The release of dopamine from nerve terminals and dendrites of nigrostriatal neurons induced by excitatory amino acids in the conscious rat

1992 ◽  
Vol 345 (5) ◽  
pp. 523-529 ◽  
Author(s):  
B.H.C. Westerink ◽  
M. Santiago ◽  
J.B. De Vries
Keyword(s):  
Amino Acids ◽  
Excitatory Amino Acids ◽  
Nerve Terminals ◽  
Conscious Rat ◽  
Nigrostriatal Neurons

Excitatory Amino Acids Act on the Median Eminence Nerve Terminals to Induce Gonadotropin-Releasing Hormone Release in Female Rats

1998 ◽  
Vol 112 (3) ◽  
pp. 372-382 ◽  
Author(s):  
Shin-ichi Kawakami ◽  
Masumi Ichikawa ◽  
Kumiko Murahashi ◽  
Kanjun Hirunagi ◽  
Hiroko Tsukamura ◽  
...  
Keyword(s):  
Amino Acids ◽  
Median Eminence ◽  
Excitatory Amino Acids ◽  
Gonadotropin Releasing Hormone ◽  
Female Rats ◽  
Nerve Terminals ◽  
Hormone Release ◽  
Releasing Hormone

Baclofen: effects on amino acid release

1978 ◽  
Vol 56 (1) ◽  
pp. 150-154 ◽  
Author(s):  
S. J. Potashner
Keyword(s):  
Amino Acids ◽  
Excitatory Amino Acids ◽  
The Other ◽  
Aminobutyric Acid ◽  
Nerve Terminals ◽  
Amino Butyric Acid ◽  
Acid Release ◽  
Afferent Terminals ◽  
Excitatory Transmitter ◽  
Stimulation Of

This study investigated the effects of the antispastic drug β-(p-chlorophenyl)-γ-amino-butyric acid (Baclofen) on the release of amino acids from slices of guinea pig cerebral cortex. Electrical stimulation of slices evoked the release of endogenous14C-labelled glutamate, aspartate, γ-aminobutyric acid (GABA), alanine, and threonine–serine–glutamine (labelled via metabolism of D-[U-14C]glucose), and of exogenous glutamate, aspartate, GABA, and α-aminoisobutyrate. The releases of endogenous14C-labelled glutamate, aspartate, and GABA were three to seven times larger than those of other amino acids. Baclofen (4 μM) inhibited the evoked release of endogenous 14C-labelled glutamate and aspartate by nearly 60%, that of endogenous14C-labelled threonine–serine–glutamine and alanine by 14–19%, but had no effect on that of endogenous14C-labelled GABA. The drug inhibited the evoked release of the exogenous amino acids by 25–32%. Baclofen doubled the incorporation of 14C from D-[U-14C]glucose into endogenous alanine but was without effect on either the incorporation of 14C into the other endogenous amino acids or the turnover of any of the endogenous14C-labelled amino acids. Because endogenous14C-labelled glutamate, aspartate, and GABA are probably released from nerve terminals, Baclofen selectively suppresses the release of excitatory amino acids from nerve terminals. Similarly, depression of the release of excitatory transmitter (presumably glutamate) from primary afferent terminals in the spinal cord may at least partly explain the antispastic action of Baclofen.

Early cellular swelling during cerebral ischemia in vivo is mediated by excitatory amino acids released from nerve terminals

1992 ◽  
Vol 577 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Yoichi Katayama ◽  
Toru Tamura ◽  
Donald P. Becker ◽  
Takashi Tsubokawa
Keyword(s):  
Amino Acids ◽  
Cerebral Ischemia ◽  
Excitatory Amino Acids ◽  
Nerve Terminals ◽  
Cellular Swelling

Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest

1999 ◽  
Vol 67 (2) ◽  
pp. 371-376 ◽  
Author(s):  
Elaine E Tseng ◽  
Malcolm V Brock ◽  
Christopher C Kwon ◽  
Madhu Annanata ◽  
Mary S Lange ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Amino Acids ◽  
Excitatory Amino Acids ◽  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest
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