Evaluation of the effects of dopexamine, a novel DA1 receptor and ?2-adrenoceptor agonist, on cardiac function and splanchnic circulation in a canine model of hemorrhagic shock

1993 ◽  
Vol 347 (3) ◽  
pp. 296-300 ◽  
Author(s):  
Madhu S. Chintala ◽  
Robert J. Moore ◽  
Mustafa F. Lokhandwala ◽  
Bhagavan S. Jandhyala
Keyword(s):  
Cardiac Function ◽  
Hemorrhagic Shock ◽  
Canine Model ◽  
Splanchnic Circulation ◽  
Adrenoceptor Agonist

Cardiac function during hemorrhagic shock and crystalloid resuscitation

1978 ◽  
Vol 24 (4) ◽  
pp. 235-244 ◽  
Author(s):  
Abi V.S. Rayner ◽  
Glenn E. Lambert ◽  
Robert L. Fulton
Keyword(s):  
Cardiac Function ◽  
Hemorrhagic Shock

scholarly journals Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic

2016 ◽  
Vol 45 (4) ◽  
pp. 686-693 ◽  
Author(s):  
Eilleen S. Y. Ao-ieong ◽  
Alexander Williams ◽  
Vivek Jani ◽  
Pedro Cabrales
Keyword(s):  
Cardiac Function ◽  
Hemorrhagic Shock ◽  
Bovine Hemoglobin

GLUCOSAMINE MAINTAINS CARDIAC FUNCTION AND DOWNREGULATES PROINFLAMMATORY CYTOKINES FOLLOWING TRAUMA-HEMORRHAGIC SHOCK (TH).

Shock ◽  
2004 ◽  
Vol 21 ◽  
pp. 24
Author(s):  
R. B. Marchase ◽  
S. Yang ◽  
S. Hu ◽  
L. Y. Zou ◽  
T. Chang ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Hemorrhagic Shock ◽  
Proinflammatory Cytokines

MAST CELL STABILIZATION AND IMPROVED CARDIAC FUNCTION FOLLOWING HEMORRHAGIC SHOCK

Shock ◽  
2003 ◽  
Vol 19 (Supplement) ◽  
pp. 55
Author(s):  
D. J. Santone ◽  
D. W. Harkin ◽  
A. D. Romaschin ◽  
B. B. Rubin ◽  
T. F. Lindsay
Keyword(s):  
Mast Cell ◽  
Cardiac Function ◽  
Hemorrhagic Shock ◽  
Mast Cell Stabilization ◽  
Cell Stabilization

C-9 HEMODYNAMIC PARAMETERS IN HEMORRHAGIC SHOCK WITH THREE DIFFERENT FORMS OF RESUSCITATION, IN A CANINE MODEL

Shock ◽  
1996 ◽  
Vol 6 ◽  
pp. 21
Author(s):  
CRP Mulinari ◽  
C. B. Ramos ◽  
EJB Ramos ◽  
C D Schmitt ◽  
E Simões ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Canine Model ◽  
Hemodynamic Parameters

Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI

2005 ◽  
Vol 288 (5) ◽  
pp. H2491-H2497 ◽  
Author(s):  
Bing S. Huang ◽  
Frans H. H. Leenen
Keyword(s):  
Cardiac Function ◽  
Left Ventricular ◽  
Coronary Artery Ligation ◽  
Mineralocorticoid Receptors ◽  
Artery Ligation ◽  
Sympathetic Hyperactivity ◽  
Air Jet ◽  
Baroreflex Function ◽  
Adrenoceptor Agonist ◽  
The Brain

In rats post-myocardial infarction (MI), sympathetic hyperactivity can be prevented by blockade of brain mineralocorticoid receptors (MR). Stimulatory responses to central infusion of aldosterone can be blocked by benzamil and therefore appear to be mediated via Na+ channels, presumably epithelial Na+ channels (ENaC), in the brain. To evaluate this concept of endogenous mineralocorticoids in Wistar rats post-MI, we examined effects of blockade of MR and Na+ channels in the brain. At 3 days after coronary artery ligation, intracerebroventricular infusions were started with spironolactone (400 ng·kg−1·h−1) or its vehicle, or with benzamil (4 μg·kg−1·h−1) or its vehicle, using osmotic minipumps. Rats with sham ligation served as control. After 4 wk, in conscious rats, mean arterial pressure, heart rate, and renal sympathetic nerve activity were recorded at rest and in response to air-jet stress, intracerebroventricular injection of the α2-adrenoceptor agonist guanabenz, and intravenous infusion of phenylephrine and nitroprusside for baroreflex function. MI size was similar among the four groups of rats (∼31%). In rats treated post-MI with vehicles, cardiac function was decreased, sympathetic reactivity was enhanced, and baroreflex function was impaired. Blockade of brain Na+ channels or brain MR similarly prevented sympathetic hyperactivity and impairment of baroreflex function and improved cardiac function. These findings suggest that in rats post-MI, increased binding of endogenous agonists to MR increases ENaC activity in the brain and thereby leads to sympathetic hyperactivity and progressive left ventricular dysfunction.

scholarly journals Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin

2020 ◽  
Vol 129 (1) ◽  
pp. 97-107
Author(s):  
Alexander T. Williams ◽  
Alfredo Lucas ◽  
Cynthia R. Muller ◽  
Crystal Bolden-Rush ◽  
Andre F. Palmer ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Hemorrhagic Shock ◽  
Oxygen Transport ◽  
Carrying Capacity ◽  
Blood Viscosity ◽  
Blood Rheology ◽  
Plasma Viscosity ◽  
Bovine Hemoglobin ◽  
Dependent Manner ◽  
Concentration Dependent Manner

Large-molecular diameter polymerized bovine hemoglobin avoided vasoconstriction and impairment of cardiac function during resuscitation from hemorrhagic shock that was seen with previous hemoglobin-based O2 carriers by increasing blood viscosity in a concentration-dependent manner. Supplementation of O2-carrying capacity played a smaller role in maintaining cardiac function than increased blood and plasma viscosity.

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