Alleles of the rat T-cell receptor ? chain gene complex

1992 ◽  
Vol 35 (5) ◽  
Author(s):  
ElizabethP. Blankenhorn ◽  
PaulD. Smith ◽  
CalvinB. Williams ◽  
GeorgeA. Gutman
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Gene Complex ◽  
Receptor Chain

scholarly journals The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.

1987 ◽  
Vol 165 (5) ◽  
pp. 1237-1251 ◽  
Author(s):  
B L Kotzin ◽  
E Palmer
Keyword(s):  
T Cell ◽  
Renal Disease ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Gene Complex ◽  
Beta Chain ◽  
Autoantibody Production ◽  
Severe Renal Disease ◽  
Cell Receptor Alpha

Unlike parental NZB or NZW mice, (NZB X NZW)F1 mice exhibit a lupus-like disease characterized by high serum levels of IgG antinuclear antibodies and a fatal immune-complex glomerulonephritis. At least three unlinked gene loci can be distinguished in NZW mice that conceivably contribute to a T cell-dependent autoimmune disease, including the MHC (H-2z) and the T cell receptor alpha and beta chain gene complexes. We undertook an (NZB X NZW)F1 X NZB backcross to determine the relative contribution of these NZW genes to lupus-like renal disease and autoantibody production in F1 mice. The incidence of severe renal disease and elevated levels of IgG antibodies to dsDNA and histone in the backcross mice was approximately half of that observed in (NZB X NZW)F1 mice. Furthermore, there was a strong correlation between the presence of the NZW H-2z haplotype and lupus-like disease in backcross mice. Approximately 90% of backcross mice with disease carried the NZW H-2z locus compared with 16% of mice without disease; nearly 90% of H-2d/z mice expressed severe autoimmune disease. In contrast, no association was apparent between the presence of the NZW T cell receptor alpha chain gene complex or beta chain gene complex and severe renal disease or autoantibody production. Thus, the NZW MHC or gene(s) linked to this locus appear to be the only dominant NZW genetic contribution to F1 disease.

A Simplified Method of Detection of Clonal Rearrangements of the T-Cell Receptor-?? Chain Gene

1992 ◽  
Vol 1 (1) ◽  
pp. 173-179 ◽  
Author(s):  
Keith P. McCarthy ◽  
John P. Sloane ◽  
Janusz H.S. Kabarowski ◽  
Estela Matutes ◽  
Leanne M. Wiedemann
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Simplified Method ◽  
Receptor Chain

Contribution of the gene linked to the T cell receptor β chain gene complex of NZW mice to the autoimmunity of (NZB × NZW)F1 mice

1991 ◽  
Vol 21 (3) ◽  
pp. 823-826 ◽  
Author(s):  
Sachiko Hirose ◽  
Katsutoshi Tokushige ◽  
Kohji Kinoshita ◽  
Shingo Nozawa ◽  
Juichi Saito ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Gene Complex ◽  
Β Chain

scholarly journals Effect of gene linked to T cell receptor α chain gene complex of NZW mice on autoimmunity in NZB×NZW F1 mice

1992 ◽  
Vol 38 (2) ◽  
pp. 229-238
Author(s):  
SHINGO NOZAWA ◽  
KATSUTOSHI TOKUSHIGE ◽  
HIROYUKI NISHIMURA ◽  
SACHIKO HIROSE
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Gene Complex ◽  
Α Chain
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