Deletion mapping of interval 6 of the human Y chromosome

1991 ◽  
Vol 87 (2) ◽  
pp. 234-236 ◽  
Author(s):  
Maciej Kotecki ◽  
Jadwiga Jaruzelska ◽  
Malgorzata Skowrońska ◽  
Piotr Fichna

This paper reviews past and present trends in mapping the human Y chromosome. So far, mapping has essentially used a combination of cytogenetic and molecular analyses of Y-chromosomal anomalies and sex reversal syndromes. This deletion mapping culminated recently in the isolation of the putative sex-determining locus TDF . With the availability of new separation and cloning techniques suited for large size fragments (over 100 kilobases), the next step will consist rather in the establishment of a physical map of fragments of known physical sizes. This may allow the definition of several variants of the human Y chromosome differing by the order or location of DNA sequences along the molecule.


Genomics ◽  
1992 ◽  
Vol 13 (4) ◽  
pp. 1255-1260 ◽  
Author(s):  
Michael A. Cantrell ◽  
Jonathan S. Bogan ◽  
Elizabeth Simpson ◽  
James N. Bicknell ◽  
Els Goulmy ◽  
...  

1995 ◽  
Vol 7 (4) ◽  
pp. 685 ◽  
Author(s):  
PH Vogt ◽  
A Edelmann ◽  
P Hirschmann ◽  
MR Kohler

Different Y mutations in Yq11 occurring de novo in sterile males were first described 19 years ago. Since the phenotype of the patients was always associated with azoospermia or severe oligospermia, it was postulated that these mutations interrupt a Y spermatogenesis locus in the euchromatic Y region (Yq11) called azoospermia factor (AZF). Recently, it became possible to map AZF mutations to different subregions in Yq11 by molecular deletion mapping. This indicated that azoospermia is possibly caused by more than one Y gene in Yq11 and the Yq11 chromatin structure. The frequency of AZF mutations in idiopathic sterile males (5-20%) may indicate a need for a general screening programme for its analysis in infertility clinics.


2004 ◽  
Vol 24 (2) ◽  
pp. 308-312 ◽  
Author(s):  
Fadi J. Charchar ◽  
Maciej Tomaszewski ◽  
Beata Lacka ◽  
Jaroslaw Zakrzewski ◽  
Ewa Zukowska-Szczechowska ◽  
...  

2002 ◽  
Vol 70 (5) ◽  
pp. 1197-1214 ◽  
Author(s):  
Fulvio Cruciani ◽  
Piero Santolamazza ◽  
Peidong Shen ◽  
Vincent Macaulay ◽  
Pedro Moral ◽  
...  

1988 ◽  
Vol 79 (1) ◽  
pp. 36-38 ◽  
Author(s):  
M. S. Lin ◽  
A. Zhang ◽  
M. G. Wilson ◽  
A. Fujimoto

Lab Animal ◽  
2012 ◽  
Vol 41 (4) ◽  
pp. 89-89
Author(s):  
Monica Harrington

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