cells

1999 ◽  
Vol 19 (6) ◽  
pp. 1447-1455 ◽  
Author(s):  
Hua Han ◽  
Jun Sasaki ◽  
Akira Matsunaga ◽  
Hideki Hakamata ◽  
Wei Huang ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Low Hdl

scholarly journals Reduced risk of dyslipidaemia with oolong tea consumption: a population-based study in southern China

2013 ◽  
Vol 111 (8) ◽  
pp. 1421-1429 ◽  
Author(s):  
Deqing Yi ◽  
Xuerui Tan ◽  
Zhiguo Zhao ◽  
Yingmu Cai ◽  
Yiming Li ◽  
...  
Keyword(s):  
Southern China ◽  
Experimental Studies ◽  
Hdl Cholesterol ◽  
Black Tea ◽  
Population Based ◽  
Tea Consumption ◽  
Oolong Tea ◽  
Cholesterol Levels ◽  
Low Hdl ◽  
Biochemical Indices

Experimental studies have suggested that tea consumption could lower the risk of dyslipidaemia. However, epidemiological evidence is limited, especially in southern China, where oolong tea is the most widely consumed beverage. We conducted a population-based case–control study to evaluate the association between consumption of tea, especially oolong tea, and risk of dyslipidaemia in Shantou, southern China, from 2010 to 2011. Information on tea consumption, lifestyle characteristics and food consumption frequency of 1651 patients with newly diagnosed dyslipidaemia and 1390 controls was obtained using a semi-quantitative questionnaire. Anthropometric variables and serum biochemical indices were determined. Drinking more than 600 ml (2 paos) of green, oolong or black tea daily was found to be associated with the lowest odds of dyslipidaemia risk (P< 0·001) when compared with non-consumption, but only oolong tea consumption was found to be associated with low HDL-cholesterol levels. A dose–response relationship between duration of tea consumption and risk of dyslipidaemia (OR 0·10, 95 % CI 0·06, 0·16), as well as that between amount of dried tea leaves brewed and risk of dyslipidaemia (OR 0·34, 95 % CI 0·24, 0·48), was found. Moreover, consumption of oolong tea for the longest duration was found to be associated with 3·22, 11·99 and 6·69 % lower blood total cholesterol, TAG and LDL-cholesterol levels, respectively. In conclusion, the present study indicates that long-term oolong tea consumption may be associated with a lower risk of dyslipidaemia in the population of Shantou in southern China.

Abstract 104: Serum from Patients with Aortic Valvular Stenosis Shows Decreased Cholesterol Efflux Capacities Despite Similar High-Density Lipoprotein Cholesterol Levels

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Benoit J Arsenault ◽  
Mathieu R Brodeur ◽  
David Rhainds ◽  
Anne-Elen Kernaleguen ◽  
Véronique Lavoie ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Pearson Correlation ◽  
Hdl Cholesterol ◽  
P Value ◽  
Aortic Valvular Stenosis ◽  
Cholesterol Efflux Capacity ◽  
Cholesterol Levels ◽  
Apolipoprotein A ◽  
Valvular Stenosis ◽  
Jet Velocity

Background: Studies have shown that low HDL-cholesterol levels may be associated with the progression of aortic valvular calcium and aortic valvular stenosis (AVS), but whether patients with AVS have impaired cholesterol efflux capacities is unknown. Methods and results: We have measured four parameters of cholesterol efflux capacity in apolipoprotein B-depleted serum samples from 48 patients with (aortic jet velocity ≥2.5 m/s, mean age = 72 ± 7 years and 72.7% men) and 51 patients without AVS (aortic jet velocity ≤ 1.7 m/s, mean age 71 ± 7 years and 70.6% men). Cholesterol efflux capacity was measured using J774 macrophages with and without stimulation of ABCA1 expression by cAMP (non-stimulated efflux, total efflux and ABCA1-mediated efflux), and HepG2 hepatocytes to measure SR-BI-mediated efflux. Mean HDL-cholesterol and apolipoprotein A-I levels as well as efflux are shown in the table for patients with vs. without AVS. The Pearson correlation coefficient between HDL-cholesterol levels and SR-B1-dependent efflux was 0.39 (p=0.007) in patients with AVS and 0.68 (<0.0001) in controls (P-value for the difference between the correlation coefficients obtained with Fisher’s test = 0.04). Conclusions: This study provides evidence that serum from patients with AVS may have impaired cholesterol efflux capacities, especially through the SR-B1 pathway. Table. Mean HDL-cholesterol and apolipoprotein A-I levels as well as non-stimulated-, total-, ABCA1-, and SR-B1-dependent cholesterol efflux obtained from patients’ serum with vs. without AVS. Data is shown as mean ± SD. Differences between categories were assessed using a Student unpaired t-test.

A novel nonsense apolipoprotein A-I mutation (apoA-IE136X) causes low HDL cholesterol in French Canadians

2006 ◽  
Vol 185 (1) ◽  
pp. 127-136 ◽  
Author(s):  
Zari Dastani ◽  
Carole Dangoisse ◽  
Betsie Boucher ◽  
Katia Desbiens ◽  
Larbi Krimbou ◽  
...  
Keyword(s):  
Hdl Cholesterol ◽  
French Canadians ◽  
Apolipoprotein A ◽  
Low Hdl
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