Evidence against heterozygous coagulation factor V 1691 G?A mutation with resistance to activated protein C being a risk factor for coronary artery disease and myocardial infarction

1995 ◽  
Vol 73 (10) ◽  
Author(s):  
W. Prohaska ◽  
H. Mannebach ◽  
M. Schmidt ◽  
U. Gleichmann ◽  
K. Kleesiek
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Protein C ◽  
Activated Protein C ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V ◽  
Artery Disease

Mutation in coagulation factor V associated with resistance to activated protein C in patients with coronary artery disease

The Lancet ◽  
1995 ◽  
Vol 345 (8948) ◽  
pp. 526-527 ◽  
Author(s):  
W. Marz ◽  
H. Seydewitz ◽  
B. Winkelmann ◽  
M. Chen ◽  
M. Nauck ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Protein C ◽  
Activated Protein C ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V ◽  
Artery Disease

Coagulation Factor V Leiden Mutation Was Detected in the Patients with Activated Protein C Resistance in Thailand

1998 ◽  
Vol 80 (08) ◽  
pp. 344-345 ◽  
Author(s):  
Pasra Arnutti ◽  
Motofumi Hiyoshi ◽  
Wichai Prayoonwiwat ◽  
Oytip Nathalang ◽  
Chamaiporn Suwanasophon ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Coagulation Factor V

Prospective Analysis after Coronary-artery Bypass Grafting: Platelet GP IIIa Polymorphism (HPA-1b /PlA2) Is a Risk Factor for Bypass Occlusion, Myocardial Infarction, and Death

2000 ◽  
Vol 83 (03) ◽  
pp. 404-407 ◽  
Author(s):  
Michael Klein ◽  
Hans Dauben ◽  
Christiane Moser ◽  
Emmeran Gams ◽  
Rüdiger Scharf ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Odds Ratio ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Hereditary Risk ◽  
Artery Disease

SummaryRecently, we have demonstrated that human platelet antigen 1b (HPA-1b or PlA2) is a hereditary risk factor for platelet thrombogenicity leading to premature myocardial infarction in preexisting coronary artery disease. However, HPA-1b does not represent a risk factor for coronary artery disease itself. The aim of our present study was to evaluate the role of HPA-1b on the outcome in patients after coronaryartery bypass surgery. We prospectively determined the HPA-1 genotype in 261 consecutive patients prior to saphenous-vein coronaryartery bypass grafting. The patients were followed for one year. Among patients with bypass occlusion, myocardial infarction, or death more than 30 days after surgery, the prevalence of HPA-1b was significantly higher than among patients without postoperative complications (60 percent, 6/10, vs. 24 percent, 58/241, p <0.05, odds ratio 4.7). Using a stepwise logistic regression analysis with the variables HPA1b, age, sex, body mass index, smoking (pack-years), hypertension, diabetes, cholesterol and triglyceride concentration, only HPA-1b had a significant association with bypass occlusion, myocardial infarction, or death after bypass surgery (p = 0.019, odds ratio 4.7). This study shows that HPA-1b is a hereditary risk factor for bypass occlusion, myocardial infarction, or death in patients after coronary-artery bypass surgery.

Molecular Detection of a Common Mutation in Coagulation Factor V Causing Thrombosis via Hereditary Resistance to Activated Protein C

1995 ◽  
Vol 4 (3) ◽  
pp. 191-197 ◽  
Author(s):  
Xiao-Yuan Liu ◽  
Diana Nelson ◽  
Chris Grant ◽  
Virginia Morthland ◽  
Scott H. Goodnight ◽  
...  
Keyword(s):  
Protein C ◽  
Molecular Detection ◽  
Activated Protein C ◽  
Coagulation Factor ◽  
Common Mutation ◽  
Factor V ◽  
Coagulation Factor V
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