Interactive effects of cadmium and retinoic acid on mouse limb bud development in vitro

1994 ◽  
Vol 53 (4) ◽  
Author(s):  
T. Shury ◽  
C.G. Rousseaux ◽  
J. Keiner ◽  
M. Politis
Keyword(s):  
Retinoic Acid ◽  
Limb Bud ◽  
Interactive Effects ◽  
Bud Development ◽  
Mouse Limb ◽  
Development In Vitro

Vitamin A alters the internal viscosity of fragments of limb-bud mesenchyme

Development ◽  
1980 ◽  
Vol 59 (1) ◽  
pp. 325-339
Author(s):  
T. E. Kwasigroch ◽  
D. M. Kochhar
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Mesenchymal Cells ◽  
Limb Bud ◽  
Mouse Limb ◽  
Vitamin A Acid ◽  
Internal Viscosity ◽  
Fusion Experiments

Two techniques were used to examine the effect of vitamin A compounds (vitamin A acid = retinoic acid and vitamin A acetate) upon the relative strengths of adhesion among mouse limb-bud mesenchymal cells. Treatment with retinoic acid in vivo and with vitamin A acetate in vitro reduced the rate at which the fragments of mesenchyme rounded-up when cultured on a non-adhesive substratum, but these compounds did not alter the behavior of tissues tested in fragment-fusion experiments. These conflicting results indicate that the two tests measure different activities of cells and suggest that treatment with vitamin A alters the property(ies) of cells which regulate the internal viscosity of tissues.

Mouse limb bud cells respond to retinoic acid in vitro with reduced growth

1992 ◽  
Vol 263 (4) ◽  
pp. 406-413 ◽  
Author(s):  
D. M. Gardiner ◽  
C. Gaudier ◽  
S. V. Bryant
Keyword(s):  
Retinoic Acid ◽  
Limb Bud ◽  
Mouse Limb

mRNA expression patterns of the IGF system during mouse limb bud development, determined by whole mount in situ hybridization

1998 ◽  
Vol 138 (1-2) ◽  
pp. 151-161 ◽  
Author(s):  
Marjolein van Kleffens ◽  
Cora Groffen ◽  
Roberto R. Rosato ◽  
Stefan M. van den Eijnde ◽  
Johan W. van Neck ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Mrna Expression ◽  
Expression Patterns ◽  
Limb Bud ◽  
Bud Development ◽  
Igf System ◽  
Whole Mount ◽  
Mouse Limb

Chondrogenesis in mouse limb bud in vitro. I. Effect of the ectoderm

1985 ◽  
Vol 55 (1-2) ◽  
pp. 113-123 ◽  
Author(s):  
X. Desbiens ◽  
F. Carette ◽  
L. Meunier ◽  
A. Bart
Keyword(s):  
Limb Bud ◽  
Mouse Limb

scholarly journals Genetics and functions of the retinoic acid pathway, with special emphasis on the eye

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Brian Thompson ◽  
Nicholas Katsanis ◽  
Nicholas Apostolopoulos ◽  
David C. Thompson ◽  
Daniel W. Nebert ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Embryonic Development ◽  
Normal Development ◽  
Anterior Segment ◽  
Limb Bud ◽  
Optic Vesicle ◽  
Bud Development ◽  
Optic Cup ◽  
Multistep Process ◽  
Acid Pathway

AbstractRetinoic acid (RA) is a potent morphogen required for embryonic development. RA is formed in a multistep process from vitamin A (retinol); RA acts in a paracrine fashion to shape the developing eye and is essential for normal optic vesicle and anterior segment formation. Perturbation in RA-signaling can result in severe ocular developmental diseases—including microphthalmia, anophthalmia, and coloboma. RA-signaling is also essential for embryonic development and life, as indicated by the significant consequences of mutations in genes involved in RA-signaling. The requirement of RA-signaling for normal development is further supported by the manifestation of severe pathologies in animal models of RA deficiency—such as ventral lens rotation, failure of optic cup formation, and embryonic and postnatal lethality. In this review, we summarize RA-signaling, recent advances in our understanding of this pathway in eye development, and the requirement of RA-signaling for embryonic development (e.g., organogenesis and limb bud development) and life.

scholarly journals SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling

Development ◽  
2011 ◽  
Vol 138 (10) ◽  
pp. 1913-1923 ◽  
Author(s):  
S. Probst ◽  
C. Kraemer ◽  
P. Demougin ◽  
R. Sheth ◽  
G. R. Martin ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Limb Bud ◽  
Distal Limb ◽  
Bud Development ◽  
Acid Clearance ◽  
Fgf Signalling

Development in vitro of excised flower primordia of Nicotiana tabacum

1970 ◽  
Vol 48 (1) ◽  
pp. 133-139 ◽  
Author(s):  
G. S. Hicks ◽  
I. M. Sussex
Keyword(s):  
Nicotiana Tabacum ◽  
Normal Embryo ◽  
Flower Primordia ◽  
Bud Development ◽  
Flower Morphogenesis ◽  
Bud Growth ◽  
Specific Regulation ◽  
Development In Vitro ◽  
Normal Flower

Young flower primordia of Nicotiana tabacum 'Wisconsin 38' have been successfully cultured on a nutrient medium supplemented with kinetin. The petal, stamen, and carpel primordia form in the normal acropetal sequence during the first week on excised floral apices which initially bore only sepal primordia. Relatively normal morphogenesis of the organs ensues, and on optimal concentrations of kinetin, pedicel length, calyx length and width, corolla width, and ovary length and width after 4 weeks were comparable to those in the normal flower at anthesis. The corolla, filaments, and style were always much shorter than normal. Large quantities of pollen were produced on low kinetin concentrations and normal embryo sacs formed in the numerous ovules. When kinetin was omitted from the medium, similar explants initiated all the organ primordia, but these subsequently remained minute through 4 weeks of culture. The data indicate that organ initiation is independent of exogenously supplied hormones, but that the later phases of bud growth have a marked requirement for kinetin. It is suggested that the sepals or petals may provide some stimulus for the initiation of meiosis in the anthers and ovules. In that flower morphogenesis in culture is independent of specific regulation from the rest of the plant, bud development appears to be relatively autonomous.

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