Pharmacological characterization of alpha-adrenoceptors involved in nictitating membrane and pupillary responses to sympathetic nerve stimulation in cats

1988 ◽  
Vol 337 (1) ◽  
Author(s):  
MichaelC. Koss ◽  
Tseggai Gherezghiher
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Nictitating Membrane ◽  
Sympathetic Nerve Stimulation ◽  
Pharmacological Characterization ◽  
Alpha Adrenoceptors ◽  
Pupillary Responses

scholarly journals Characterization of the ATPase released during sympathetic nerve stimulation of the guinea-pig isolated vas deferens

2000 ◽  
Vol 129 (8) ◽  
pp. 1684-1688 ◽  
Author(s):  
T D Westfall ◽  
S Sarkar ◽  
N Ramphir ◽  
D P Westfall ◽  
P Sneddon ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Vas Deferens ◽  
Sympathetic Nerve Stimulation ◽  
Stimulation Of

Interactive Effects of Verapamil and Sympathetic Nerve Stimulation on the Sinus and AV Nodes in the Canine Hearts.

1992 ◽  
Vol 33 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Katsusuke YANO ◽  
Masanobu HIRATA ◽  
Takao MITSUOKA ◽  
Yoriaki MATSUMOTO ◽  
Tetsuya HIRATA ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Interactive Effects ◽  
Sympathetic Nerve Stimulation

What do antagonists tell us about α-adrenoceptors?

1985 ◽  
Vol 68 (s10) ◽  
pp. 15s-19s ◽  
Author(s):  
G. M. Drew
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Isolated Heart ◽  
Coupling Mechanism ◽  
Sympathetic Nerve Stimulation ◽  
Stimulus Response ◽  
Adrenoceptor Agonist ◽  
Tissue Responses ◽  
Cat Spleen ◽  
Relative Potencies

The early proposals that pre- and post-junctional α-adrenoceptors might be different stemmed largely from two separate observations. Firstly, the orders of potency of a series of agonists at inhibiting the response to sympathetic nerve stimulation and in increasing inotropic activity in the rabbit isolated heart were different [1, 2]. Secondly, phenoxybenzamine was more potent in inhibiting vasoconstrictor responses to sympathetic nerve stimulation than in increasing transmitter overflow from the cat spleen [3]. These experiments illustrate the most fundamental, pharmacological ways of distinguishing between receptors: namely, by comparing the relative potencies of agonists and/or antagonists in producing, or preventing, pharmacological effects. There are, however, difficulties in using agonists to classify receptors because their ability to generate a response depends not only upon their intrinsic properties of affinity for, and efficacy at, the receptors but also upon the capacity of the tissue to translate the stimulus into a response. Thus agonists with a relatively low intrinsic efficacy may produce a small response, or no response at all, in a tissue in which the efficiency of the stimulus-response coupling mechanism is low. The importance of this phenomenon in influencing tissue responses to agonists with low efficacy has been demonstrated for the α-adrenoceptor agonist prenalterol [4] and for the α-adrenoceptor agonist oxymetazoline [5].

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