L-type calcium channel activity in human atrial myocytes as influenced by 5-HT

1993 ◽  
Vol 348 (4) ◽  
Author(s):  
Ulrich Jahnel ◽  
Hermann Nawrath ◽  
Johanna Rupp ◽  
Rikuo Ochi
Keyword(s):  
Calcium Channel ◽  
Channel Activity ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes

scholarly journals Sarcoplasmic reticulum and L-type Ca2+channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytes

2011 ◽  
Vol 589 (13) ◽  
pp. 3247-3262 ◽  
Author(s):  
Anna Llach ◽  
Cristina E. Molina ◽  
Jacqueline Fernandes ◽  
Josep Padró ◽  
Juan Cinca ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Calcium Handling ◽  
Channel Activity ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes

Acetylcholine-sensitive potassium channels in human atrial myocytes

1990 ◽  
Vol 259 (6) ◽  
pp. H1730-H1735 ◽  
Author(s):  
R. Sato ◽  
I. Hisatome ◽  
J. A. Wasserstrom ◽  
C. E. Arentzen ◽  
D. H. Singer
Keyword(s):  
Single Channel ◽  
K Channel ◽  
Channel Activity ◽  
Atrial Myocytes ◽  
Open Probability ◽  
Human Atrial Myocytes ◽  
Open Time ◽  
Patch Pipette ◽  
Single Channel Activity ◽  
Gamma S

Single channel recording techniques were used to study acetylcholine (ACh)-sensitive K+ channel activity in human atrial myocytes isolated from specimens obtained during corrective cardiac surgery. Under conditions of cell-attached patch, the presence of ACh in the patch pipette activated K+ channels. Single channel activity occurred in periodic bursts. The channels exhibited a slope conductance of 46 +/- 2 pS inwardly (means +/- SD, n = 4). During a burst, both open and closed time histograms were fitted by a single exponential curve, suggesting the existence of one open and one closed state during a burst. Open probability increased directly with ACh concentration without affecting open time. The channel could be activated by GTP and guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) (in the presence and absence of ACh in the pipette, respectively). Slope conductance, the response to GTP and GTP gamma S, and the independence of activation from Ca2+ were similar to those for other species. In contrast, sensitivity to ACh appeared diminished compared with frog atrial myocytes.

Src family tyrosine kinases inhibit single L-type: Ca2+channel activity in human atrial myocytes

2004 ◽  
Vol 37 (3) ◽  
pp. 735-745 ◽  
Author(s):  
Frank Schröder ◽  
Gunnar Klein ◽  
Tanja Frank ◽  
Michaela Bastein ◽  
Sylvio Indris ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Channel Activity ◽  
Atrial Myocytes ◽  
Human Atrial Myocytes ◽  
Src Family Tyrosine Kinases

scholarly journals Glucose-6-Phosphate Dehydrogenase and NADPH Redox Regulates Cardiac Myocyte L-Type Calcium Channel Activity and Myocardial Contractile Function

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e45365 ◽  
Author(s):  
Dhwajbahadur K. Rawat ◽  
Peter Hecker ◽  
Makino Watanabe ◽  
Sukrutha Chettimada ◽  
Richard J. Levy ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Cardiac Myocyte ◽  
Contractile Function ◽  
Channel Activity ◽  
Myocardial Contractile ◽  
Glucose 6 Phosphate Dehydrogenase
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