Involvement of substance P in the excitatory action of GABAA agonists on cholinergic neurons in the guinea-pig ileum

1987 ◽  
Vol 335 (6) ◽  
pp. 629-635 ◽  
Author(s):  
M. Tonini ◽  
L. Onori ◽  
C. A. Rizzi ◽  
E. Perucca ◽  
L. Manzo ◽  
...  
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Cholinergic Neurons ◽  
Guinea Pig Ileum ◽  
Excitatory Action

Somatostatin modulation of peptide-induced acetylcholine release in guinea pig ileum

1984 ◽  
Vol 246 (5) ◽  
pp. G509-G514 ◽  
Author(s):  
D. H. Teitelbaum ◽  
T. M. O'Dorisio ◽  
W. E. Perkins ◽  
T. S. Gaginella
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Longitudinal Muscle ◽  
Guinea Pig Ileum ◽  
Gut Motility ◽  
Release Of Acetylcholine

The peptides caerulein, neurotensin, somatostatin, and substance P modulate the activity of intestinal neurons and alter gut motility. We examined the effects of these peptides on acetylcholine release from the myenteric plexus and intestinal contractility in vitro. Caerulein (1 X 10(-9) M), neurotensin (1.5 X 10(-6) M), and substance P (1 X 10(-7) M) significantly enhanced the release of [3H]acetylcholine from the myenteric plexus of the guinea pig ileum. This effect was inhibited by tetrodotoxin (1.6 X 10(-6) M). Somatostatin (10(-6) M) inhibited caerulein- and neurotensin-evoked release of acetylcholine but did not inhibit release induced by substance P. Caerulein, neurotensin, and substance P caused contraction of the guinea pig ileal longitudinal muscle. Somatostatin inhibited the contractions induced by caerulein and neurotensin. In contrast, substance P-induced contraction was not inhibited significantly by somatostatin. Thus, in the guinea pig ileum, caerulein-, neurotensin-, and substance P-induced contractility is due, at least in part, to acetylcholine release from the myenteric plexus. The ability of somatostatin to inhibit peptide-induced contractility is selective, and its mechanism may be attributed to inhibition of acetylcholine release.

scholarly journals Substance P induces endogenous GABA release from guinea pig ileum

1984 ◽  
Vol 36 ◽  
pp. 87
Author(s):  
Kohtaro Taniyama ◽  
Yukiko Miki ◽  
Masato Kusunoki ◽  
Naoaki Saito ◽  
Chikako Tanaka
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Gaba Release ◽  
Guinea Pig Ileum ◽  
Endogenous Gaba

scholarly journals Modulation of cholinergic and substance P-like neurotransmission by nitric oxide in the guinea-pig ileum

1993 ◽  
Vol 110 (2) ◽  
pp. 833-839 ◽  
Author(s):  
Claes U. Wiklund ◽  
Caroline Olgart ◽  
N. Peter Wiklund ◽  
Lars E. Gustafsson
Keyword(s):  
Nitric Oxide ◽  
Substance P ◽  
Guinea Pig ◽  
Guinea Pig Ileum

Substance P-evoked circular muscle contractions have a close connection with serotonergic neurons in guinea-pig ileum

1993 ◽  
Vol 46 (1-2) ◽  
pp. 379-380
Author(s):  
Toshiaki Ohmori ◽  
Atsukazu Kuwahara ◽  
Tsuyoshi Ozaki ◽  
Noboru Yanaihara ◽  
Yasuo Takeda ◽  
...  
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Circular Muscle ◽  
Muscle Contractions ◽  
Close Connection ◽  
Guinea Pig Ileum ◽  
Serotonergic Neurons
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