Pharmacological effects of concomitant administration of ?-adrenoceptor blocker and agonist in normal subjects: characterization by heart rate response to exercise

1995 ◽  
Vol 48 (6) ◽  
Author(s):  
M. Karita ◽  
H. Sato ◽  
Y. Koretsune ◽  
K. Imai ◽  
H. Ozaki ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Response ◽  
Concomitant Administration ◽  
Normal Subjects ◽  
Pharmacological Effects ◽  
Adrenoceptor Blocker ◽  
Response To Exercise

Heart Rate Response to Exercise

2018 ◽  
pp. 437-445
Author(s):  
Gregory S. Thomas
Keyword(s):  
Heart Rate ◽  
Physical Fitness ◽  
Sample Size ◽  
Older Persons ◽  
Heart Rate Response ◽  
Large Sample Size ◽  
Maximum Heart Rate ◽  
Large Sample ◽  
Response To Exercise

The chapter Heart Rate Response to Exercise reviews the studies performed to estimate a patient’s maximum predicted heart rate. While the commonly used formula (220 – age), developed in 1971, is easy to remember, it underestimates the actual maximum heart rate in older persons. Studies of large sample size have found the maximum heart rate to be relatively independent of sex and physical fitness but to incrementally decline with age. The decrease with age is less than 1 beat per minute per year, however. A more accurate and recommended formula is [(208) – (0.7)(age)] as developed by Tanaka and colleagues.

Comparison of phenylephrine bolus and infusion methods in baroreflex measurements

1990 ◽  
Vol 69 (3) ◽  
pp. 962-967 ◽  
Author(s):  
J. T. Sullebarger ◽  
C. S. Liang ◽  
P. D. Woolf ◽  
A. E. Willick ◽  
J. F. Richeson
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Baroreflex Sensitivity ◽  
Heart Rate Response ◽  
Pressor Response ◽  
Plasma Catecholamines ◽  
Systolic Arterial Pressure ◽  
Normal Subjects ◽  
Vagus Nerves ◽  
Baroreflex Control

Phenylephrine (PE) bolus and infusion methods have both been used to measure baroreflex sensitivity in humans. To determine whether the two methods produce the same values of baroreceptor sensitivity, we administered intravenous PE by both bolus injection and graded infusion methods to 17 normal subjects. Baroreflex sensitivity was determined from the slope of the linear relationship between the cardiac cycle length (R-R interval) and systolic arterial pressure. Both methods produced similar peak increases in arterial pressure and reproducible results of baroreflex sensitivity in the same subjects, but baroreflex slopes measured by the infusion method (9.9 +/- 0.7 ms/mmHg) were significantly lower than those measured by the bolus method (22.5 +/- 1.8 ms/mmHg, P less than 0.0001). Pretreatment with atropine abolished the heart rate response to PE given by both methods, whereas plasma catecholamines were affected by neither method of PE administration. Naloxone pretreatment exaggerated the pressor response to PE and increased plasma beta-endorphin response to PE infusion but had no effect on baroreflex sensitivity. Thus our results indicate that 1) activation of the baroreflex by the PE bolus and infusion methods, although reproducible, is not equivalent, 2) baroreflex-induced heart rate response to a gradual increase in pressure is less than that seen with a rapid rise, 3) in both methods, heart rate response is mediated by the vagus nerves, and 4) neither the sympathetic nervous system nor the endogenous opiate system has a significant role in mediating the baroreflex control of heart rate to a hypertensive stimulus in normal subjects.

THE HEART RATE RESPONSE TO EXERCISE IN HEALTHY WOMEN AGED 13 TO 88

1992 ◽  
Vol 85 (Supplement) ◽  
pp. 3S-45
Author(s):  
Allen F. Bowyer ◽  
Rosemary A. Thomas
Keyword(s):  
Heart Rate ◽  
Heart Rate Response ◽  
Healthy Women ◽  
Response To Exercise

Heart rate control in diabetic rabbits: blunted response to isoproterenol

1988 ◽  
Vol 255 (5) ◽  
pp. E636-E641 ◽  
Author(s):  
B. E. Zola ◽  
B. Miller ◽  
G. L. Stiles ◽  
P. S. Rao ◽  
E. H. Sonnenblick ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Response ◽  
Atropine Sulfate ◽  
Left Ventricular ◽  
Heart Weight ◽  
Base Line ◽  
Baroreceptor Reflexes ◽  
Diabetic Rabbits ◽  
Alloxan Monohydrate ◽  
Response To Exercise

To study the effects of chronic diabetes on heart rate and adrenergic responsiveness we compared unanesthetized diabetic rabbits, 10-13 mo after alloxan monohydrate injection, to age-matched controls. There were no significant differences found between groups for body or heart weight. Both resting and intrinsic heart rate (the latter obtained after atropine sulfate and propranolol HCl) were similar. In addition, serum and left ventricular epinephrine and norepinephrine concentrations as well as left ventricular beta-receptor density and affinity were unchanged in diabetic animals. Heart rate responses to isoproterenol were blunted in diabetics at the three highest doses. Base-line mean blood pressure was modestly lower in diabetic rabbits, and parallel declines in pressure for both groups were observed in response to isoproterenol. The diminished heart rate response to isoproterenol in diabetic rabbits may be due to diminished myocardial sensitivity to catecholamines, possibly combined with altered baroreceptor reflexes. These experiments may provide an explanation for the blunted heart rate response to exercise described in human diabetics.

Abnormal heart rate response to exercise in vasospastic angina: Pathophysiologic mechanism in the provocation of coronary spasm

1984 ◽  
Vol 108 (2) ◽  
pp. 316-326 ◽  
Author(s):  
Iwao Sato ◽  
Katsuro Shimomura ◽  
Yasuhiro Hasegawa ◽  
Tohru Ohe ◽  
Mokuo Matsuhisa ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Response ◽  
Coronary Spasm ◽  
Vasospastic Angina ◽  
Pathophysiologic Mechanism ◽  
Response To Exercise

Effect of lung transplantation on heart rate response to exercise

Heart & Lung ◽  
2015 ◽  
Vol 44 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Hilary F. Armstrong ◽  
Jose Gonzalez-Costello ◽  
Wilawan Thirapatarapong ◽  
Ulrich P. Jorde ◽  
Matthew N. Bartels
Keyword(s):  
Heart Rate ◽  
Lung Transplantation ◽  
Heart Rate Response ◽  
Response To Exercise

System analysis of heart rate control in man

1976 ◽  
Vol 41 (5) ◽  
pp. 790-796 ◽  
Author(s):  
I. Sato ◽  
Y. Hasegawa ◽  
K. Hotta
Keyword(s):  
Heart Rate ◽  
Weight Function ◽  
Rate Control ◽  
Cross Correlation ◽  
System Analysis ◽  
Heart Rate Response ◽  
Control Function ◽  
Heart Rate Control ◽  
Young Males ◽  
Response To Exercise

The dynamic property of the heart rate response to exercise was determined and expressed in the frequency domain to establish a method of examiningcardiovascular control function. The response of heart rate to a stimulus was measured at 5-s intervals in nine healthy young volunteers. The stimulusconsisted of several runs of two-step exercise practiced in semirandom sequence for 19 min. The weight function of the system was estimated from autocorrelation function of the input signal and cross-correlation function between the input and output signals. The weight function was transformed into a transfer function and its Bode plot diagram was drawn. From the diagram, four dynamic parameters were determined. These parameters are as follows: Kis a constant showing the theoretical steady-state increment of heart rate,and T1, T2, T3 are time constants. The values obtained in the present experiment with the healthy young males were: K 46.0 +/- 14.6 beats, T1, 2.12 +/- 0.44, T2, 1.12 +/- 0.16, and T3 0.70 +/- 0.07 min.

scholarly journals Mechanism of the attenuated peak heart rate response to exercise after orthotopic cardiac transplantation

1989 ◽  
Vol 14 (2) ◽  
pp. 338-344 ◽  
Author(s):  
Rebecca J. Quigg ◽  
Michael B. Rocco ◽  
Diane F. Gauthier ◽  
Mark A. Creager ◽  
L. Howard Hartley ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cardiac Transplantation ◽  
Heart Rate Response ◽  
Peak Heart Rate ◽  
Response To Exercise

scholarly journals Reduced heart rate response to exercise in ischemic heart disease

1979 ◽  
Vol 11 (3) ◽  
pp. 227???233
Author(s):  
A. C.P. POWLES ◽  
J. R. SUTTON ◽  
J. R. WICKS ◽  
N. B. OLDRIDGE ◽  
N. L. JONES
Keyword(s):  
Heart Rate ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Heart Rate Response ◽  
Ischemic Heart ◽  
Response To Exercise
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