T1 and T2 Proton Nuclear Magnetic Resonance (N.M.R.) relaxation times in vitro and human intracranial tumours

1986 ◽  
Vol 3 (4) ◽  
pp. 315-321 ◽  
Author(s):  
M Chatell ◽  
F Darcel ◽  
J de Certaines ◽  
L Benoist ◽  
AM Bernard
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
Proton Nuclear Magnetic Resonance ◽  
Intracranial Tumours ◽  
T1 And T2 ◽  
Nuclear Magnetic

scholarly journals N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl] quinoline]-acetamide

Molbank ◽  
10.3390/m1213 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1213
Author(s):  
Paolo Coghi ◽  
Jerome P. L. Ng ◽  
Ali Adnan Nasim ◽  
Vincent Kam Wai Wong
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Quantum Coherence ◽  
Biologically Active ◽  
Proton Nuclear Magnetic Resonance ◽  
Dipolar Cycloaddition ◽  
Heteronuclear Single Quantum Coherence ◽  
Pharmacokinetic Properties ◽  
Nuclear Magnetic

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.

Immunosuppressive activity of cyclosporine metabolites compared and characterized by mass spectroscopy and nuclear magnetic resonance

1990 ◽  
Vol 36 (2) ◽  
pp. 225-229 ◽  
Author(s):  
K R Copeland ◽  
R W Yatscoff ◽  
R M McKenna
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Mass Spectroscopy ◽  
Proton Nuclear Magnetic Resonance ◽  
Therapeutic Monitoring ◽  
Potency Ratio ◽  
Transplant Patients ◽  
In Vitro Systems ◽  
Nuclear Magnetic

Abstract Eight cyclosporine (CsA) metabolites were isolated from the urine of renal-transplant patients by high-pressure liquid chromatography. Structure and purity of the metabolites were assessed by fast atomic bombardment/mass spectroscopy, by proton nuclear magnetic resonance (NMR), and, when the quantity of metabolites permitted, by 13C-NMR. The immunosuppressive activities (I) of the metabolites were tested in three separate in vitro systems: primary and secondary mixed lymphocyte reactions as well as by a mitogen-stimulated system. The I, as measured by comparing the concentration of each metabolite required for 50% inhibition of incorporation of [3H] thymidine, varied among the assay systems, as did the ranking of I among the test systems. In general, the I of most metabolites in all assay systems were less than 10% of that for CsA. Metabolites with single modifications exhibited the greatest I; e.g., that of M-17 was congruent to 16% of that of CsA (potency ratio 0.16) in a secondary mixed lymphocyte reaction. The significance of these findings in relation to therapeutic monitoring of CsA is discussed.

In vitro detection of fatty liver infiltration in protein-depleted rats using proton nuclear magnetic resonance

1985 ◽  
Vol 39 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Danny O. Jacobs ◽  
Scott O. Trerotola ◽  
R.Gregg Settle ◽  
Rolando H. Rolandelli ◽  
Gerald L. Wolf ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Fatty Liver ◽  
Proton Nuclear Magnetic Resonance ◽  
Nuclear Magnetic

scholarly journals Characterization of Experimental Ischemic Brain Edema Utilizing Proton Nuclear Magnetic Resonance Imaging

1986 ◽  
Vol 6 (2) ◽  
pp. 212-221 ◽  
Author(s):  
Hiroyuki Kato ◽  
Kyuya Kogure ◽  
Hitoshi Ohtomo ◽  
Masahiro Izumiyama ◽  
Muneshige Tobita ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Water Content ◽  
Relaxation Times ◽  
Nmr Imaging ◽  
Tissue Water Content ◽  
T2 Relaxation ◽  
Tissue Water ◽  
T1 And T2 ◽  
Nuclear Magnetic

Correlations between T1 and T2 relaxation times and water and electrolyte content in the normal and ischemic rat and gerbil brains were studied by means of both nuclear magnetic resonance (NMR) spectroscopic and imaging methods. In the spectroscopic experiment on excised rat brains, T1 was linearly dependent on tissue water content and T2 was prolonged in edematous tissue to a greater extent than expected by an increase in water content, showing that T2 possesses a greater sensitivity for edema identification and localization. Changes in Na+ and K+ content of the tissue mattered little in the prolongation of relaxation times. Serial NMR imaging of gerbil brains insulted with permanent hemispheric ischemia offered early lesion detection in T1- and especially T2-weighted images (detection as soon as 30 min after insult). The progressive nature of lesions was also imaged. Calculated T1 and T2 relaxation times in regions of interest correlated excellently with tissue water content ( r = 0.892 and 0.744 for T1 and T2, respectively). As a result, detection of cerebral ischemia utilizing NMR imaging was strongly dependent on a change in tissue water content. The different nature of T1 and T2 relaxation times was also observed.

Detecting and quantifying organic contaminants in sediments with nuclear magnetic resonance

Geophysics ◽  
2016 ◽  
Vol 81 (6) ◽  
pp. EN87-EN97 ◽  
Author(s):  
Emily L. Fay ◽  
Rosemary J. Knight
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Crude Oil ◽  
Organic Contaminants ◽  
Relaxation Times ◽  
Proton Nuclear Magnetic Resonance ◽  
Bulk Fluid ◽  
Sediment Samples ◽  
Water Signal ◽  
Nuclear Magnetic

We have conducted proton nuclear magnetic resonance (NMR) measurements of relaxation times [Formula: see text] and [Formula: see text] as well as the diffusion coefficient [Formula: see text] to detect and quantify gasoline, diesel, crude oil, and trichloroethylene (TCE) in sediment samples containing water. The sediment samples were coarse sand, fine sand, and a sand-clay mixture. We found that water, gasoline, diesel, and crude oil all exhibited similar signal amplitudes per unit volume, whereas TCE exhibited one-tenth the signal. The ability to use [Formula: see text] measurements to distinguish the contaminant signal from the water signal depended on the bulk-fluid properties as well as the sediment texture and grain size. In the [Formula: see text] distributions for samples containing equal volumes of contaminant and water, the contaminant signal could be resolved for crude oil in sand and for gasoline and TCE in the sand-clay mixture. Adding the diffusion measurement, using either pulsed or static gradients, made it possible to distinguish diesel and crude oil in all of the samples due to the large differences between the [Formula: see text] of the contaminants and water. From the diffusion measurements, we were able to accurately quantify diesel and crude oil volumes ranging from 1% to 17% of the total sample volume. These methods could be applied in the field using NMR logging tools to quantify and monitor subsurface contamination.

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