Regional differences in the distribution of nerve fibers showing substance P- and calcitonin gene-related peptide-like immunoreactivity in the rat larynx

1991 ◽  
Vol 183 (1) ◽  
Author(s):  
S. Domeij ◽  
�. Dahlqvist ◽  
S. Forsgren
Keyword(s):  
Substance P ◽  
Regional Differences ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Fibers ◽  
Related Peptide ◽  
Calcitonin Gene

Distribution of substance P and calcitonin gene-related peptide immunoreactive nerve fibers in the trachea of chronically hypoxic rats

1996 ◽  
Vol 39 (6) ◽  
pp. 335-339 ◽  
Author(s):  
T. Kusakabe ◽  
T. Kawakami ◽  
F.L. Powell ◽  
M.H. Ellisman ◽  
H. Sawada ◽  
...  
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Fibers ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes

2021 ◽  
Vol 12 ◽  
Author(s):  
Sabine Stöckl ◽  
Annett Eitner ◽  
Richard J. Bauer ◽  
Matthias König ◽  
Brian Johnstone ◽  
...  
Keyword(s):  
Substance P ◽  
Structural Damage ◽  
Articular Chondrocytes ◽  
Sensory Nerve ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Fibers ◽  
Joint Disease ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Oa Chondrocytes

Osteoarthritis (OA) is a degenerative joint disease that not only causes cartilage loss but also structural damage in all joint tissues. Joints are innervated by alpha-calcitonin gene-related peptide (αCGRP) and substance P (SP)-positive sensory nerve fibers. Alteration of sensory joint innervation could be partly responsible for degenerative changes in joints that contribute to the development of OA. Therefore, our aim was to analyze and compare the molecular effects of SP and αCGRP on the metabolism of articular chondrocytes from OA patients and non-OA cartilage donors. We treated the cells with SP or αCGRP and analysed the influence of these neuropeptides on chondrocyte metabolism and modulation of signaling pathways. In chondrocytes from healthy cartilage, SP had minimal effects compared with its effects on OA chondrocytes, where it induced inflammatory mediators, inhibited chondrogenic markers and promoted apoptosis and senescence. Treatment with αCGRP also increased apoptosis and senescence and reduced chondrogenic marker expression in OA chondrocytes, but stimulated an anabolic and protective response in healthy chondrocytes. The catabolic influence of SP and αCGRP might be due to activation of ERK signaling that could be counteracted by an increased cAMP response. We suggest that a switch between the G-subunits of the corresponding receptors after binding their ligands SP or αCGRP plays a central role in mediating the observed effects of sensory neuropeptides on chondrocytes.

Similar Distribution of Mast Cells and Substance P- and Calcitonin Gene-Related Peptide-Immunoreactive Nerve Fibers in the Adult Human Larynx

1996 ◽  
Vol 105 (10) ◽  
pp. 825-831 ◽  
Author(s):  
Siw Domeu ◽  
Anders Eriksson ◽  
Åke Dahlqvist ◽  
Store Forsgren
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Fibers ◽  
The Body ◽  
Similar Distribution ◽  
Related Peptide ◽  
Adult Human ◽  
Calcitonin Gene ◽  
Human Larynx

The mechanisms causing supraglottic and subglottic edema in the human larynx are not fully understood. Substance P (SP)- and calcitonin gene-related peptide (CGRP)-containing nerve fibers and mast cells have been suggested to induce inflammation and edema in other parts of the body. In this study of the adult human larynx the distribution of mast cells was studied in relation to SP- and CGRP-containing nerve fibers. Substance P- and CGRP-immunoreactive nerve fibers and numerous mast cells were found in the epiglottis and in the subglottic region of the larynx. Only occasional mast cells and no nerve fibers showing SP- or CGRP-like irnmunoreactivity were found in the vocal cords. In conclusion, the present study has shown that the distribution of nerve fibers showing SP- and CGRP-like irnmunoreactivity and mast cells has a similar regional variability. As the highest density of SP- and CGRP-containing nerve fibers and mast cells was present in the regions of the larynx where edema occurs, SP, CGRP, and/or mast cells might be involved in the pathogenesis of edema.

Sign in / Sign up

Export Citation Format

Share Document