Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism

1992 ◽  
Vol 13 (2) ◽  
pp. 119-130 ◽  
Author(s):  
HJJA Bernsen ◽  
A Heerschap ◽  
AJ van der Kogel ◽  
JJ van Vaals ◽  
MJJ Prick ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
1H Nmr ◽  
Tumor Model ◽  
Human Brain Tumor ◽  
New Approach ◽  
Nude Rat ◽  
Image Guided ◽  
Brain Tumor Model

scholarly journals Comprehensive Glycomics of a Multistep Human Brain Tumor Model Reveals Specific Glycosylation Patterns Related to Malignancy

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0128300 ◽  
Author(s):  
Jun-ichi Furukawa ◽  
Masumi Tsuda ◽  
Kazue Okada ◽  
Taichi Kimura ◽  
Jinhua Piao ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Tumor Model ◽  
Human Brain Tumor ◽  
Brain Tumor Model

The characterization of human brain tumor using magnetization transfer technique in magnetic resonance imaging

1999 ◽  
Vol 21 (3) ◽  
pp. 250-254 ◽  
Author(s):  
Ayumi Okumura ◽  
Katsunobu Takenaka ◽  
Yasuaki Nishimura ◽  
Yoshitaka Asano ◽  
Noboru Sakai ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Brain Tumor ◽  
Magnetic Resonance ◽  
Human Brain ◽  
Magnetization Transfer ◽  
Resonance Imaging ◽  
Human Brain Tumor

scholarly journals Magnetic Resonance Microscopy at 14 Tesla and Correlative Histopathology of Human Brain Tumor Tissue

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27442 ◽  
Author(s):  
Ana Gonzalez-Segura ◽  
Jose Manuel Morales ◽  
Jose Manuel Gonzalez-Darder ◽  
Ramon Cardona-Marsal ◽  
Concepcion Lopez-Gines ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Magnetic Resonance ◽  
Human Brain ◽  
Tumor Tissue ◽  
Magnetic Resonance Microscopy ◽  
Human Brain Tumor

Quantitative Measurements of Regional Glucose Utilization and Rate of Valine Incorporation into Proteins by Double-Tracer Autoradiography in the Rat Brain Tumor Model

1989 ◽  
Vol 9 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Michihiro Kirikae ◽  
Mirko Diksic ◽  
Y. Lucas Yamamoto
Keyword(s):  
Protein Synthesis ◽  
Brain Tumor ◽  
Rat Brain ◽  
Brain Tissue ◽  
Glucose Utilization ◽  
Tumor Model ◽  
Normal Brain ◽  
Normal Brain Tissue ◽  
Rat Brain Tumor ◽  
Brain Tumor Model

We examined the rate of glucose utilization and the rate of valine incorporation into proteins using 2-[18F]fluoro-2-deoxyglucose and L-[1-14C]-valine in a rat brain tumor model by quantitative double-tracer autoradiography. We found that in the implanted tumor the rate of valine incorporation into proteins was about 22 times and the rate of glucose utilization was about 1.5 times that in the contralateral cortex. (In the ipsilateral cortex, the tumor had a profound effect on glucose utilization but no effect on the rate of valine incorporation into proteins.) Our findings suggest that it is more useful to measure protein synthesis than glucose utilization to assess the effectiveness of antitumor agents and their toxicity to normal brain tissue. We compared two methods to estimate the rate of valine incorporation: “kinetic” (quantitation done using an operational equation and the average brain rate coefficients) and “washed slices” (unbound labeled valine removed by washing brain slices in 10% thrichloroacetic acid). The results were the same using either method. It would seem that the kinetic method can thus be used for quantitative measurement of protein synthesis in brain tumors and normal brain tissue using [11C]-valine with positron emission tomography.

scholarly journals A New Approach to Characterization of Insulin Derived from Different Species Using 1H-NMR Coupled with Multivariate Analysis

2012 ◽  
Vol 60 (3) ◽  
pp. 320-324 ◽  
Author(s):  
Akiko Ohno ◽  
Toru Kawanishi ◽  
Haruhiro Okuda ◽  
Kiyoshi Fukuhara
Keyword(s):  
Multivariate Analysis ◽  
1H Nmr ◽  
New Approach

Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors

1994 ◽  
Vol 81 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Takao Nakagawa ◽  
Toshihiko Kubota ◽  
Masanori Kabuto ◽  
Kazufumi Sato ◽  
Hirokazu Kawano ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Matrix Metalloproteinases ◽  
Brain Tumors ◽  
Human Brain ◽  
Tumor Cells ◽  
Tumor Invasion ◽  
Gelatinolytic Activity ◽  
Normal Brain ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Human Brain Tumor

✓ The role of matrix metalloproteinases (MMP's) and their inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1), in human brain tumor invasion was investigated. Gelatinolytic activity was assayed via gelatin zymography, and four MMP's (MMP-1, MMP-2, MMP-3, and MMP-9) and TIMP-1 were immunolocalized in human brain tumors and in normal brain tissues using monoclonal antibodies. The tissue was surgically removed from 44 patients: glioblastoma (five cases), anaplastic astrocytoma (six cases), astrocytoma (four cases), metastatic tumor (six cases), neurinoma (10 cases), meningioma (10 cases), and normal brain tissue (three cases). Glioblastomas, anaplastic astrocytomas, and metastatic tumors showed high gelatinolytic activity and positive immunostaining for MMP's; TIMP-1 was also expressed in these tumors, but some tumor cells were negative for the antibody. Astrocytomas had low gelatinolytic activity and the tumor cells showed no immunoreactivity for MMP's and TIMP-1. Although neurinomas and meningiomas had only moderate proteinase activity and exhibited positive immunoreactivity for MMP-9, intense expression of TIMP-1 was simultaneously observed in these tumor cells. These findings suggest that MMP's play an important role in human brain tumor invasion, probably due to an imbalance between the production of MMP's and TIMP-1 by the tumor cells.

scholarly journals Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients

2016 ◽  
Vol 18 (9) ◽  
pp. 1209-1218 ◽  
Author(s):  
Amy K. LeBlanc ◽  
Christina Mazcko ◽  
Diane E. Brown ◽  
Jennifer W. Koehler ◽  
Andrew D. Miller ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Tumor Patients ◽  
Human Brain Tumor ◽  
New Knowledge
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