Structure and activity relationship of several novel CC-1065 analogs

1987 ◽  
Vol 5 (4) ◽  
Author(s):  
LiH. Li ◽  
TanyaL. Wallace ◽  
ThomasF. DeKoning ◽  
MarthaA. Warpehoski ◽  
RobertC. Kelly ◽  
...  
Keyword(s):  
Activity Relationship ◽  
Relationship Of ◽  
Structure And Activity

scholarly journals FLAVONES AND FLAVANONES AS ACHETYLCHOLINESTERASE INHIBITORS: THE STRUCTURE-ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING STUDIES

2021 ◽  
Vol 59 (4) ◽  
pp. 441
Author(s):  
Hoàng Thị Kim Dung ◽  
Hoang-Phuc Nguyen ◽  
Thi-Kim-Chi Huynh
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Docking Studies ◽  
Activity Relationship ◽  
Binding Modes ◽  
Flower Buds ◽  
Molecular Docking Study ◽  
Structure Activity ◽  
Relationship Of ◽  
Structure And Activity

Discovering and developing drugs to treat Alzheimer's disease (AD) have been a crucial target for many decades. According to a large number of later studies, acetylcholinesterase (AChE) plays an important role in AD treatment. On the other hand, flavonoids are natural compounds that possessed a wide variety of bioactivities, including the inhibitory activity on AChE. In this study, we reported the structure and activity relationship of flavone and flavanone derivatives that semi-synthesized and synthesized from flower buds of Styphnolobium japonicum (Leguminosae) and citrus peels against AChE. The results showed that the introducing of the new functional groups that leads to increasing 3-folds better AChE inhibition of compound Q2 and Q4 than that of the original. The molecular docking study was investigated in order to illuminate the experimental results and find their binding modes.

scholarly journals Structure–activity relationship of surface hydroxyl groups during NO2 adsorption and transformation on TiO2 nanoparticles

2017 ◽  
Vol 4 (12) ◽  
pp. 2388-2394 ◽  
Author(s):  
Chang Liu ◽  
Qingxin Ma ◽  
Hong He ◽  
Guangzhi He ◽  
Jinzhu Ma ◽  
...  
Keyword(s):  
Tio2 Nanoparticles ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Hydroxyl Groups ◽  
Surface Hydroxyl ◽  
Surface Hydroxyl Groups ◽  
Structure Activity ◽  
No2 Adsorption ◽  
Relationship Of ◽  
Structure And Activity

The structure and activity of surface hydroxyl groups determined the performance of TiO2 during NO2 reaction.

Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors

2011 ◽  
Vol 21 (5) ◽  
pp. 1456-1458 ◽  
Author(s):  
Masafumi Komiya ◽  
Shigehiro Asano ◽  
Nobuyuki Koike ◽  
Erina Koga ◽  
Junetsu Igarashi ◽  
...  
Keyword(s):  
Activity Relationship ◽  
Relationship Of ◽  
Structure And Activity
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