Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines

1990 ◽  
Vol 8 (2) ◽  
Author(s):  
JustinD. Cohen ◽  
H.Ian Robins
Keyword(s):  
Cell Lines ◽  
Rodent Cell

COMPARATIVE STUDIES OF PC12 AND MOUSE PHEOCHROMOCYTOMA–DERIVED RODENT CELL LINES AS MODELS FOR THE STUDY OF NEUROENDOCRINE SYSTEMS

2005 ◽  
Vol 41 (7) ◽  
pp. 197 ◽  
Author(s):  
DARCELLE N. DIXON ◽  
RHONDA A. LOXLEY ◽  
ANNA BARRON ◽  
SUSANNAH CLEARY ◽  
JACQUELINE K. PHILLIPS
Keyword(s):  
Cell Lines ◽  
Comparative Studies ◽  
Rodent Cell ◽  
Neuroendocrine Systems

scholarly journals Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Belinda M. Kumpel ◽  
Radka Saldova ◽  
Carolien A. M. Koeleman ◽  
Jodie L. Abrahams ◽  
Agnes Hipgrave Ederveen ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Lines ◽  
Clinical Efficacy ◽  
Rodent Cell

The establishment of rodent cell lines persistently producing HIV-1

Virology ◽  
1992 ◽  
Vol 186 (1) ◽  
pp. 167-174 ◽  
Author(s):  
Yaffa Mizrachi ◽  
Lars Sternas ◽  
David I. Volsky
Keyword(s):  
Cell Lines ◽  
Rodent Cell ◽  
Hiv 1

scholarly journals Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines

2016 ◽  
Vol 428 ◽  
pp. 30-36 ◽  
Author(s):  
Yusuke Mimura ◽  
Ronan M. Kelly ◽  
Louise Unwin ◽  
Simone Albrecht ◽  
Roy Jefferis ◽  
...  
Keyword(s):  
Cell Lines ◽  
Rodent Cell

Comparison of cytotoxicity and genotoxicity of hi-6 oxime for different human and rodent cell lines

2010 ◽  
Vol 196 ◽  
pp. S255
Author(s):  
H. Svobodova ◽  
P. Jost ◽  
R. Stetina
Keyword(s):  
Cell Lines ◽  
Hi 6 ◽  
Rodent Cell

Evaluation of the direct genotoxic potential of cadmium in four different rodent cell lines

Toxicology ◽  
1998 ◽  
Vol 126 (2) ◽  
pp. 103-114 ◽  
Author(s):  
R.Rita Misra ◽  
George T Smith ◽  
Michael P Waalkes
Keyword(s):  
Cell Lines ◽  
Genotoxic Potential ◽  
Rodent Cell

scholarly journals Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Nicole R Gould ◽  
Katrina M Williams ◽  
Humberto C Joca ◽  
Olivia M Torre ◽  
James S Lyons ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Formation ◽  
Signaling Pathway ◽  
Mouse Models ◽  
Cell Lines ◽  
Mechanical Loading ◽  
Gaucher Disease ◽  
Mechanical Load ◽  
Lysosomal Degradation ◽  
Rodent Cell

The down regulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost gene hours after stimulation. Using mouse models and rodent cell lines, we describe the rapid, minutes-scale post-translational degradation of sclerostin protein by the lysosome following mechanical load and PTH. We present a model, integrating both new and established mechanically- and hormonally-activated effectors into the regulated degradation of sclerostin by lysosomes. Using a mouse forelimb mechanical loading model, we find transient inhibition of lysosomal degradation or the upstream mechano-signaling pathway controlling sclerostin abundance impairs subsequent load-induced bone formation by preventing sclerostin degradation. We also link dysfunctional lysosomes to aberrant sclerostin regulation using human Gaucher disease iPSCs. These results reveal how bone anabolic cues post-translationally regulate sclerostin abundance in osteocytes to regulate bone formation.

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