Maturation of binaural interaction components in auditory brainstem responses of young guinea pigs with monaural or binaural conductive hearing loss

1992 ◽  
Vol 249 (6) ◽  
pp. 325-328 ◽  
Author(s):  
M. Laska ◽  
M. Walger ◽  
I. Schneider ◽  
H. von Wedel
Keyword(s):  
Hearing Loss ◽  
Guinea Pigs ◽  
Conductive Hearing Loss ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Binaural Interaction ◽  
Conductive Hearing

Auditory Brainstem Responses in a Case of High-Frequency Conductive Hearing Loss

1985 ◽  
Vol 50 (4) ◽  
pp. 346-350 ◽  
Author(s):  
Michael P. Gorga ◽  
Jan K. Reiland ◽  
Kathryn A. Beauchaine
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Conductive Hearing Loss ◽  
Auditory Brainstem ◽  
Intensity Function ◽  
Auditory Brainstem Responses ◽  
Normal Limits ◽  
Interpeak Latency ◽  
Lower Limits ◽  
Conductive Hearing

Click-evoked auditory brainstem responses were measured in a patient with high-frequency conductive hearing loss. As is typical in cases of conductive hearing loss, Wave I latency was prolonged beyond normal limits. Interpeak latency differences were just below the lower limits of the normal range. The Wave V latency-intensity function, however was abnormally steep. This pattern is explained by the hypothesis that the slope of the latency-intensity function is determined principally by the configuration of the hearing loss. In cases of high-frequency hearing loss (regardless of the etiology), the response may be dominated by more apical regions of the cochlea at lower intensities and thus have a longer latency.

scholarly journals Air and Bone Conduction Frequency-specific Auditory Brainstem Response in Children with Agenesis of the External Auditory Canal

2017 ◽  
Vol 21 (04) ◽  
pp. 318-322 ◽  
Author(s):  
Pricila Sleifer ◽  
Dayane Didoné ◽  
Ísis Keppeler ◽  
Claudine Bueno ◽  
Rudimar Riesgo
Keyword(s):  
Hearing Loss ◽  
External Auditory Canal ◽  
Conductive Hearing Loss ◽  
Bone Conduction ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Significant Difference ◽  
Brainstem Response ◽  
Conductive Hearing ◽  
Air Conduction

Introduction The tone-evoked auditory brainstem responses (tone-ABR) enable the differential diagnosis in the evaluation of children until 12 months of age, including those with external and/or middle ear malformations. The use of auditory stimuli with frequency specificity by air and bone conduction allows characterization of hearing profile. Objective The objective of our study was to compare the results obtained in tone-ABR by air and bone conduction in children until 12 months, with agenesis of the external auditory canal. Method The study was cross-sectional, observational, individual, and contemporary. We conducted the research with tone-ABR by air and bone conduction in the frequencies of 500 Hz and 2000 Hz in 32 children, 23 boys, from one to 12 months old, with agenesis of the external auditory canal. Results The tone-ABR thresholds were significantly elevated for air conduction in the frequencies of 500 Hz and 2000 Hz, while the thresholds of bone conduction had normal values in both ears. We found no statistically significant difference between genders and ears for most of the comparisons. Conclusion The thresholds obtained by bone conduction did not alter the thresholds in children with conductive hearing loss. However, the conductive hearing loss alter all thresholds by air conduction. The tone-ABR by bone conduction is an important tool for assessing cochlear integrity in children with agenesis of the external auditory canal under 12 months.

Auditory Brainstem Responses in Children with Otitis Media with Effusion

1980 ◽  
Vol 89 (3_suppl) ◽  
pp. 200-206 ◽  
Author(s):  
Thomas J. Fria ◽  
Diane L. Sabo
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Pure Tone ◽  
Conductive Hearing Loss ◽  
Otitis Media With Effusion ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
School Age Children ◽  
School Age ◽  
Conductive Hearing

Auditory brainstem responses (ABR) were recorded in 14 infants and toddlers and 12 school-age children with a previous history of recurrent otitis media with effusion (OME), or otoscopic and tympanometric evidence of persistent OME, or both. ABR tests were performed immediately before and after myringotomy and tympanostomy tube insertion in the younger subjects. For the school-age children, ABR tests were performed following otoscopy, tympanometry, and pure tone audiometry. The results demonstrate that the latency of both wave I and wave V of the ABR was sensitive (82% and 100%, respectively) to the presence of OME. Wave I also identified the absence of OME (specificity = 100%) whereas wave V did not (specificity = 25%). ABR latency was significantly decreased postoperatively in ears found to have OME, but not in ears found to have no OME. In the school-age subjects the ABR was used to predict the conductive hearing loss at 4000 Hz with less than a 20 dB error in virtually all subjects. The ABR latency delay was also found to be related to conductive hearing impairment at lower pure tone frequencies and to the average conductive loss at a variety of pure tone frequencies. Predictions of the presence of a conductive hearing loss from these relationships promise to be impressively accurate. The results suggest that the ABR can be a valuable tool for detecting the presence of conductive hearing impairment in infants and young children suspected to have OME and perhaps as an estimate of the degree of impairment.

Conductive Hearing Loss During Infancy

1991 ◽  
Vol 34 (5) ◽  
pp. 1207-1215 ◽  
Author(s):  
Adele D. Gunnarson ◽  
Terese Finitzo
Keyword(s):  
Hearing Loss ◽  
Brain Stem ◽  
Conductive Hearing Loss ◽  
Long Term Effects ◽  
Binaural Interaction ◽  
Auditory Brain Stem ◽  
Significant Difference ◽  
Group B ◽  
Conductive Hearing ◽  
Fluctuating Hearing Loss

Long-term effects on auditory electrophysiology from early fluctuating hearing loss were studied in 27 children, aged 5 to 7 years, who had been evaluated originally in infancy. For controls (Group A), infant auditory brain stem responses (ABRs) were normal from birth to age 2 years. A second group (Group B) had intermittent conductive hearing loss. A third group (Group C) had more abnormal ABRs during infancy than Group B and more severe and frequent conductive hearing loss. For this follow-up study, all children had normal peripheral hearing at test. ABRs were obtained to monaural and binaural stimuli. Binaural interaction (BI) in the ABR was assessed in difference traces, derived by subtracting summed binaural from summed monaural waveforms.Controls differed from both groups with early hearing loss for wave III and wave V latencies and interpeak I–III and I–V latencies. There was a significant difference in the presence of BI. Eight of 9 A subjects and 8 of 9 B subjects, but only 4 of 9 C subjects, had demonstrable BI. Findings suggest that early fluctuating hearing loss disrupts later auditory brain stem electrophysiology.

Is the Conductive Hearing Loss in NOG-Related Symphalangism Spectrum Disorder Congenital?

ORL ◽  
2021 ◽  
pp. 1-7
Author(s):  
Takahiro Nakashima ◽  
Akira Ganaha ◽  
Shougo Tsumagari ◽  
Takeshi Nakamura ◽  
Yuusuke Yamada ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Family History ◽  
Conductive Hearing Loss ◽  
Hearing Threshold ◽  
Auditory Brainstem ◽  
Spectrum Disorder ◽  
Hearing Level ◽  
Success Rates ◽  
Brainstem Response ◽  
Conductive Hearing

We describe a dominant Japanese patient with progressive conductive hearing loss who was diagnosed with <i>NOG</i>-related symphalangism spectrum disorder (<i>NOG</i>-SSD), a spectrum of congenital stapes fixation syndromes caused by <i>NOG</i> mutations. Based on the clinical features, including proximal symphalangism, conductive hearing loss, hyper­opia, and short, broad middle, and distal phalanges of the thumbs, his family was diagnosed with stapes ankylosis with broad thumbs and toes syndrome (SABTT). Genetic analysis revealed a heterozygous substitution in the <i>NOG</i> gene, c.645C&#x3e;A, p.C215* in affected family individuals. He had normal hearing on auditory brainstem response (ABR) testing at ages 9 months and 1 and 2 years. He was followed up to evaluate the hearing level because of his family history of hearing loss caused by SABTT. Follow-up pure tone average testing revealed the development of progressive conductive hearing loss. Stapes surgery was performed, and his post-operative hearing threshold improved to normal in both ears. According to hearing test results, the stapes ankylosis in our SABTT patient seemed to be incomplete at birth and progressive in early childhood. The ABR results in our patient indicated the possibility that newborn hearing screening may not detect conductive hearing loss in patients with <i>NOG</i>-SSD. Hence, children with a family history and/or known congenital joint abnormality should undergo periodic hearing tests due to possible progressive hearing loss. Because of high success rates of stapes surgeries in cases of SABTT, early surgical interventions would help minimise the negative effect of hearing loss during school age. Identification of the nature of conductive hearing loss due to progressive stapes ankylosis allows for better genetic counselling and proper intervention in <i>NOG</i>-SSD patients.

scholarly journals Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex

2021 ◽  
Vol 15 ◽  
Author(s):  
Jing Liu ◽  
Xinyi Huang ◽  
Jiping Zhang
Keyword(s):  
Hearing Loss ◽  
Auditory Cortex ◽  
Conductive Hearing Loss ◽  
Spatial Perception ◽  
Primary Auditory Cortex ◽  
Binaural Hearing ◽  
Adult Rats ◽  
Binaural Processing ◽  
Binaural Interaction ◽  
Conductive Hearing

Binaural hearing is critically important for the perception of sound spatial locations. The primary auditory cortex (AI) has been demonstrated to be necessary for sound localization. However, after hearing onset, how the processing of binaural cues by AI neurons develops, and how the binaural processing of AI neurons is affected by reversible unilateral conductive hearing loss (RUCHL), are not fully elucidated. Here, we determined the binaural processing of AI neurons in four groups of rats: postnatal day (P) 14–18 rats, P19–30 rats, P57–70 adult rats, and RUCHL rats (P57–70) with RUCHL during P14–30. We recorded the responses of AI neurons to both monaural and binaural stimuli with variations in interaural level differences (ILDs) and average binaural levels. We found that the monaural response types, the binaural interaction types, and the distributions of the best ILDs of AI neurons in P14–18 rats are already adult-like. However, after hearing onset, there exist developmental refinements in the binaural processing of AI neurons, which are exhibited by the increase in the degree of binaural interaction, and the increase in the sensitivity and selectivity to ILDs. RUCHL during early hearing development affects monaural response types, decreases the degree of binaural interactions, and decreases both the selectivity and sensitivity to ILDs of AI neurons in adulthood. These new evidences help us to understand the refinements and plasticity in the binaural processing of AI neurons during hearing development, and might enhance our understanding in the neuronal mechanism of developmental changes in auditory spatial perception.

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