Sequence and diversity of variable gene segments coding for rabbit T-cell receptor beta chains

1994 ◽  
Vol 39 (4) ◽  
Author(s):  
Takahiro Isono ◽  
Yuji Isegawa ◽  
Akira Seto
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Receptor Beta

Evaluating the link between T cell receptor beta variable gene polymorphism and immune mediated adverse events during checkpoint blockade immunotherapy.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e15002-e15002 ◽  
Author(s):  
Timothy Looney ◽  
Elizabeth Linch ◽  
Geoffrey Lowman ◽  
Lauren Miller ◽  
Jianping Zheng ◽  
...  
Keyword(s):  
T Cell ◽  
Adverse Events ◽  
Gene Polymorphism ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Immune Mediated ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Receptor Beta

scholarly journals Effect of Triptolide on T-Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen-Induced Arthritis

2012 ◽  
Vol 295 (6) ◽  
pp. 922-927 ◽  
Author(s):  
Jixi Wang ◽  
Aibing Wang ◽  
Heqing Zeng ◽  
Lantao Liu ◽  
Wenhao Jiang ◽  
...  
Keyword(s):  
T Cell ◽  
Mrna Expression ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Collagen Induced Arthritis ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Receptor Beta ◽  
Gene Mrna

scholarly journals The T Cell Receptor (TRB) Locus in Tursiops truncatus: From Sequence to Structure of the Alpha/Beta Heterodimer in the Human/Dolphin Comparison

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 571
Author(s):  
Giovanna Linguiti ◽  
Sofia Kossida ◽  
Ciro Leonardo Pierri ◽  
Joumana Jabado-Michaloud ◽  
Geraldine Folch ◽  
...  
Keyword(s):  
Amino Acids ◽  
T Cell ◽  
T Cell Receptor ◽  
Tursiops Truncatus ◽  
Cell Receptor ◽  
Sequence Alignments ◽  
T Cell Receptor Beta ◽  
Alpha Beta ◽  
Receptor Beta ◽  
Complementarity Determining Region

The bottlenose dolphin (Tursiops truncatus) belongs to the Cetartiodactyla and, similarly to other cetaceans, represents the most successful mammalian colonization of the aquatic environment. Here we report a genomic, evolutionary, and expression study of T. truncatus T cell receptor beta (TRB) genes. Although the organization of the dolphin TRB locus is similar to that of the other artiodactyl species, with three in tandem D-J-C clusters located at its 3′ end, its uniqueness is given by the reduction of the total length due essentially to the absence of duplications and to the deletions that have drastically reduced the number of the germline TRBV genes. We have analyzed the relevant mature transcripts from two subjects. The simultaneous availability of rearranged T cell receptor α (TRA) and TRB cDNA from the peripheral blood of one of the two specimens, and the human/dolphin amino acids multi-sequence alignments, allowed us to calculate the most likely interactions at the protein interface between the alpha/beta heterodimer in complex with major histocompatibility class I (MH1) protein. Interacting amino acids located in the complementarity-determining region according to IMGT numbering (CDR-IMGT) of the dolphin variable V-alpha and beta domains were identified. According to comparative modelization, the atom pair contact sites analysis between the human MH1 grove (G) domains and the T cell receptor (TR) V domains confirms conservation of the structure of the dolphin TR/pMH.

Germ-line configuration of the T-cell receptor beta-chain gene in B-cell chronic lymphoproliferative disorders which co-express T-cell antigens

2009 ◽  
Vol 39 (5) ◽  
pp. 412-417 ◽  
Author(s):  
Fortunato Morabito ◽  
Angela Tassinari ◽  
Vincenzo Callea ◽  
Maura Brugiatelli ◽  
Maria Teresa Fierro ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Germ Line ◽  
Cell Receptor ◽  
Lymphoproliferative Disorders ◽  
Chain Gene ◽  
Line Configuration ◽  
T Cell Antigens ◽  
T Cell Receptor Beta ◽  
Receptor Beta
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