Peripheral T? lymphocyte population in head and neck cancer

1984 ◽  
Vol 17 (3) ◽  
Author(s):  
Yoshio Hayashi ◽  
Toshinobu Nishida ◽  
Hideo Yoshida ◽  
Tetsuo Yanagawa ◽  
Yoshiaki Yura ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
T Lymphocyte ◽  
Neck Cancer ◽  
Lymphocyte Population

scholarly journals Peripheral k-lymphocyte population in head and neck cancer

Cancer ◽  
1984 ◽  
Vol 53 (11) ◽  
pp. 2507-2514 ◽  
Author(s):  
Yoshio Hayashi Dds ◽  
Toshinobu Nishida ◽  
Hideo Yoshida Dds ◽  
Tetsuo Yanagawa ◽  
Yoshiaki Yura ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Lymphocyte Population

In vitro T-lymphocyte function in head and neck cancer patients

1997 ◽  
Vol 254 (7) ◽  
pp. 318-322 ◽  
Author(s):  
J. H. Heimdal ◽  
H. J. Aarstad ◽  
A. Aakvaag ◽  
J. Olofsson
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
T Lymphocyte ◽  
Neck Cancer ◽  
Lymphocyte Function

Cellular immune defect caused by postsurgical radiation therapy in patients with head and neck cancer

1998 ◽  
Vol 119 (4) ◽  
pp. 412-417 ◽  
Author(s):  
Matthias Tisch ◽  
Florίan Heimlich ◽  
Volker Daniel ◽  
Gerhard Opelz ◽  
Heinz Maier
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
T Lymphocyte ◽  
Neck Cancer ◽  
Cellular Immunity ◽  
Lymphocyte Count ◽  
Radiation Treatment ◽  
Lymphocyte Stimulation

The effects of locoregional postoperative radiation therapy (60 Gy on average) on cellular immunity were investigated in 11 patients with squamocellular carcinomas of the oral cavity, pharynx, or larynx. During radiation treatment, the total lymphocyte counts, CD8+ T-lymphocyte count, and especially CD4+ T-lymphocyte count decreased significantly. The mean CD4+ T-lymphocyte counts dropped from an average of 739/μl to 183/μl ( p <0.001), and the CD4+/CD8+ quotient also decreased significantly. Not only the lymphocyte counts but also the in vitro lymphocyte stimulation responses to several mitogens decreased, with reductions averaging 10% to 50% of normal responses by the end of radiation therapy. Within 3 to 4 weeks after radiation therapy, the CD4+ T-lymphocyte counts and the in vitro lymphocyte stimulation responses showed a tendency toward normalization. This study shows that postoperative locoregional radiation therapy in patients with head and neck cancer induces a severe generalized impairment of cellular immunity.

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