Effects of fixed-ratio length on the development of tolerance to decreased responding by l-nantradol

1986 ◽  
Vol 90 (2) ◽  
Author(s):  
JamesB. Smith
Keyword(s):  
Fixed Ratio ◽  
Development Of Tolerance

scholarly journals The development of tolerance to morphine under discrete-trial fixed-ratio, automaintenance, and negative automaintenance procedures

1982 ◽  
Vol 19 (4) ◽  
pp. 249-252 ◽  
Author(s):  
Mitchell Picker ◽  
Deborah Grossett ◽  
Robert Sewell ◽  
Brian Zimmermann ◽  
Alan Poling
Keyword(s):  
Fixed Ratio ◽  
Discrete Trial ◽  
Negative Automaintenance ◽  
Development Of Tolerance

Drug-Behavior Interaction Affecting Development of Tolerance to D-Amphetamine as Observed in Fixed Ratio Behavior of Rats

1965 ◽  
Vol 16 (3) ◽  
pp. 917-921 ◽  
Author(s):  
Hugh Brown
Keyword(s):  
Fixed Ratio ◽  
Experimental Chamber ◽  
Depressing Effect ◽  
Development Of Tolerance ◽  
Behavior Of Rats

Two groups of three rats each were trained to perform on a food-reinforced FR50 schedule. One group, subjected to daily dosage with 3.0 mg/kg d-amphetamine, developed tolerance to the depressing effect of the drug within 10 days. A second group similarly treated, except that the animals were not placed in the experimental chamber during daily dosage until the tenth day, failed to develop tolerance for 20 consecutive subsequent drug administrations. The finding is interpreted as a drug-behavior interaction.

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