Effect of dihydroergosine (DHESN) on the serotoninergic system and behaviour: Is DHESN a new antidepressive agent?

1986 ◽  
Vol 90 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Danka Peričié ◽  
Hari Manev ◽  
Sonja Levanat ◽  
Branimi Jernej ◽  
Dunja Vujić ◽  
...  
Keyword(s):  
Serotoninergic System ◽  
Antidepressive Agent

scholarly journals Peripheral Modulators of the Central Fatigue Development and Their Relationship with Athletic Performance in Jumper Horses

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 743
Author(s):  
Francesca Arfuso ◽  
Claudia Giannetto ◽  
Elisabetta Giudice ◽  
Francesco Fazio ◽  
Michele Panzera ◽  
...  
Keyword(s):  
Blood Lactate ◽  
Athletic Performance ◽  
Lactate Concentration ◽  
Indirect Evidence ◽  
Blood Lactate Concentration ◽  
Central Fatigue ◽  
Serotoninergic System ◽  
Stressful Situation ◽  
Passive Behavior ◽  
Fatigue Development

The current study aimed to investigate whether peripheral modulators of serotoninergic function and neurohumoral factors’ changes in athletic horses during an official jumping competition, and to evaluate their relationship with the physical performance of competing horses. From 7 Italian Saddle mares (6–9 years; mean body weight 440 ± 15 kg), performing the same standardized warm-up and jumping course during an official class, heart rate (HR) was monitored throughout the competition. Rectal temperature (RT) measurement, blood lactate and glucose concentration, serum tryptophan, leucine, valine, the tryptophan/branched-chain amino-acids ratio (Try/BCAAs), dopamine, prolactin, and non-esterified fatty acids (NEFAs) were assessed before the exercise event (T0), at the end of the competition stage (5 min ± 10 s following the cessation of the exercise, TPOST5), and 30 min after the end of competition (TPOST30). Highest HR values were recorded during the course and at the outbound (p < 0.0001); blood lactate concentration and RT increased after exercise with respect to the rest condition (p < 0.0001). Lower leucine and valine levels (p < 0.01), and higher tryptophan, Try/BCAAs ratio, and NEFAs values were found at TPOST5 and TPOST30 with respect to T0 (p < 0.0001). A higher prolactin concentration was found at TPOST5 and TPOST30 compared to T0 (p < 0.0001), whereas dopamine showed decreased values after exercise compared to rest (p < 0.0001). Statistically significant correlations among the peripheral indices of serotoninergic function, neurohumoral factors, and athletic performance parameters were found throughout the monitoring period. The findings provide indirect evidence that the serotoninergic system may be involved in fatigue during jumper exercise under a stressful situation, such as competition, in which, in addition to physical effort, athletic horses exhibit more passive behavior.

scholarly journals Effects of caloric vestibular stimulation on serotoninergic system in the media vestibular nuclei of guinea pigs

2007 ◽  
Vol 120 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Fu-rong MA ◽  
Jun-xiu LIU ◽  
Xue-pei LI ◽  
Jian-jun MAO ◽  
Qun-dan ZHANG ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Vestibular Nuclei ◽  
Vestibular Stimulation ◽  
Serotoninergic System ◽  
Caloric Vestibular Stimulation ◽  
The Media

EFFECTS OF SEROTONIN ON SPONTANEOUS OVULATION: A THEORY FOR THE DUAL HYPOTHALAMIC CONTROL OF OVULATION

1971 ◽  
Vol 68 (2) ◽  
pp. 334-344 ◽  
Author(s):  
Anant P. Labhsetwar
Keyword(s):  
Serotoninergic System ◽  
Dual Control ◽  
Inhibitory Effects ◽  
Catecholaminergic System ◽  
Peripheral Mechanism ◽  
Ovulation Inhibition ◽  
Oestradiol Benzoate ◽  
Hypothalamic Control ◽  
Specific Antagonist

ABSTRACT In an attempt to study the inhibitory effects of serotonin on spontaneous ovulation, the monoamine was administered subcutaneously to rats with 4-day oestrous cycles. Administration (50 mg/kg) at 5.00 p. m. on the day before pro-oestrus interfered with ovulation without affecting vaginal cornification, uterine ballooning or mating. This effect on ovulation could be overcome with methysergide, a specific antagonist of serotonin. Administration, at appropriate times, of LH or oestradiol benzoate or the stimulus provided by mating prevented the inhibitory effects of serotonin. implicating a central rather than a peripheral mechanism in interference with ovulation. This was further confirmed by the persistence in the serotonin-treated animals of high levels of pituitary LH, comparable to pro-oestrous levels. It is probable that serotonin blocked ovulation by augmenting the inhibitory effects of serotoninergic fibres in the hypothalamus. It is postulated on the basis of the present results and those reported in the literature that the hypothalamus exercises a dual control over ovulation, inhibitory influences being transmitted through serotonin-linked neurones while stimulatory effects are delivered via catecholaminergic fibres to neurones which synthesize releasing factor(s) for the ovulating hormone. It is postulated that a certain degree of balance in favour of the catecholaminergic system is necessary for the occurrence of ovulation. Inhibition of ovulation occurs whenever the serotoninergic system gains dominance over catecholaminergic system. The theory can account for the effects on ovulation of a multitude of chemically diverse agents reported in the literature.

Serotoninergic control of prolactin secretion in prepubertal male rats

1994 ◽  
Vol 131 (5) ◽  
pp. 547-554 ◽  
Author(s):  
Enrique Aguilar ◽  
Antonio Ranchal ◽  
Manuel Tena-Sempere ◽  
Leonor Pinilla
Keyword(s):  
Specific Inhibitor ◽  
Prolactin Secretion ◽  
Male Rats ◽  
Serotoninergic System ◽  
Selective Agonist ◽  
5 Ht Uptake ◽  
Releasing Effect

Aguilar E, Ranchal A, Tena-Sempere M, Pinilla L. Serotoninergic control of prolactin secretion in prepubertal male rats. Eur J Endocrinol 1994;131:547–54. ISSN 0804–4643 The role of the serotoninergic system in the control of prolactin (PRL) secretion has been studied in prepubertal male rats. Serum PRL concentration was measured in 16-day-old male rats at different times after the administration of 5-hydroxytryptophan (5-HTP), a precursor of serotonin (5-HT) synthesis, alone or in combination with fluoxetine, a specific inhibitor of 5-HT uptake; dl-p-parachlorophenylalanine (PCPA), an inhibitor of 5-HT synthesis; and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective agonist of 5-HT1A receptors. Also, serum PRL concentration and pituitary content were measured after 5-HTP administration in castrated males implanted with silastic capsules containing testosterone or 5α-androstane-3α,17β-diol (α-diol). We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after α-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or α-diol. Therefore, we conclude that: the PRL-releasing effect of 5-HTP remains after orchidectomy; activation of 5-HT1A receptors may mediate, at least partially, the effect of 5-HTP; testosterone and α-diol affect the duration of PRL release after 5-HTP administration differently; and testicular factors other than androgens might be involved in the effects of 5-HTP on PRL pituitary accumulation. Enrique Aguilar, Department of Physiology, Faculty of Medicine, Córdoba University, 14004 Córdoba, Spain

Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder

2019 ◽  
Vol 271 ◽  
pp. 554-558 ◽  
Author(s):  
Maria Teresa Plana ◽  
Teresa Torres ◽  
Natalia Rodríguez ◽  
Daniel Boloc ◽  
Patricia Gassó ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Genetic Variability ◽  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Serotoninergic System ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Monoaminergic and Opioidergic Modulation of Brainstem Circuits: New Insights Into the Clinical Challenges of Pain Treatment?

2021 ◽  
Vol 2 ◽  
Author(s):  
Isaura Tavares ◽  
José Tiago Costa-Pereira ◽  
Isabel Martins
Keyword(s):  
Neuropathic Pain ◽  
Pain Control ◽  
Pain Treatment ◽  
Reticular Nucleus ◽  
Serotoninergic System ◽  
High Plasticity ◽  
Descending Facilitation ◽  
Pain Models ◽  
Dual Action ◽  
Control Circuits

The treatment of neuropathic pain remains a clinical challenge. Analgesic drugs and antidepressants are frequently ineffective, and opioids may induce side effects, including hyperalgesia. Recent results on brainstem pain modulatory circuits may explain those clinical challenges. The dual action of noradrenergic (NA) modulation was demonstrated in animal models of neuropathic pain. Besides the well-established antinociception due to spinal effects, the NA system may induce pronociception by directly acting on brainstem pain modulatory circuits, namely, at the locus coeruleus (LC) and medullary dorsal reticular nucleus (DRt). The serotoninergic system also has a dual action depending on the targeted spinal receptor, with an exacerbated activity of the excitatory 5-hydroxytryptamine 3 (5-HT3) receptors in neuropathic pain models. Opioids are involved in the modulation of descending modulatory circuits. During neuropathic pain, the opioidergic modulation of brainstem pain control areas is altered, with the release of enhanced local opioids along with reduced expression and desensitization of μ-opioid receptors (MOR). In the DRt, the installation of neuropathic pain increases the levels of enkephalins (ENKs) and induces desensitization of MOR, which may enhance descending facilitation (DF) from the DRt and impact the efficacy of exogenous opioids. On the whole, the data discussed in this review indicate the high plasticity of brainstem pain control circuits involving monoaminergic and opioidergic control. The data from studies of these neurochemical systems in neuropathic models indicate the importance of designing drugs that target multiple neurochemical systems, namely, maximizing the antinociceptive effects of antidepressants that inhibit the reuptake of serotonin and noradrenaline and preventing desensitization and tolerance of MOR at the brainstem.

Smooth Muscle Stimulation by an Immunomodulatory Compound Muramyl Dipeptide: Does It Involve Serotoninergic System?

Pharmacology ◽  
1984 ◽  
Vol 29 (1) ◽  
pp. 31-39 ◽  
Author(s):  
O. Kadlec ◽  
K. Ma&scaron;ek ◽  
O. Gulda ◽  
V. R&uring;&zcaron;i&ccaron;ka ◽  
M. Parant ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muramyl Dipeptide ◽  
Serotoninergic System ◽  
Muscle Stimulation

Effects of S 9977, a potential antimigraine drug, on the central serotoninergic system of the rat

1990 ◽  
Vol 183 (5) ◽  
pp. 1922 ◽  
Author(s):  
F. Héry ◽  
M. Faudon ◽  
E. Mocaër ◽  
M. Héry
Keyword(s):  
Serotoninergic System
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