The role of cyclic AMP in the positive inotropic effect mediated by ?1- and ?2-adrenoceptors in isolated human right atrium

1987 ◽  
Vol 335 (5) ◽  
Author(s):  
K. Ikezono ◽  
M.C. Michel ◽  
H.R. Zerkowski ◽  
J.J. Beckeringh ◽  
O.E. Brodde
Keyword(s):  
Cyclic Amp ◽  
Right Atrium ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Human Right ◽  
Human Right Atrium

Age-dependent decrease in the negative inotropic effect of carbachol on isolated human right atrium

1998 ◽  
Vol 357 (2-3) ◽  
pp. 199-202 ◽  
Author(s):  
Christine Giessler ◽  
Thekla Wangemann ◽  
Hans-Reinhard Zerkowski ◽  
Otto-Erich Brodde
Keyword(s):  
Right Atrium ◽  
Negative Inotropic Effect ◽  
Inotropic Effect ◽  
Human Right ◽  
Age Dependent ◽  
Human Right Atrium

Diazepam potentiates the positive inotropic effect of isoprenaline in rat ventricle strips: role of cyclic AMP

1995 ◽  
Vol 282 (1-3) ◽  
pp. 169-175 ◽  
Author(s):  
Ester Martinez ◽  
Rafael Peñafiel ◽  
M.Carmen Collado ◽  
Jesús Hernández
Keyword(s):  
Cyclic Amp ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Rat Ventricle

A 5-HT4-like receptor in human right atrium

1991 ◽  
Vol 344 (2) ◽  
pp. 150-159 ◽  
Author(s):  
Alberto J. Kaumann ◽  
Louise Sanders ◽  
Anthony M. Brown ◽  
Kenneth J. Murray ◽  
Morris J. Brown
Keyword(s):  
Right Atrium ◽  
Human Right ◽  
Human Right Atrium

scholarly journals Urotensin II receptor expression in human right atrium and aorta: effects of ischaemic heart disease

2009 ◽  
Vol 102 (4) ◽  
pp. 477-484 ◽  
Author(s):  
A.D. Leonard ◽  
J.P. Thompson ◽  
E.L. Hutchinson ◽  
S.P. Young ◽  
J. McDonald ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Right Atrium ◽  
Receptor Expression ◽  
Urotensin Ii ◽  
Human Right ◽  
Human Right Atrium

Positive inotropic effect of interleukin-2. Role of phospholipases and protein kinase C

1991 ◽  
Vol 13 (5) ◽  
pp. 509-515 ◽  
Author(s):  
Maria M. de E. de Bracco ◽  
Susana B. Fink ◽  
Marta R. Finiasz ◽  
Enri S. Borda ◽  
Leonor Sterin-Borda
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Positive Inotropic Effect ◽  
Interleukin 2 ◽  
Inotropic Effect ◽  
Kinase C

From cellular automata model of vagal control of the human right atrium to heart beats patterns

2021 ◽  
Vol 415 ◽  
pp. 132771
Author(s):  
Danuta Makowiec ◽  
Wiesław Miklaszewski ◽  
Joanna Wdowczyk ◽  
Anna T. Lawniczak
Keyword(s):  
Cellular Automata ◽  
Right Atrium ◽  
Human Right ◽  
Cellular Automata Model ◽  
Vagal Control ◽  
Human Right Atrium

Role of the Na+ /K+ /Cl? transporter in the positive inotropic effect of ouabain in cardiac myocytes

1990 ◽  
Vol 145 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Rivka Panet ◽  
Ruhama Fixler ◽  
David Snyder ◽  
Shmuel Raz ◽  
Henri Atlan ◽  
...  
Keyword(s):  
Cardiac Myocytes ◽  
Positive Inotropic Effect ◽  
Inotropic Effect

scholarly journals Prostacyclins have no direct inotropic effect on isolated atrial strips from the normal and pressure-overloaded human right heart

2017 ◽  
Vol 7 (2) ◽  
pp. 339-347 ◽  
Author(s):  
Sarah Holmboe ◽  
Asger Andersen ◽  
Rebekka V. Jensen ◽  
Hans Henrik Kimose ◽  
Lars B. Ilkjær ◽  
...  
Keyword(s):  
Right Atrium ◽  
Quantitative Polymerase Chain Reaction ◽  
Organ Bath ◽  
Inotropic Response ◽  
Force Of Contraction ◽  
Human Right ◽  
Prostanoid Receptors ◽  
Right Heart ◽  
Inotropic Effects ◽  
Human Right Atrium

Prostacyclins are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostacyclins on right heart function are still not clarified. The aim of this study was to investigate the possible direct inotropic properties of clinical available prostacyclin mimetics in the normal and the pressure-overloaded human right atrium. Trabeculae from the right atrium were collected during surgery from chronic thromboembolic pulmonary hypertension (CTEPH) patients with pressure-overloaded right hearts, undergoing pulmonary thromboendarterectomy (n = 10) and from patients with normal right hearts operated by valve replacement or coronary bypass surgery (n = 9). The trabeculae were placed in an organ bath, continuously paced at 1 Hz. They were subjected to increasing concentrations of iloprost, treprostinil, epoprostenol, or MRE-269, followed by isoprenaline to elicit a reference inotropic response. The force of contraction was measured continuously. The expression of prostanoid receptors was explored through quantitative polymerase chain reaction (qPCR). Iloprost, treprostinil, epoprostenol, or MRE-269 did not alter force of contraction in any of the trabeculae. Isoprenaline showed a direct inotropic response in both trabeculae from the pressure-overloaded right atrium and from the normal right atrium. Control experiments on ventricular trabeculae from the pig failed to show an inotropic response to the prostacyclin mimetics. qPCR demonstrated varying expression of the different prostanoid receptors in the human atrium. In conclusion, prostacyclin mimetics did not increase the force of contraction of human atrial trabeculae from the normal or the pressure-overloaded right heart. These data suggest that prostacyclin mimetics have no direct inotropic effects in the human right atrium.

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