Antitumor activity of Nocardia cell wall skeleton preparations in transplantable tumors in syngeneic mice and patients with malignant pleurisy

1978 ◽  
Vol 4 (2) ◽  
Author(s):  
Ichiro Azuma ◽  
Mikio Yamawaki ◽  
Kosei Yasumoto ◽  
Yuichi Yamamura
Keyword(s):  
Cell Wall ◽  
Antitumor Activity ◽  
Transplantable Tumors ◽  
Malignant Pleurisy

Antitumor acridines with diaminoalkylo pharmacophoric group

2001 ◽  
Vol 73 (9) ◽  
pp. 1421-1428 ◽  
Author(s):  
Jerzy Konopa
Keyword(s):  
Clinical Trials ◽  
Biological Activity ◽  
Antitumor Activity ◽  
Clinical Evaluation ◽  
Wide Spectrum ◽  
Aromatic Rings ◽  
Transplantable Tumors

The substitution of acridine molecule in positions 1 and/or 4 with diaminoalkylo residue may result in obtaining derivatives displaying antitumor activity. The diaminoalkylo residue can be attached to acridine either directly or indirectly as a carboxamido moiety. In the former case, the presence of appropriate substituent in position para to diaminoalkylo residue is crucial for antitumor activity. Also, heterocyclic aromatic rings condensed with the acridine core can be considered as such substituents. Additional substituents introduced into the acridine core, especially those that may be transformed into quinoid systems, significantly increase antitumor activity of modified analogs. It is, however, of utmost importance that the presence of diaminoalkylo residue is the indispensable prerequisite for biological activity of acridines. Among several groups of synthesized diaminoalkyloacridines, the most potent antineoplastic properties toward a wide spectrum of transplantable tumors are exhibited by acridine-4-carboxamides, imidazo-, triazolo-, and pyrazoloacridinones. Two derivatives belonging to the above groups, acridine-4-carboxamide DACA and imidazoacridinone C-1311, are currently in clinical trials. Other derivatives exhibiting potent antitumor activity, that could be considered as close analogs of diaminolkyloacridines, are pyrazoloacridines, one of which is currently under clinical evaluation.

THE EFFECTS OF THE COMBINATION OF RAPAMYCIN WITH DOXORUBICIN AND PACLITAXEL ON THE MODELS OF TRANSPLANTABLE TUMORS IN MICE

2019 ◽  
Vol 65 (4) ◽  
pp. 614-622
Author(s):  
Mariya Yurova ◽  
Margarita Tyndyk ◽  
Yekaterina Gubareva ◽  
Yelena Fedoros ◽  
Viktor Anisimov
Keyword(s):  
Antitumor Activity ◽  
Protective Effect ◽  
Total Dose ◽  
Mtor Inhibitor ◽  
Combined Treatment ◽  
Mammary Adenocarcinoma ◽  
Ehrlich Carcinoma ◽  
Tumor Growth Inhibition ◽  
Chemotherapeutic Drugs ◽  
Transplantable Tumors

The study aimed to assess combined treatment with mTOR inhibitor rapamycin and cytotoxic drugs (doxorubicin and paclitaxel) on two models of transplantable tumors - mammary adenocarcinoma in male HER-2/neu transgenic FVB/N mice and solid Ehrlich carcinoma in male 129/Sv mice. Rapamycin (total dose of 3.6 mg kg), doxorubicin (total dose of 15 mg/ kg), paclitaxel (total dose of 6 mg/kg) or their combination were intraperitoneally injected to mice with developed tumor node. Rapamycin showed its own antitumor activity by tumor growth inhibition up to 42% in mammary adenocarcinoma model and up to 57% in Ehrlich carcinoma model. A tendency to an increase in the antitumor activity of chemotherapeutic drugs with the addition of rapamycin was revealed. The cyto-protective effect of the mTOR inhibitor was observed during therapy with doxorubicin and paclitaxel, expressed in a significant decrease in the level of apoptosis in normal epithelium of jejunum crypts. Thus, revealed protective effect of mTOR inhibitor on jejunum epithelium could be applied for reduction of chemotherapeutic drugs enterotoxic effect without any efficiency reduction. Thus, in perspective that could expand the possibilities of standard chemotherapeutic treatment and improve the quality of life of cancer patients.

scholarly journals Antitumor activity of cell wall from Streptoverticillium cinnamoneum.

1984 ◽  
Vol 32 (2) ◽  
pp. 786-790 ◽  
Author(s):  
YOSHIO OKAWA ◽  
KAZUHIKO HASHIMOTO ◽  
KO SUZUKI ◽  
SHIGEO SUZUKI ◽  
MASUKO SUZUKI
Keyword(s):  
Cell Wall ◽  
Antitumor Activity

scholarly journals Immunological Studies on Antitumor Activity of Yeast Cell Wall. I. The Antitumor Activity and Its Effects by Immunosuppression

1978 ◽  
Vol 98 (8) ◽  
pp. 1028-1034
Author(s):  
TADAYORI SHIMIZU ◽  
SOICHI HARAGUCHI ◽  
ICHIJI MIFUCHI ◽  
MASAYASU NAKANO
Keyword(s):  
Cell Wall ◽  
Antitumor Activity ◽  
Yeast Cell ◽  
Yeast Cell Wall

scholarly journals Experimental Study of the Antitumor Activity of Polymetalacrylates against Animal Transplantable Tumors

2010 ◽  
Vol 01 (02) ◽  
pp. 59-65 ◽  
Author(s):  
Larisa A. Ostrovskaya ◽  
M. G. Voronkov ◽  
D. B. Korman ◽  
M. M. Fomina ◽  
N. V. Bluhterova ◽  
...  
Keyword(s):  
Experimental Study ◽  
Antitumor Activity ◽  
Transplantable Tumors
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