Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins

1995 ◽  
Vol 41 (5) ◽  
Author(s):  
AustinL. Hughes ◽  
MarianneK. Hughes
Keyword(s):  
Hla Class I ◽  
Class I ◽  
Conserved Regions ◽  
Hla Class I Molecules ◽  
Evolutionarily Conserved ◽  
Self Peptides

Amnion Epithelial Cells, in Contrast to Trophoblast Cells, Express All Classical HLA Class I Molecules Together With HLA-G

1997 ◽  
Vol 37 (2) ◽  
pp. 161-171 ◽  
Author(s):  
Astrid Hammer ◽  
Heinz Hutter ◽  
Astrid Blaschitz ◽  
Wolfgang Mahnert ◽  
Michaele Hartmann ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Hla Class I ◽  
Class I ◽  
Trophoblast Cells ◽  
Hla Class I Molecules ◽  
Amnion Epithelial Cells

Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules

1997 ◽  
Vol 155 (1) ◽  
pp. 165-174 ◽  
Author(s):  
Miguel Lopez-Botet ◽  
Juan J. Perez-Villar ◽  
Marta Carretero ◽  
Antonio Rodriguez ◽  
Ignacio Melero ◽  
...  
Keyword(s):  
Hla Class I ◽  
Structure And Function ◽  
Class I ◽  
Receptor Complex ◽  
Lectin Receptor ◽  
Hla Class I Molecules ◽  
And Function

scholarly journals Favorable and Unfavorable HLA Class I Alleles and Haplotypes in Zambians Predominantly Infected with Clade C Human Immunodeficiency Virus Type 1

2002 ◽  
Vol 76 (16) ◽  
pp. 8276-8284 ◽  
Author(s):  
Jianming Tang ◽  
Shenghui Tang ◽  
Elena Lobashevsky ◽  
Angela D. Myracle ◽  
Ulgen Fideli ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Hla Class I ◽  
Class I ◽  
Hla Class I Molecules ◽  
Immunodeficiency Virus ◽  
Clade C ◽  
Hiv 1

ABSTRACT The setpoint of viral RNA concentration (viral load [VL]) during chronic human immunodeficiency virus type 1 (HIV-1) infection reflects a virus-host equilibration closely related to CD8+ cytotoxic T-lymphocyte (CTL) responses, which rely heavily on antigen presentation by the human major histocompatibility complex (MHC) (i.e., HLA) class I molecules. Differences in HIV-1 VL among 259 mostly clade C virus-infected individuals (137 females and 122 males) in the Zambia-UAB HIV Research Project (ZUHRP) were associated with several HLA class I alleles and haplotypes. In particular, general linear model analyses revealed lower log10 VL among those with HLA allele B*57 (P = 0.002 [without correction]) previously implicated in favorable response and in those with HLA B*39 and A*30-Cw*03 (P = 0.002 to 0.016); the same analyses also demonstrated higher log10 VL among individuals with A*02-Cw*16, A*23-B*14, and A*23-Cw*07 (P = 0.010 to 0.033). These HLA effects remained strong (P = 0.0002 to 0.075) after adjustment for age, gender, and duration of infection and persisted across three orders of VL categories (P = 0.001 to 0.084). In contrast, neither B*35 (n = 15) nor B*53 (n = 53) showed a clear disadvantage such as that reported elsewhere for these closely related alleles. Other HLA associations with unusually high (A*68, B*41, B*45, and Cw*16) or low (B*13, Cw*12, and Cw*18) VL were either unstable or reflected their tight linkage respecting disequilibria with other class I variants. The three consistently favorable HLA class I variants retained in multivariable models and in alternative analyses were present in 30.9% of subjects with the lowest (<10,000 copies per ml) and 3.1% of those with the highest (>100,000) VL. Clear differential distribution of HLA profiles according to level of viremia suggests important host genetic contribution to the pattern of immune control and escape during HIV-1 infection.

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