Androgen-receptor gene structure and function in prostate cancer

1996 ◽  
Vol 14 (5) ◽  
Author(s):  
J.M. Hakimi ◽  
R.H. Rondinelli ◽  
M.P. Schoenberg ◽  
E.R. Barrack
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Gene Structure ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Structure And Function ◽  
And Function

Expression and somatic mutation on androgen receptor gene in prostate cancer

2002 ◽  
Vol 9 (10) ◽  
pp. 545-553 ◽  
Author(s):  
NAOKI SEGAWA ◽  
MISA NAKAMURA ◽  
LIANG SHAN ◽  
HIROTOSHI UTSUNOMIYA ◽  
YASUSHI NAKAMURA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Somatic Mutation ◽  
Receptor Gene ◽  
Androgen Receptor Gene

scholarly journals Cag Repeat Number in the Androgen Receptor Gene and Prostate Cancer

2012 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
S Madjunkova ◽  
A Eftimov ◽  
V Georgiev ◽  
D Petrovski ◽  
A Dimovski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Repeat Number

Cag Repeat Number in the Androgen Receptor Gene and Prostate CancerProstate cancer (PC) is the second leading cause of cancer deaths in men. The effects of androgens on prostatic tissue are mediated by the androgen receptor (AR) gene. The 5' end of exon 1 of the AR gene includes a polymorphic CAG triplet repeat that numbers between 10 to 36 in the normal population. The length of the CAG repeats is inversely related to the transactivation function of the AR gene. There is controversy over association between short CAG repeat numbers in the AR gene and PC. This retrospective case-control study evaluates the possible effect of short CAG repeats on the AR gene in prostate cancer risk in Macedonian males. A total of 392 male subjects, 134 PC patients, 106 patients with benign prostatic hyperplasia (BPH) and 152 males from the general Macedonian population were enrolled in this study. The CAG repeat length was determined by fluorescent polymerase chain reaction (PCR) amplification of exon1 of the AR gene followed by capillary electrophoresis (CE) on a genetic analyzer. The mean repeat length in PC patients was 21.5 ±2.65, in controls 22.28 ±2.86 (p = 0.009) and in BPH patients 22.1 ±2.52 (p = 0.038). Short CAG repeats (<19) were found in 21.64% of PC patients vs. 9.43% in BPH patients (p = 0.0154). We also found an association of low Gleason score (<7) with short CAG repeat (<19) in PC patients (p = 0.0306), and no association between the age at diagnosis of PC and BPH and CAG repeat length. These results suggest that reduced CAG repeat length may be associated with increased prostate cancer risk in Macedonian men.

scholarly journals Androgen receptor gene mutations in human prostate cancer.

1992 ◽  
Vol 89 (14) ◽  
pp. 6319-6323 ◽  
Author(s):  
J. R. Newmark ◽  
D. O. Hardy ◽  
D. C. Tonb ◽  
B. S. Carter ◽  
J. I. Epstein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Gene Mutations ◽  
Androgen Receptor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

Androgen Receptor Gene Copy Number and Protein Expression in Treatment-Naïve Prostate Cancer

2017 ◽  
Vol 99 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Filip Poelaert ◽  
Candy Kumps ◽  
Nicolaas Lumen ◽  
Stephanie Verschuere ◽  
Louis Libbrecht ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Protein Expression ◽  
Copy Number ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Androgen Receptor Gene ◽  
Gene Copy ◽  
Treatment Naïve
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