Bile duct hyperplasia and transient liver parenchymal cell alteration by methylisocyanate

1993 ◽  
Vol 51 (2) ◽  
Author(s):  
Usha Arora ◽  
R. Vijayaraghavan ◽  
K. Sugendran ◽  
R. Mathur
Keyword(s):  
Bile Duct ◽  
Parenchymal Cell ◽  
Liver Parenchymal Cell ◽  
Liver Parenchymal

Regulation of pyruvate kinase by 6-phosphogluconate in isolated hepatocytes

1981 ◽  
Vol 240 (3) ◽  
pp. E279-E285
Author(s):  
S. B. Smith ◽  
R. A. Freedland
Keyword(s):  
Pyruvate Kinase ◽  
Parenchymal Cell ◽  
Isolated Hepatocytes ◽  
Hill Coefficient ◽  
Liver Parenchymal Cell ◽  
Liver Parenchymal ◽  
Highly Correlated ◽  
Parenchymal Cells ◽  
The Hill ◽  
Isolated Liver

Isolated liver parenchymal cells from rats fed a 65% sucrose diet for 14 days were incubated in the presence and absence of 10(-6) M glucagon. The pyruvate kinase obtained from homogenates of the glucagon-treated cells displayed and increased Ks 0.5 for phosphoenolpyruvate (P-enolpyruvate), as well as an increased Ka 0.5 for 6-phosphogluconate (6-P-gluconate), compared to pyruvate kinase from untreated cells. Additionally, glucagon treatment decreased the maximal stimulation of pyruvate kinase by 6-P-gluconate by approximately two-thirds and decreased the Hill coefficient value of pyruvate kinase for 6-P-gluconate from 1.76 to 1.56. 6-Aminonicotinamide, an inhibitor of 6-P-gluconate dehydrogenase, increased 6-P-gluconate levels in isolated liver parenchymal cells three- to sevenfold, depending on the substrates present. The flux of P-enolpyruvate through pyruvate kinase was increased from 18 to 40% in these preparations and was highly correlated with the increase in 6-P-gluconate levels. The results suggest that 6-P-gluconate could regulate pyruvate kinase activity in the intact liver parenchymal cell. Furthermore, the activator would be of greatest importance in the lipogenic animal.

l-Thyroxine enters the rat liver cell by simple diffusion

1983 ◽  
Vol 97 (2) ◽  
pp. 277-282 ◽  
Author(s):  
G. S. Rao ◽  
M. L. Rao
Keyword(s):  
Rat Liver ◽  
Arrhenius Plot ◽  
Parenchymal Cell ◽  
Liver Cells ◽  
Liver Parenchymal Cell ◽  
Simple Diffusion ◽  
Liver Parenchymal ◽  
Isolated Rat Liver ◽  
Centrifugation Technique ◽  
Parenchymal Cells

The mode of uptake of l-[125I]thyroxine by freshly isolated rat liver parenchymal cells was studied by a rapid centrifugation technique. Using conditions for measuring initial rates of uptake, uptake by liver cells was not saturable when exposed to hormone concentrations in the incubation medium ranging from 2 pmol/l to 10 μmol/l. The Arrhenius plot was linear from 2 to 37°C; the temperature coefficient was 1·4. The uptake of l-[125I]thyroxine by liver cells was 35% when compared with that of l-[125I]tri-iodothyronine. In the presence of 2·8% bovine serum albumin the rate of uptake of l-[125I]thyroxine by liver cells was reduced by 90%. These results suggest that l-[125I]thyroxine enters the rat liver parenchymal cell by simple diffusion and only the free hormone crosses the plasma membrane.

scholarly journals Active Synthesis of Collagen by Albumin-Producing Liver Parenchymal Cell Clones in Culture

1978 ◽  
Vol 54 (7) ◽  
pp. 391-396 ◽  
Author(s):  
Ryu-ichiro HATA ◽  
Yoshifumi NINOMIYA ◽  
Yutaka NAGAI ◽  
Kooko SAKAKIBARA ◽  
Yutaka TSUKADA
Keyword(s):  
Parenchymal Cell ◽  
Active Synthesis ◽  
Liver Parenchymal Cell ◽  
Liver Parenchymal ◽  
Cell Clones

Penicillamine induced changes in growing rats. II. liver parenchymal cell

1971 ◽  
Vol 27 (7) ◽  
pp. 794-797 ◽  
Author(s):  
U. N. Riede ◽  
M. Roth ◽  
J. J. Molar ◽  
L. Bianchi ◽  
H. P. Rohr
Keyword(s):  
Parenchymal Cell ◽  
Liver Parenchymal Cell ◽  
Liver Parenchymal ◽  
Growing Rats ◽  
Induced Changes

scholarly journals Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout

2014 ◽  
Vol 21 (11) ◽  
pp. 1721-1732 ◽  
Author(s):  
H Ehlken ◽  
S Krishna-Subramanian ◽  
L Ochoa-Callejero ◽  
V Kondylis ◽  
N E Nadi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Parenchymal Cell ◽  
Death Receptor ◽  
Liver Parenchymal Cell ◽  
Liver Parenchymal
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