Heterogeneous responses of an in vitro model of human stomach cancer to anticancer drugs

1983 ◽  
Vol 1 (2) ◽  
pp. 117-127 ◽  
Author(s):  
S. C. Barranco ◽  
C. M. Townsend ◽  
M. A. Quraishi ◽  
N. L. Burger ◽  
H. C. Nevill ◽  
...  
Keyword(s):  
Stomach Cancer ◽  
Anticancer Drugs ◽  
In Vitro Model ◽  
Human Stomach ◽  
Vitro Model ◽  
Human Stomach Cancer

Association of Extracellular Cleavage of E-Cadherin Mediated by MMP-7 with HGF-Induced in vitro Invasion in Human Stomach Cancer Cells

2007 ◽  
Vol 39 (4) ◽  
pp. 208-215 ◽  
Author(s):  
K.H. Lee ◽  
E.Y. Choi ◽  
M.S. Hyun ◽  
B.I. Jang ◽  
T.N. Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Stomach Cancer ◽  
Human Stomach ◽  
In Vitro Invasion ◽  
Human Stomach Cancer ◽  
E Cadherin

scholarly journals Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 184
Author(s):  
Chia-Chen Ku ◽  
Kenly Wuputra ◽  
Jia-Bin Pan ◽  
Chia-Pei Li ◽  
Chung-Jung Liu ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Stem Cell ◽  
Stomach Cancer ◽  
Anticancer Agents ◽  
Three Dimensional ◽  
Human Stomach ◽  
Human Stomach Cancer ◽  
Stem Cell Niches

There is considerable cellular diversity in the human stomach, which has helped to clarify cell plasticity in normal development and tumorigenesis. Thus, the stomach is an interesting model for understanding cellular plasticity and for developing prospective anticancer therapeutic agents. However, many questions remain regarding the development of cancers in vivo and in vitro in two- or three-dimensional (2D/3D) cultures, as well as the role of Helicobacter pylori (H. p.) infection. Here, we focus on the characteristics of cancer stem cells and their derived 3D organoids in culture, including the formation of stem cell niches. We define the conditions required for such organoid culture in vitro and examine the ability of such models for testing the use of anticancer agents. We also summarize the signaling cascades and the specific markers of stomach-cancer-derived organoids induced by H. p. infection, and their stem cell niches.

scholarly journals Integrated transcriptome and in vitro analysis revealed anti-proliferative effect of citral in human stomach cancer through apoptosis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sri Renukadevi Balusamy ◽  
Sivasubramanian Ramani ◽  
Sathishkumar Natarajan ◽  
Yeon Ju Kim ◽  
Haribalan Perumalsamy
Keyword(s):  
Stomach Cancer ◽  
Human Stomach ◽  
Proliferative Effect ◽  
Vitro Analysis ◽  
Human Stomach Cancer ◽  
In Vitro Analysis

scholarly journals Anticancer and Antioxidant Activity of Bread Enriched with Broccoli Sprouts

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Urszula Gawlik-Dziki ◽  
Michał Świeca ◽  
Dariusz Dziki ◽  
Łukasz Sęczyk ◽  
Urszula Złotek ◽  
...  
Keyword(s):  
Stomach Cancer ◽  
Cancer Chemoprevention ◽  
Food Supplement ◽  
Human Stomach ◽  
Antioxidant Potential ◽  
Broccoli Sprouts ◽  
Simulated Digestion ◽  
Human Stomach Cancer ◽  
Upper Gastrointestinal

This study is focused on antioxidant and anticancer capacity of bread enriched with broccoli sprouts (BS) in the light of their potential bioaccessibility and bioavailability. Generally, bread supplementation elevated antioxidant potential of product (both nonenzymatic and enzymatic antioxidant capacities); however, the increase was not correlated with the percent of BS. A replacement up to 2% of BS gives satisfactory overall consumers acceptability and desirable elevation of antioxidant potential. High activity was especially found for extracts obtained after simulated digestion, which allows assuming their protective effect for upper gastrointestinal tract; thus, the anticancer activity against human stomach cancer cells (AGS) was evaluated. A prominent cytostatic response paralleled by the inhibition of AGS motility in the presence of potentially mastication-extractable phytochemicals indicates that phenolic compounds of BS retain their biological activity in bread. Importantly, the efficient phenolics concentration was about 12 μM for buffer extract, 13 μM for extracts after digestionin vitro, and 7 μM for extract after absorptionin vitro. Our data confirm chemopreventive potential of bread enriched with BS and indicate that BS comprise valuable food supplement for stomach cancer chemoprevention.

In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer

Phytomedicine ◽  
2018 ◽  
Vol 46 ◽  
pp. 119-130 ◽  
Author(s):  
Haribalan Perumalsamy ◽  
Karuppasamy Sankarapandian ◽  
Karpagam Veerappan ◽  
Sathishkumar Natarajan ◽  
Narendran Kandaswamy ◽  
...  
Keyword(s):  
Stomach Cancer ◽  
In Silico ◽  
Coumarin Derivative ◽  
Human Stomach ◽  
Intrinsic Pathway ◽  
Anticancer Effects ◽  
Vitro Analysis ◽  
Human Stomach Cancer ◽  
In Vitro Analysis

The inhibitory effect of amiloride on the growth of human stomach cancer cells in vitro

2000 ◽  
Vol 118 (4) ◽  
pp. A520
Author(s):  
Jayoung Koo ◽  
Duckkyung Kong ◽  
Mooin Park ◽  
Seonja Park ◽  
Keunoh Chung ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Stomach Cancer ◽  
Inhibitory Effect ◽  
Human Stomach ◽  
Human Stomach Cancer

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

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