The inhibitory effects of the novel calcium antagonist Goe 5438 on calcium-dependent processes of excitation and contraction of single cardiomyocytes

1988 ◽  
Vol 337 (4) ◽  
Author(s):  
B. Koid ◽  
B. Wagner ◽  
H.A. Tritthart
Keyword(s):  
Calcium Antagonist ◽  
The Novel ◽  
Inhibitory Effects ◽  
Calcium Dependent ◽  
Dependent Processes

scholarly journals microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2

2021 ◽  
Vol 20 ◽  
pp. 153303382199000
Author(s):  
Gaolian Zhang ◽  
Meng Xia ◽  
Jianhui Guo ◽  
Yi Huang ◽  
Jianrong Huang ◽  
...  
Keyword(s):  
Glioma Cell ◽  
Karnofsky Performance Scale ◽  
The Novel ◽  
Inhibitory Effects ◽  
Aberrant Expression ◽  
Who Grade ◽  
Glioma Cell Proliferation ◽  
Mrna And Protein Expression ◽  
Induced Apoptosis ◽  
Tumor Suppressive Function

Aberrant expression of microRNAs (miRNAs) has been reported to play a role in tumorigenesis. Dysfunction of miR-1296 was found in a variety of cancers, however, the function of miR-1296 in the progression of glioma remains largely understood. Here, our results showed that miR-1296 was significantly down-regulated in glioma tissues and cell lines. Decreased expression of miR-1296 was associated with the tumor size, WHO grade and karnofsky performance scale (KPS) of glioma patients. Low expression of miR-1296 was significantly correlated with the shorter 5-year overall survival of glioma patients. Overexpression of miR-1296 inhibited the proliferation, colony formation, migration and induced apoptosis of glioma cells. MiR-1296 was found to bind the 3’-untranslated region (UTR) of ABL proto-oncogene 2 (ABL2) and subsequently repressed both the mRNA and protein expression of ABL2. ABL2 was overexpressed in glioma tissues and inversely correlated with that of miR-1296. Ectopic expressed ABL2 could reverse the inhibitory effects of miR-1296 on glioma cell proliferation. Our results illustrated the novel tumor-suppressive function of miR-1296 in glioma via repressing ABL2, suggesting a potential application of miR-1296 in the treatment of glioma.

Hemodynamic and humoral effects of the novel calcium antagonist Ro 40-5967 in patients with hypertension

1992 ◽  
Vol 52 (3) ◽  
pp. 314-323 ◽  
Author(s):  
Rita Schmitt ◽  
Cornells H Kleinbloesem ◽  
Gustav G Belz ◽  
Volkmar Schroeter ◽  
Ulrich Feifel ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
The Novel

scholarly journals Methamphetamine increases dopamine release in the nucleus accumbens through calcium-dependent processes

2020 ◽  
Vol 237 (5) ◽  
pp. 1317-1330 ◽  
Author(s):  
Jordan T. Yorgason ◽  
David M. Hedges ◽  
J. Daniel Obray ◽  
Eun Young Jang ◽  
Kyle B. Bills ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Calcium Dependent ◽  
Dependent Processes

scholarly journals A Novel Ag-N-Heterocyclic Carbene Complex Bearing the Hydroxyethyl Ligand: Synthesis, Characterization, Crystal and Spectral Structures and Bioactivity Properties

Crystals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 171 ◽  
Author(s):  
Aydin Aktas ◽  
Duygu Barut Celepci ◽  
Yetkin Gok ◽  
Parham Taslimi ◽  
Hulya Akincioglu ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Diffraction Method ◽  
Metabolic Enzymes ◽  
The Novel ◽  
X Ray Diffraction ◽  
Inhibitory Effects ◽  
Benzimidazolium Salt ◽  
Drug Potency ◽  
Human Carbonic Anhydrase

In this study, a novel silver N-heterocyclic carbene (Ag-NHC) complex bearing hydroxyethyl substituent has been synthesized from the hydroxyethyl-substituted benzimidazolium salt and silver oxide by using in-situ deprotonation method. A structure of the Ag-NHC complex was characterized by using UV-Vis, FTIR, 1H-NMR and 13C-NMR spectroscopies and elemental analysis techniques. Also, the crystal structure of the novel complex was determined by single-crystal X-ray diffraction method. In this paper, compound 1 showed excellent inhibitory effects against some metabolic enzymes. This complex had Ki of 1.14 0.26 µM against human carbonic anhydrase I (hCA I), 1.88±0.20 µM against human carbonic anhydrase II (hCA I), and 10.75±2.47 µM against α-glycosidase, respectively. On the other hand, the Ki value was found as 25.32±3.76 µM against acetylcholinesterase (AChE) and 41.31±7.42 µM against butyrylcholinesterase (BChE), respectively. These results showed that the complex had drug potency against some diseases related to using metabolic enzymes.

Annexin 1 and neutrophil apoptosis

2004 ◽  
Vol 32 (3) ◽  
pp. 507-510 ◽  
Author(s):  
M. Perretti ◽  
E. Solito
Keyword(s):  
Inflammatory Response ◽  
Binding Proteins ◽  
Neutrophil Apoptosis ◽  
The Novel ◽  
Inhibitory Effects ◽  
Phospholipid Binding ◽  
Annexin 1 ◽  
Anti Inflammatory ◽  
Leucocyte Recruitment ◽  
Host Inflammatory Response

ANXA1 (annexin 1), a member of the ‘annexin’ family of calcium- and phospholipid-binding proteins, was originally identified as an endogenous mediator of the anti-inflammatory actions of glucocorticoids. However, this protein exerts multiple inhibitory effects on the host inflammatory response, including a preferential regulation of the adhesion step of blood-borne neutrophil within the microenvironment of an inflamed vasculature. It is now emerging that ANXA1 is endowed with other roles, since the protein is abundant in inflammatory exudates as it is produced and released by the extravasated neutrophil. In the present paper, we review the novel proapoptotic effect of ANXA1 and discuss its potential with respect to the pathophysiology of inflammation and leucocyte recruitment.

The Novel Coronavirus: A Major Global Health Concern

2020 ◽  
Vol 8 (1) ◽  
Keyword(s):  
Care Staff ◽  
Health Concern ◽  
Health Care Staff ◽  
The Novel ◽  
Risk Of Infection ◽  
Inhibitory Effects ◽  
Runny Nose ◽  
Novel Coronavirus ◽  
Nucleoprotein N ◽  
The City

Today, Coronavirus (Cov) is one of the most dangerous diseases worldwide, and many people suffer from it. Coronavirus as a deadly virus was first recognized and spread in the City of Wuhan, Province of Hubei, China. This virion contains nucleocapsid, which is consists of phosphorylated nucleoprotein (N) and genomic RNA. The RNA of coronaviruses is enveloped, not fragmented, and is a positively sensitive single-stranded RNA that is known to be the largest viral genome in various sizes from 26 to 32 kV. Cov usually tends to provoke mild to severe respiratory disease. The symptoms of Cov may comprise headache, cough, fever, sore throat, runny nose, and a discomfort sensation. People with chronic diseases and health care staff are at greater risk of infection. Some compounds, such as mycophenolic acid and cyclosporine A, RNAi, and monoclonal antibodies have shown inhibitory effects against Cov. This article briefly discusses the nature, symptoms, transmission, treatment, prevention, and protection of this deadly virus.

Phagocytosis and Phagosome Maturation Are Regulated by Calcium in J774 Macrophages Interacting with Unopsonized Prey

2002 ◽  
Vol 22 (5-6) ◽  
pp. 529-540 ◽  
Author(s):  
Katarina Tejle ◽  
Karl-Eric Magnusson ◽  
Birgitta Rasmusson
Keyword(s):  
Leishmania Donovani ◽  
Inhibitory Effect ◽  
Phagosome Maturation ◽  
Calcium Dependent ◽  
Proper Functioning ◽  
Phagosomal Maturation ◽  
Macrophage Phagocytosis ◽  
Dependent Processes

Phagocytosis by neutrophils, macrophages, and other professional phagocytes requires rapid remodeling of actin. Early phagosomes are surrounded by a rim of F-actin that is disassembled during phagosomoal maturation. Breakdown of periphagosomal F-actin and phagolysosome fusion are calcium dependent processes in neutrophils interacting with serum-opsonized prey, but appears to be calcium independent in macrophages interacting with serum- or IgG-opsonized prey. In the present study, we found that calcium was necessary for phagocytosis, breakdown of periphagosomal F-actin, and phagosomal maturation in J774 macrophages interacting with unopsonized prey. We also observed that lipophosphoglycan (LPG) from Leishmania donovani promastigotes required calcium to exert its inhibitory effect on macrophage phagocytosis and periphagosomal F-actin breakdown. We conclude that calcium is essential for phagocytosis, depolymerization of periphagosomal F-actin, and phagosomal maturation in J774 macrophages interacting with unopsonized prey, as well as for proper functioning of LPG.

Effect of yttrium on calcium-dependent processes in vertebrate myocardium

2014 ◽  
Vol 50 (3) ◽  
pp. 221-226 ◽  
Author(s):  
I. V. Shemarova ◽  
K. V. Sobol’ ◽  
S. M. Korotkov ◽  
V. P. Nesterov
Keyword(s):  
Calcium Dependent ◽  
Dependent Processes
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