Cultured chick sympathetic neurons: ATP-induced noradrenaline release and its blockade by nicotinic receptor antagonists

1995 ◽  
Vol 352 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Clemens Allgaier ◽  
Henning Wellmann ◽  
Angelika Schobert ◽  
Gerhart Kurz ◽  
Ivar von Kügelgen
Keyword(s):  
Noradrenaline Release ◽  
Nicotinic Receptor ◽  
Sympathetic Neurons ◽  
Receptor Antagonists

Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents

2004 ◽  
Vol 14 (8) ◽  
pp. 1863-1867 ◽  
Author(s):  
Linda P Dwoskin ◽  
Sangeetha P Sumithran ◽  
Jun Zhu ◽  
A.Gabriela Deaciuc ◽  
Joshua T Ayers ◽  
...  
Keyword(s):  
Tobacco Use ◽  
Nicotinic Receptor ◽  
Receptor Antagonists ◽  
Tobacco Use Cessation ◽  
Subtype Selective

α2-Adrenoceptor-Mediated Inhibition of Electrically Evoked [3H]Noradrenaline Release from Chick Sympathetic Neurons: Role of Cyclic AMP

2002 ◽  
Vol 63 (1) ◽  
pp. 146-154 ◽  
Author(s):  
Stefan Boehm ◽  
Sigismund Huck ◽  
Gabriele Koth ◽  
Helmut Drobny ◽  
Ernst Agneter ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Noradrenaline Release ◽  
Sympathetic Neurons ◽  
Α2 Adrenoceptor

Effects of Buthus martensii Karsch scorpion venom on the release of noradrenaline from in vitro and in vivo rat preparations

1994 ◽  
Vol 72 (8) ◽  
pp. 855-861 ◽  
Author(s):  
Sylvain Foucart ◽  
Rui Wang ◽  
Pierre Moreau ◽  
Rémi Sauvé ◽  
Jacques de Champlain ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Noradrenaline Release ◽  
Sympathetic Neurons ◽  
Scorpion Venom ◽  
Dependent Manner ◽  
Release Of Noradrenaline ◽  
Adult Rat ◽  
Isolated Atria

The aim of this study was to test the neuronal effects of the Chinese Buthus martensii Karsch (BMK) scorpion venom in vivo and in vitro in order to understand the mechanism involved in the cardiovascular pressor effect of this venom. In conscious unrestrained rats, administration of 100 μg/kg i.v. BMK venom induced an increase in blood pressure, which was associated with a significant increase in plasma noradrenaline. In isolated atria, BMK also induced an increase in the stimulation-induced release of [3H]noradrenaline in a dose-dependent manner. The modulatory effect of agents acting at sympathetic prejunctional adrenoceptors on [3H]noradrenaline release was not altered by BMK venom administration. Finally, it was observed that 100 μg/mL BMK venom increased the intracellular calcium concentration in acutely dissociated sympathetic neurons from adult rat superior cervical ganglion. This action appeared to be mainly due to an influx of extracellular calcium. BMK venom induced a small rise in intracellular calcium in the absence of external calcium, indicating that it may also mobilize calcium from intracellular stores. The results observed in this study suggest that BMK venom may induce pressor responses by releasing noradrenaline from the sympathetic nerve terminals and that activation of neuronal calcium channels may be involved in that process.Key words: scorpion venom, noradrenaline release, presynaptic modulation, intracellular calcium.

scholarly journals Identification of a Novel Class of Nicotinic Receptor Antagonists

2006 ◽  
Vol 281 (34) ◽  
pp. 24745-24755 ◽  
Author(s):  
Marion Loughnan ◽  
Annette Nicke ◽  
Alun Jones ◽  
Christina I. Schroeder ◽  
Simon T. Nevin ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Receptor Antagonists

Modulation of electrically evoked [3H]-noradrenaline release from cultured chick sympathetic neurons

1994 ◽  
Vol 350 (3) ◽  
Author(s):  
Clemens Allgaier ◽  
Angelika Schobert ◽  
Manuela Belledin ◽  
Rolf Jackisch ◽  
Georg Hertting
Keyword(s):  
Noradrenaline Release ◽  
Sympathetic Neurons

scholarly journals Indolizidine (−)-235B′ and related structural analogs: Discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release

2011 ◽  
Vol 658 (2-3) ◽  
pp. 132-139 ◽  
Author(s):  
Marharyta Pivavarchyk ◽  
Andrew M. Smith ◽  
Zhenfa Zhang ◽  
Dejun Zhou ◽  
Xu Wang ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Dopamine Release ◽  
Receptor Antagonists

scholarly journals Anti‐angiogenic activity of alpha7‐nicotinic receptor antagonists in human small cell lung cancer

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Brent A Thornhill ◽  
Kathleen C Brown ◽  
Jamie K Lau ◽  
Aaron M Dom ◽  
Theodore R Witte ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Nicotinic Receptor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Receptor Antagonists ◽  
Angiogenic Activity ◽  
Alpha7 Nicotinic Receptor
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