Aspergillus niger cyclic AMP levels are not influenced by manganese deficiency and do not correlate with citric acid accumulation

1989 ◽  
Vol 32 (2) ◽  
pp. 124-128 ◽  
Author(s):  
Ding-Bang Xu ◽  
Max R�hr ◽  
Christian P. Kubicek
Keyword(s):  
Citric Acid ◽  
Aspergillus Niger ◽  
Cyclic Amp ◽  
Manganese Deficiency ◽  
Acid Accumulation ◽  
Citric Acid Accumulation

Regulation by zinc and adenosine 3′,5′-cyclic monophosphate of growth and citric acid accumulation in Aspergillus niger

1976 ◽  
Vol 22 (8) ◽  
pp. 1093-1101 ◽  
Author(s):  
William S. M. Wold ◽  
Isamu Suzuki
Keyword(s):  
Citric Acid ◽  
Aspergillus Niger ◽  
Cyclic Amp ◽  
Zinc Deficiency ◽  
Growth Phase ◽  
Acid Fermentation ◽  
High Zinc ◽  
Acid Accumulation ◽  
Camp Metabolism ◽  
Rates Of Growth

The citric acid fermentation by Aspergillus niger is divided into two consecutive phases, growth phase when the cells proliferate but do not accumulate citrate, followed by an accumulating phase when they excrete citrate but do not proliferate. The phase alternative was controlled by the concentration of zinc: high zinc (2 μM) maintained growth phase, and a zinc 'deficiency apparently signaled the transition to the accumulating phase. Cyclic AMP affected the rates of growth and acidogenesis when added to cultures growing at low but not at high zinc: that is, cAMP did not induce the phase transition, zinc deficiency did. Cyclic AMP enhanced growth early in the fermentation, but at later stages the response of the mycelia to cAMP changed, and then cAMP inhibited growth. When citrate eventually began to accumulate cAMP augmented its synthesis. The growth and acidogenic responses were quite specific to cAMP, and were sensitive to concentrations of about 1 μM. Cyclic AMP also either promoted or retarded the appearance of an unidentified yellow pigment. It is proposed that the growth and accumulating phases are distinct differentiated states, at least with respect to cAMP metabolism.

Pyridine nucleotide levels and ratios in Aspergillus niger

1980 ◽  
Vol 26 (3) ◽  
pp. 405-408 ◽  
Author(s):  
L. Führer ◽  
C. P. Kubicek ◽  
M. Röhr
Keyword(s):  
Citric Acid ◽  
Aspergillus Niger ◽  
Filamentous Fungi ◽  
Reliable Method ◽  
Pyridine Nucleotide ◽  
Pyridine Nucleotides ◽  
Metabolic State ◽  
Acid Accumulation ◽  
Reduction Charge ◽  
Citric Acid Accumulation

A reliable method for the extraction and assay of pyridine nucleotides (NAD, NADH, NADP, and NADPH) in filamentous fungi is presented. The method is applied to a study of the physiology of citric acid accumulation by Aspergillus niger. The measurement of "catabolic reduction charge" (NADH/(NAD + NADH)) and "anabolic reduction charge" (NADPH/(NADP + NADPH)) as a means of characterizing the metabolic state is discussed.

Temperature Optima for Citric Acid Accumulation by Aspergillus niger

2002 ◽  
Vol 1 (2) ◽  
pp. 108-110 ◽  
Author(s):  
Asad-ur- Rehman ◽  
Sikander Ali ◽  
Ikram-ul- Haq
Keyword(s):  
Citric Acid ◽  
Aspergillus Niger ◽  
Acid Accumulation ◽  
Temperature Optima ◽  
Citric Acid Accumulation
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