Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors

1994 ◽  
Vol 46 (4) ◽  
Author(s):  
R. Laaksonen ◽  
J.-P. Ojala ◽  
M.J. Tikkanen ◽  
J.-J. Himberg
Keyword(s):  
Term Treatment ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Long Term Treatment ◽  
Hmg Coa Reductase Inhibitors ◽  
Short And Long Term ◽  
Coa Reductase

Long-term safety and efficacy of combination gemfibrozil and HMG-CoA reductase inhibitors for the treatment of mixed lipid disorders

1999 ◽  
Vol 138 (1) ◽  
pp. 151-155 ◽  
Author(s):  
David K. Murdock ◽  
Anthony K. Murdock ◽  
Robert W. Murdock ◽  
Karen J. Olson ◽  
Arlyne M. Frane ◽  
...  
Keyword(s):  
Hmg Coa Reductase ◽  
Safety And Efficacy ◽  
Lipid Disorders ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

Therapy with HMG CoA reductase inhibitors: characteristics of the long-term permanence of hypocholesterolemic activity

1995 ◽  
Vol 117 (2) ◽  
pp. 189-198 ◽  
Author(s):  
F. Pazzucconi ◽  
F. Dorigotti ◽  
G. Gianfranceschi ◽  
G. Campagnoli ◽  
M. Sirtori ◽  
...  
Keyword(s):  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

Prevention of Hepatocellular Carcinoma by Statins: Clinical Evidence and Plausible Mechanisms

2019 ◽  
Vol 39 (02) ◽  
pp. 141-152 ◽  
Author(s):  
Gyuri Kim ◽  
Eun Seok Kang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mevalonate Pathway ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Term Treatment ◽  
Hmg Coa Reductase ◽  
Reductase Inhibitors ◽  
Novel Approach ◽  
Long Term Treatment ◽  
Coa Reductase

AbstractStatins, or 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are widely used to treat hypercholesterolemia for primary and secondary prevention of cardiovascular disease. Statins inhibit HMG-CoA reductase, the rate-limiting step in cholesterol synthesis, and modulate the downstream signaling of the mevalonate pathway. In addition to the primary effect, the antitumor effect of statins can be associated with mevalonate pathway-mediated and nonmevalonate pathway-mediated mechanisms, which improve endothelial function and lead to proapoptotic, antiproliferative, antiinflammatory, and antifibrotic properties. Statins are implicated in the improvement of metabolic status. Statins are orally available and safely and widely used for long-term treatment; they represent a novel approach for the prevention and treatment for hepatocellular carcinoma (HCC). Although several observational studies and experimental studies have revealed the preventive and therapeutic potential of statins for HCC treatment, further prospective interventional studies and randomized control trials are warranted to confirm these observations.

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