Effects of ?-chloroacetophenone (CN) vapor inhalation on pulmonary immune system of mice

1993 ◽  
Vol 50 (1) ◽  
Author(s):  
Pradeep Kumar ◽  
Pravin Kumar ◽  
K. Zachariah ◽  
R. Vijayaraghavan ◽  
G.P. Rai ◽  
...  
Keyword(s):  
Immune System ◽  
Pulmonary Immune System

scholarly journals The Role of Innate Lymphoid Cells in Chronic Respiratory Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Amy T. Hsu ◽  
Timothy A. Gottschalk ◽  
Evelyn Tsantikos ◽  
Margaret L. Hibbs
Keyword(s):  
Immune System ◽  
Respiratory Diseases ◽  
Pulmonary Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Chronic Obstructive ◽  
Chronic Respiratory Diseases ◽  
Chronic Lung Diseases ◽  
Pulmonary Immune System

The lung is a vital mucosal organ that is constantly exposed to the external environment, and as such, its defenses are continuously under threat. The pulmonary immune system has evolved to sense and respond to these danger signals while remaining silent to innocuous aeroantigens. The origin of the defense system is the respiratory epithelium, which responds rapidly to insults by the production of an array of mediators that initiate protection by directly killing microbes, activating tissue-resident immune cells and recruiting leukocytes from the blood. At the steady-state, the lung comprises a large collection of leukocytes, amongst which are specialized cells of lymphoid origin known as innate lymphoid cells (ILCs). ILCs are divided into three major helper-like subsets, ILC1, ILC2 and ILC3, which are considered the innate counterparts of type 1, 2 and 17 T helper cells, respectively, in addition to natural killer cells and lymphoid tissue inducer cells. Although ILCs represent a small fraction of the pulmonary immune system, they play an important role in early responses to pathogens and facilitate the acquisition of adaptive immunity. However, it is now also emerging that these cells are active participants in the development of chronic lung diseases. In this mini-review, we provide an update on our current understanding of the role of ILCs and their regulation in the lung. We summarise how these cells and their mediators initiate, sustain and potentially control pulmonary inflammation, and their contribution to the respiratory diseases chronic obstructive pulmonary disease (COPD) and asthma.

scholarly journals Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine

2018 ◽  
Vol 10 (5-6) ◽  
pp. 487-501 ◽  
Author(s):  
Dominik Hartl ◽  
Rabindra Tirouvanziam ◽  
Julie Laval ◽  
Catherine M. Greene ◽  
David Habiel ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Respiratory Tract ◽  
Defense Mechanisms ◽  
Innate Immune ◽  
Particle Interactions ◽  
Complex Interplay ◽  
Pulmonary Immune System ◽  
Barrier Zone ◽  
Key Pathways

The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment. Here, we summarize and discuss recent findings on pulmonary innate immunity and highlight key pathways relevant for biomarker and therapeutic targeting strategies for acute and chronic diseases of the respiratory tract.

Ontogeny of the Pulmonary Immune System

The Lung ◽  
2014 ◽  
pp. 211-222
Author(s):  
Candace M. Crowley ◽  
Lisa A. Miller
Keyword(s):  
Immune System ◽  
Pulmonary Immune System

Immunopathologic effects of nickel subsulfide on the primate pulmonary immune system

1987 ◽  
Vol 88 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Patrick J. Haley ◽  
David E. Bice ◽  
Bruce A. Muggenburg ◽  
Fletcher F. Hann ◽  
Stephen A. Benjamin
Keyword(s):  
Immune System ◽  
Pulmonary Immune System ◽  
Nickel Subsulfide

scholarly journals Interaction of biomedical nanoparticles with the pulmonary immune system

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Fabian Blank ◽  
Kleanthis Fytianos ◽  
Emilie Seydoux ◽  
Laura Rodriguez-Lorenzo ◽  
Alke Petri-Fink ◽  
...  
Keyword(s):  
Immune System ◽  
Pulmonary Immune System
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