Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci

1995 ◽  
Vol 41 (2) ◽  
Author(s):  
Tomoko Ohta
Keyword(s):  
Major Histocompatibility Complex ◽  
Gene Conversion ◽  
Point Mutation ◽  
Antigen Recognition ◽  
Recognition Site ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Antigen Recognition Site

scholarly journals Antigen recognition by a T cell clone outside the context of the major histocompatibility complex. A role for Mls in antigen presentation.

1984 ◽  
Vol 159 (1) ◽  
pp. 305-312 ◽  
Author(s):  
S J Waters ◽  
S D Waksal ◽  
G P Norton ◽  
C A Bona
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Cell Clone ◽  
Antigen Recognition ◽  
Major Histocompatibility ◽  
Spleen Cells ◽  
Differentiation Markers ◽  
Histocompatibility Complex ◽  
T Cell Clone

A T cell clone isolated from antigen-primed CB6/F1 mice was shown to proliferate to keyhole limpet hemocyanin (KLH) in the presence of irradiated syngeneic F1 spleen cells, as well as spleen cells from either parental strain (BALB/c and C57BL/6). The genetic restriction involved in this antigen-specific proliferation was mapped using BXD (C57BL/6 X DBA/2) recombinant inbred strains of mice to the Mls gene on chromosome one. To exclude the role of Ia antigens as the restricting determinants, monoclonal anti-Ia antibodies were used to block the in vitro proliferative response of this clone. Although anti-Iab and anti-Iad blocked the proliferation of this clone to KLH in the presence of irradiated spleen cells from either parent, this effect was shown to be dependent on Ia molecules passively absorbed by the T cell clone from the irradiated filler cells. Since the T clone expressed Thy-1.2 and Lyt-1+ differentiation markers, its helper activity was compared with other KLH carrier-specific clones in an in vitro antibody synthesis assay. The Mls-KLH-restricted T cell clone, in contrast to other carrier-specific, major histocompatibility complex (MHC)-restricted T cell clones, was unable to cooperate with trinitrophenyl (TNP)-primed B cells in the presence of TNP-KLH to generate an anti-TNP response. These experiments suggest that non-MHC determinants, such as autologous Mls gene products, may play a role in genetically restricted antigen recognition by T lymphocytes.

scholarly journals Gene conversion of the major histocompatibility complex class I Caja-G in common marmosets (Callithrix jacchus)

Immunology ◽  
2016 ◽  
Vol 149 (3) ◽  
pp. 343-352 ◽  
Author(s):  
Anna-Lena Neehus ◽  
Joachim Wistuba ◽  
Nektarios Ladas ◽  
Britta Eiz-Vesper ◽  
Stefan Schlatt ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Gene Conversion ◽  
Callithrix Jacchus ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Common Marmosets ◽  
Histocompatibility Complex

scholarly journals Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

2008 ◽  
Vol 283 (35) ◽  
pp. 24254-24263 ◽  
Author(s):  
Jean-Manuel Segura ◽  
Philippe Guillaume ◽  
Silke Mark ◽  
Danijel Dojcinovic ◽  
Alexandre Johannsen ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Complex I ◽  
Antigen Recognition ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Peptide Complexes ◽  
Major Histocompatibility Complex I

Gene conversion rapidly generates major histocompatibility complex diversity in recently founded bird populations

2011 ◽  
Vol 20 (24) ◽  
pp. 5213-5225 ◽  
Author(s):  
LEWIS G. SPURGIN ◽  
COCK Van OOSTERHOUT ◽  
JUAN CARLOS ILLERA ◽  
STEPHEN BRIDGETT ◽  
KARIM GHARBI ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Gene Conversion ◽  
Major Histocompatibility ◽  
Major Histocompatibility Complex Diversity ◽  
Bird Populations ◽  
Histocompatibility Complex
Sign in / Sign up

Export Citation Format

Share Document