Epidermal growth factor-like molecular species in normal bronchoalveolar lavage fluid

Lung ◽  
1996 ◽  
Vol 174 (3) ◽  
pp. 171-179 ◽  
Author(s):  
R. K. Kumar ◽  
R. O'Grady ◽  
N. Di Girolamo
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Bronchoalveolar Lavage ◽  
Molecular Species ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Epidermal Growth

scholarly journals Diagnostic value of epidermal growth factor, cancer antigen 125, and cancer antigen 15-3 in bronchoalveolar lavage fluid of lung cancer

2017 ◽  
Vol 24 (3) ◽  
pp. 180 ◽  
Author(s):  
S. Sun ◽  
Z. Chen ◽  
C. Cao ◽  
B. Wu ◽  
B. Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Diagnostic Value ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Epidermal Growth

Aim In the present study, we assessed the diagnostic value of epidermal growth factor (egf) and cancer antigens 125 (ca125) and 15-3 (ca15-3) in bronchoalveolar lavage fluid (balf) of lung cancer from 79 enrolled patients with suspected lung cancer.Methods All patients underwent fibrescopic examination, during which balf samples were collected. Levels of egf, ca125, and ca15-3 were determined in balf using commercially available test kits.Results The results showed that levels of egf in balf were significantly higher in patients with lung cancer than in patients with benign diseases (p < 0.01); no significant differences for ca125 (p = 0.67) or ca15-3 (p = 0.43) in balf were observed between the lung cancer patients and the non-cancer control subjects. With a cut-off value of 27.22 pg/mL, egf showed a sensitivity of 63.6% and a specificity of 65.7% in predicting the malignant nature of pulmonary disease.Conclusions The study findings suggest that levels of egf are significantly increased in balf from patients with lung cancer than in balf from patients with benign disease. Detection of the level of egf in balf is proposed as a non-invasive test to identify patients at high risk for lung cancer.

Transforming growth factor-β1in bronchoalveolar lavage fluid from children with cystic fibrosis

2009 ◽  
Vol 44 (11) ◽  
pp. 1057-1064 ◽  
Author(s):  
William T. Harris ◽  
Marianne S. Muhlebach ◽  
Robert A. Oster ◽  
Michael R. Knowles ◽  
Terry L. Noah
Keyword(s):  
Cystic Fibrosis ◽  
Growth Factor ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Transforming Growth Factor ◽  
Lavage Fluid

Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice

2005 ◽  
Vol 99 (1) ◽  
pp. 298-307 ◽  
Author(s):  
David E. Nethery ◽  
Bethany B. Moore ◽  
George Minowada ◽  
James Carroll ◽  
Jihane A. Faress ◽  
...  
Keyword(s):  
Growth Factor ◽  
Lung Injury ◽  
Transgenic Mice ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Lavage Fluid ◽  
Dominant Negative ◽  
Nontransgenic Littermate

Neuregulin-1 (NRG-1), binding to the human epidermal growth factor receptor HER2/HER3, plays a role in pulmonary epithelial cell proliferation and recovery from injury in vitro. We hypothesized that activation of HER2/HER3 by NRG-1 would also play a role in recovery from in vivo lung injury. We tested this hypothesis using bleomycin lung injury of transgenic mice incapable of signaling through HER2/HER3 due to lung-specific dominant-negative HER3 (DNHER3) expression. In animals expressing DNHER3, protein leak, cell infiltration, and NRG-1 levels in bronchoalveolar lavage fluid increased after injury, similar to that in nontransgenic littermate control animals. However, HER2/HER3 was not activated, and DNHER3 animals displayed fewer lung morphological changes at 10 and 21 days after injury ( P = 0.01). In addition, they contained 51% less collagen in injured lungs ( P = 0.04). Transforming growth factor-β1 did not increase in bronchoalveolar lavage fluid from DNHER3 mice compared with nontransgenic littermate mice ( P = 0.001), suggesting that a mechanism for the decreased fibrosis was lack of transforming growth factor-β1 induction in DNHER3 mice. Severe lung injury (0.08 units bleomycin) resulted in 80% mortality of nontransgenic mice, but only 35% mortality of DNHER3 transgenic mice ( P = 0.04). Thus inhibition of HER2/HER3 signaling protects against pulmonary fibrosis and improves survival.

Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma

2000 ◽  
Vol 278 (2) ◽  
pp. L305-L311 ◽  
Author(s):  
Emma L. Heeley ◽  
Jens M. Hohlfeld ◽  
Norbert Krug ◽  
Anthony D. Postle
Keyword(s):  
Bronchoalveolar Lavage ◽  
Molecular Species ◽  
Bronchoalveolar Lavage Fluid ◽  
Allergen Challenge ◽  
Lavage Fluid ◽  
Ionization Mass ◽  
Control Groups ◽  
Mild Asthmatic ◽  
Surfactant Dysfunction ◽  
And Control

Electrospray ionization mass spectrometry was used to quantify phosphatidylcholine (PC) and phosphatidylglycerol (PG) molecular species in bronchoalveolar lavage fluid (BALF) from control and mild asthmatic subjects after local allergen challenge. BALF was obtained from 5 control and 13 asthmatic subjects before and 24 h after segmental allergen and saline challenge. There were no differences in the ratio of total PC to total PG or in the molecular species composition of PC or PG between the asthmatic and control groups under basal conditions. Allergen challenge in asthmatic but not in control volunteers caused a significant increase in the PC-to-PG ratio because of increased concentrations of PC species containing linoleic acid (16:0/18:2 PC, 18:0/18:2 PC, and 18:1/18:2 PC). These molecular species were characteristic of plasma PC analyzed from the same subjects, strongly suggesting that the altered PC composition in BALF in asthmatic subjects after allergen challenge was due to infiltration of plasma lipoprotein, not to catabolism of surfactant phospholipid. Interactions between surfactant and lipoprotein infiltrate may contribute to surfactant dysfunction and potentiate disease severity in asthma.

scholarly journals Vascular Endothelial Growth Factor in Bronchoalveolar Lavage Fluid in Sulfur Mustard Exposed Lung Patients

2011 ◽  
Vol 26 (2) ◽  
pp. 118-121 ◽  
Author(s):  
Ali Karami ◽  
Mostafa Ghanei ◽  
Farshid Alaeddini ◽  
Mohammad Javad Soltanpour ◽  
Fatemeh Pourali ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Sulfur Mustard ◽  
Lavage Fluid ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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