Characterization of the sensitivity of cardiac outwardly-rectifying K+ channels to class III antiarrhythmics: the influence of inhibitory sulfonamide derivatives

1995 ◽  
Vol 352 (3) ◽  
Author(s):  
I. Benz ◽  
M. Kohlhardt
Keyword(s):  
Class Iii ◽  
K Channels ◽  
Class Iii Antiarrhythmics

scholarly journals The G-Protein α-Subunit GasC Plays a Major Role in Germination in the Dimorphic FungusPenicillium marneffei

Genetics ◽  
2003 ◽  
Vol 164 (2) ◽  
pp. 487-499 ◽  
Author(s):  
Sophie Zuber ◽  
Michael J Hynes ◽  
Alex Andrianopoulos
Keyword(s):  
G Protein ◽  
Germination Rate ◽  
Yeast Cells ◽  
Class Iii ◽  
Temperature Dependent ◽  
Gene Encoding ◽  
Α Subunit ◽  
G Protein Α Subunit ◽  
Opportunistic Human Pathogen

AbstractThe opportunistic human pathogen Penicillium marneffei exhibits a temperature-dependent dimorphic switch. At 25°, multinucleate, septate hyphae that can undergo differentiation to produce asexual spores (conidia) are produced. At 37° hyphae undergo arthroconidiation to produce uninucleate yeast cells that divide by fission. This work describes the cloning of the P. marneffei gasC gene encoding a G-protein α-subunit that shows high homology to members of the class III fungal Gα-subunits. Characterization of a ΔgasC mutant and strains carrying a dominant-activating gasCG45R or a dominant-interfering gasCG207R allele show that GasC is a crucial regulator of germination. A ΔgasC mutant is severely delayed in germination, whereas strains carrying a dominant-activating gasCG45R allele show a significantly accelerated germination rate. Additionally, GasC signaling positively affects the production of the red pigment by P. marneffei at 25° and negatively affects the onset of conidiation and the conidial yield, showing that GasC function overlaps with functions of the previously described Gα-subunit GasA. In contrast to the S. cerevisiae ortholog Gpa2, our data indicate that GasC is not involved in carbon or nitrogen source sensing and plays no major role in either hyphal or yeast growth or in the switch between these two forms.

ASSA13-06-2 Characterization of Small-Conductance Ca2+-Activated K+Channels in Patients with Chronic Atrial Fibrillation

Heart ◽  
2013 ◽  
Vol 99 (Suppl 1) ◽  
pp. A33.2-A33
Author(s):  
Li Miao-ling ◽  
Li Tao ◽  
Lan Huan ◽  
Mao Liang ◽  
Ou Xian-hong ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chronic Atrial Fibrillation ◽  
K Channels ◽  
Small Conductance

scholarly journals Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

2014 ◽  
Vol 463 (3) ◽  
pp. 413-427 ◽  
Author(s):  
Ruzica Bago ◽  
Nazma Malik ◽  
Michael J. Munson ◽  
Alan R. Prescott ◽  
Paul Davies ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Selective Inhibitor ◽  
Class Iii ◽  
Phosphate Binding ◽  
Downstream Target ◽  
Phosphoinositide 3 Kinase ◽  
Phosphatidylinositol 3

We characterize VPS34-IN, a potent and selective inhibitor of class III Vps34 PI3K. Using VPS34-IN1, we demonstrate that PtdIns(3)P, produced by Vps34 controls phosphorylation and activity of the SGK3 protein kinase.

scholarly journals Chemical Synthesis and Characterization of Maurotoxin, a Short Scorpion Toxin with four Disulfide Bridges that Acts on K+ Channels

1996 ◽  
Vol 242 (3) ◽  
pp. 491-498 ◽  
Author(s):  
Ryadh Kharrat ◽  
Kamel Mabrouk ◽  
Marcel Crest ◽  
Herve Darbon ◽  
Razika Oughideni ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Scorpion Toxin ◽  
Synthesis And Characterization ◽  
Disulfide Bridges ◽  
K Channels

scholarly journals Transcriptome-wide Identification and Characterization of microRNAs and Their Targets in a Highly Adaptable Conifer Platycladus orientalis

2022 ◽  
Vol 147 (1) ◽  
pp. 7-17
Author(s):  
Ying Yang ◽  
Xian-Ge Hu ◽  
Bingsong Zheng ◽  
Yue Li ◽  
Tongli Wang ◽  
...  
Keyword(s):  
Stress Tolerance ◽  
Leucine Zipper ◽  
Class Iii ◽  
Conifer Species ◽  
Essential Information ◽  
Sequencing Platform ◽  
Platycladus Orientalis ◽  
Wide Range ◽  
Identification And Characterization

MicroRNAs (miRNAs) are short noncoding RNAs (20–25 nucleotides) that regulate gene expression posttranscriptionally. However, identification and characterization of miRNAs remain limited for conifer species. In this study, we applied transcriptome-wide miRNAs sequencing to a conifer species Platycladus orientalis, which is highly adaptable to a wide range of environmental adversities, including drought, barren soil, and mild salinity. A total of 17,181,542 raw reads were obtained from the Illumina sequencing platform; 31 conserved and 91 novel miRNAs were identified, and their unique characteristics were further analyzed. Ten randomly selected miRNAs were validated by quantificational real-time polymerase chain reaction. Through miRNA target predictions based on psRNATarget, 2331 unique mRNAs were predicted to be targets of P. orientalis miRNAs that involved in 187 metabolic pathways in KEGG database. These targets included not only important transcription factors (e.g., class III homeodomain leucine zipper targeted by por-miR166d) but also indispensable nontranscriptional factor proteins (i.e., por-miR482a-3p regulated nucleotide-binding site leucine-rich repeat protein). Interestingly, six miRNAs (por-miR16, -miR44, -miR60-5p, -miR69–3p, -miR166b-5p, and -miR395c) were found in adaptation-related pathways (e.g., drought), indicating their possible involved in this species’ stress-tolerance characteristics. The present study provided essential information for understanding the regulatory role of miRNAs in P. orientalis and sheds light on their possible use in tree improvement for stress tolerance.

scholarly journals Functional characterization of a defense-related class-III chitinase promoter from Lupinus albus, active in legume and monocot tissues

2016 ◽  
Vol 146 (4) ◽  
pp. 923-936
Author(s):  
Dean Oelofse ◽  
Inge Gazendam ◽  
Adri Veale ◽  
Arnaud Djami-Tchatchou ◽  
Dave Berger ◽  
...  
Keyword(s):  
Lupinus Albus ◽  
Functional Characterization ◽  
Class Iii ◽  
Class Iii Chitinase

Molecular cloning and characterization of a flower-specific class III peroxidase gene in G. Hirsutum

2007 ◽  
Vol 36 (3) ◽  
pp. 461-469 ◽  
Author(s):  
Dongyan Chen ◽  
Yezhang Ding ◽  
Wangzhen Guo ◽  
Tianzhen Zhang
Keyword(s):  
Molecular Cloning ◽  
Specific Class ◽  
Class Iii ◽  
Peroxidase Gene ◽  
Class Iii Peroxidase
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