Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis

1995 ◽  
Vol 42 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Miguel A. Gonzalez-Gay ◽  
Eric Zanelli ◽  
Christopher J. Krco ◽  
Gerald H. Nabozny ◽  
Julie Hanson ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Collagen Induced Arthritis ◽  
Eb Gene

scholarly journals Inflammation and autoimmune responses are independent of peripheral MHC class II expression driven by CIITA pIV in collagen induced arthritis

2011 ◽  
Vol 70 (Suppl 2) ◽  
pp. A25-A25
Author(s):  
J.-M. Waldburger ◽  
G. Palmer ◽  
C. Seemayer ◽  
C. Lamacchia ◽  
A. Finckh ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Collagen Induced Arthritis

Hypomethylation of MHC class II Eb gene is associated with expression

1992 ◽  
Vol 36 (4) ◽  
pp. 255-263 ◽  
Author(s):  
Thomas Scholl ◽  
Amy Pitcock ◽  
Barry Jones
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Eb Gene

Collagen induced arthritis in HLA-DR4/human CD4 transgenic mice lacking mouse MHC class II molecules

1996 ◽  
Vol 47 (1-2) ◽  
pp. 73
Author(s):  
A.P. Cope ◽  
S. Patel ◽  
M. Congia ◽  
L. Fugger ◽  
G. Sonderstrup-McDevitt
Keyword(s):  
Transgenic Mice ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Collagen Induced Arthritis ◽  
Mhc Class Ii Molecules

scholarly journals MHC Class II Derived Recombinant T Cell Receptor Ligands Protect DBA/1LacJ Mice from Collagen-Induced Arthritis

2008 ◽  
Vol 180 (2) ◽  
pp. 1249-1257 ◽  
Author(s):  
Jianya Huan ◽  
Laurie J. Kaler ◽  
Jeffery L. Mooney ◽  
Sandhya Subramanian ◽  
Corwyn Hopke ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Receptor Ligands ◽  
Collagen Induced Arthritis

Identification of MHC Class II and TCR Binding Residues in the Type II Collagen Immunodominant Determinant Mediating Collagen-Induced Arthritis

1996 ◽  
Vol 172 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Edward F. Rosloniec ◽  
Karen B. Whittington ◽  
David D. Brand ◽  
Linda K. Myers ◽  
John M. Stuart
Keyword(s):  
Mhc Class Ii ◽  
Type Ii Collagen ◽  
Class Ii ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Binding Residues

C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells

2012 ◽  
Vol 72 (7) ◽  
pp. 1225-1232 ◽  
Author(s):  
Johan Bäcklund ◽  
Cuiqin Li ◽  
Erik Jansson ◽  
Stefan Carlsen ◽  
Patrick Merky ◽  
...  
Keyword(s):  
T Cell ◽  
Mhc Class Ii ◽  
Collagen Type ◽  
Class Ii ◽  
T Cell Response ◽  
T Cell Epitopes ◽  
Collagen Induced Arthritis ◽  
Histocompatibility Complex ◽  
High Doses ◽  
Arthritis Susceptibility

IntroductionCollagen-induced arthritis (CIA) has traditionally been performed in MHC class II Aq-expressing mice, whereas most genetically modified mice are on the C57BL/6 background (expressing the b haplotype of the major histocompatibility complex (MHC) class II region). However, C57BL/6 mice develop arthritis after immunisation with chicken-derived collagen type II (CII), but arthritis susceptibility has been variable, and the immune specificity has not been clarified.ObjectiveTo establish a CIA model on the C57BL/6 background with a more predictable and defined immune response to CII.ResultsBoth chicken and rat CII were arthritogenic in C57BL/6 mice provided they were introduced with high doses of Mycobacterium tuberculosis adjuvant. However, contaminating pepsin was strongly immunogenic and was essential for arthritis development. H-2b-restricted T cell epitopes on chicken or rat CII could not be identified, but expression of Aq on the C57BL/6 background induced T cell response to the CII260–270 epitope, and also prolonged the arthritis to be more chronic.ConclusionsThe putative (auto)antigen and its arthritogenic determinants in C57BL/6 mice remains undisclosed, questioning the value of the model for addressing T cell-driven pathological pathways in arthritis. To circumvent this impediment, we recommend MHC class II congenic C57BL/6N.Q mice, expressing Aq, with which T cell determinants have been thoroughly characterised.

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