Loss of heterozygosity of microsatellite loci on chromosome 9p in astrocytic tumors and its prognostic implications

1996 ◽  
Vol 30 (1) ◽  
Author(s):  
Motohiko Maruno ◽  
Toshiki Yoshimine ◽  
A.K.M. Ghulam Muhammad ◽  
Koji Tokiyoshi ◽  
Toru Hayakawa
Keyword(s):  
Loss Of Heterozygosity ◽  
Microsatellite Loci ◽  
Astrocytic Tumors ◽  
Prognostic Implications ◽  
Chromosome 9P

An astroblastoma case associated with loss of heterozygosity on chromosome 9p

2006 ◽  
Vol 80 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Nobuhiro Hata ◽  
Tadahisa Shono ◽  
Koji Yoshimoto ◽  
Masahiro Mizoguchi ◽  
Tadao Kawamura ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Chromosome 9P

Analysis of loss of heterozygosity for chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival

2001 ◽  
Vol 95 (4) ◽  
pp. 651-659 ◽  
Author(s):  
Kenji Tada ◽  
Shoji Shiraishi ◽  
Takanori Kamiryo ◽  
Hideo Nakamura ◽  
Hirofumi Hirano ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Loss Of Heterozygosity ◽  
Low Grade ◽  
Astrocytic Tumors ◽  
Chromosome 10 ◽  
Patient Age ◽  
Content Type ◽  
Unfavorable Prognostic Factor ◽  
Patient Âgé ◽  
Fine Print

Object. The most frequent genetic abnormality in human malignant gliomas is loss of heterozygosity (LOH) on chromosome 10. Candidate genes on chromosome 10 that are associated with the prognosis of patients with anaplastic astrocytoma (AA) and glioblastoma (GBM) were evaluated. Methods. The authors used 12 fluorescent microsatellite markers on both arms of chromosome 10 to study LOH in 108 primary astrocytic tumors. The LOH on chromosome 10 was observed in 11 (32%) of 34 AAs and 34 (56%) of 61 GBMs. No LOH was detected in 13 low-grade gliomas. Loss of heterozygosity was not detected in any AA in the seven patients younger than 35 years, but it was discovered in 41% of the patients older than 35 years. The prognostic significance of LOH at each locus was evaluated in 89 patients older than 15 years; 33 (37%) had supratentorial AAs and 56 (63%) had supratentorial GBMs. The Cox proportional hazards model, adjusted for patient age at surgery, the preoperative Karnofsky Performance Scale score, and the extent of surgical resection revealed that LOH on marker D10S209 near the FGFR2 and DMBT1 genes was significantly associated with shorter survival in patients with AA. The LOH on markers D10S215 and D10S541, which contain the PTEN/MMAC1 gene between them, was significantly associated with shorter survival in patients with GBM. Conclusions. In the present study it is found that LOH on chromosome 10 is an age-dependent event for patients with AAs and that LOH on marker D10S209 near the FGFR2 and DMBT1 loci is a significantly unfavorable prognostic factor. It is also reported that LOH on the PTEN/MMAC1 gene is a significantly unfavorable prognostic factor in patients with GBM.

Prognostic implications of loss of heterozygosity in the 17q21 region in breast cancer

1997 ◽  
Author(s):  
B Gomendio ◽  
J Silva ◽  
M Provencio ◽  
J Garcia ◽  
E GarciaPatino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Loss Of Heterozygosity ◽  
Prognostic Implications ◽  
17Q21 Region

scholarly journals Chromosome 22q Allelic Losses at Microsatellite Loci in Human Astrocytic Tumors

1997 ◽  
Vol 37 (8) ◽  
pp. 606-611 ◽  
Author(s):  
A. K. M. Ghulam MUHAMMAD ◽  
Toshiki YOSHIMINE ◽  
Motohiko MARUNO ◽  
Koji TOKIYOSHI ◽  
Osamu TAKEMOTO ◽  
...  
Keyword(s):  
Microsatellite Loci ◽  
Astrocytic Tumors ◽  
Chromosome 22Q

Prognostic Implications of p53 Overexpression in Supratentorial Astrocytic Tumors

Neurosurgery ◽  
1994 ◽  
Vol 35 (5) ◽  
pp. 831-838 ◽  
Author(s):  
Bruce S. Chozick ◽  
John C. Pezzullo ◽  
Mel H. Epstein ◽  
Paul W. Finch
Keyword(s):  
Astrocytic Tumors ◽  
P53 Overexpression ◽  
Prognostic Implications
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