Physical mapping of the human T-cell receptor beta gene complex, using yeast artificial chromosomes

1995 ◽  
Vol 41 (6) ◽  
pp. 337-342 ◽  
Author(s):  
Yasmeen Hashim ◽  
Ioannis Ragoussis ◽  
Lyndal Kearney ◽  
Sabrina Tosi ◽  
Alex K. So
Keyword(s):  
T Cell Receptor ◽  
Physical Mapping ◽  
Cell Receptor ◽  
Gene Complex ◽  
Artificial Chromosomes ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Yeast Artificial Chromosomes ◽  
Beta Gene ◽  
Receptor Beta

Frequent recombination in the human T-cell receptor beta gene complex

1994 ◽  
Vol 39 (5) ◽  
Author(s):  
CamillaE. Day ◽  
Karin Schmitt ◽  
MaryAnn Robinson
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gene Complex ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Beta Gene ◽  
Receptor Beta

scholarly journals A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments.

1994 ◽  
Vol 180 (4) ◽  
pp. 1405-1414 ◽  
Author(s):  
T M Zhao ◽  
S E Whitaker ◽  
M A Robinson
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Homologous Region ◽  
Gene Complex ◽  
Beta Chain ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Genetically Determined ◽  
Receptor Beta

Polymorphism in the human T cell receptor beta chain (TCRB) gene complex includes haplotypes with different numbers of TCRBV genes. An insertion/deletion related polymorphism (IDRP) in the human TCRBV region was found to involve TCRBV gene segments. Inserted TCRB haplotypes contain an additional 21.5 kb in which three TCRBV genes are encoded, members of the TCRBV7, TCRBV9, and TCRBV13 families. Two TCRBV gene segments were present only in inserted haplotypes; one of these, TCRBV7S3, is a functional gene and the other, TCRBV9S2(P), is a pseudogene because of an inframe termination colon. In addition, inserted haplotypes contain two identical copies of the TCRBV13S2 gene, whereas deleted haplotypes have only one copy. Deleted haplotypes could be subdivided into two types, deleted*1 and deleted*2, on the basis of sequence variations in TCRBV6S7 and TCRBV13S2 genes. Both deleted*1 and deleted*2 haplotypes contained the same number of TCRBV genes; both contain 60 genes of which 50 are functional, whereas, inserted haplotypes contained 63 genes of which 52 are functional. Comparisons of inserted region sequences with the homologous region in a deleted haplotype, and with sequences surrounding related TCRBV genes, revealed patterns of similarity that suggest insertion as well as deletion events have occurred in the evolution of the TCRBV gene complex. These data indicate that the genomic TCR repertoire is expanded in individuals who have inserted TCRBV haplotypes. The presence of additional TCRBV genes or, alternatively, the absence of certain TCRBV genes may have an impact upon immune responses and susceptibility to autoimmune diseases.

scholarly journals Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

1996 ◽  
Vol 93 (15) ◽  
pp. 7877-7881 ◽  
Author(s):  
G. Bouvier ◽  
F. Watrin ◽  
M. Naspetti ◽  
C. Verthuy ◽  
P. Naquet ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Cell Development ◽  
Cell Receptor ◽  
Cell Development ◽  
Gene Enhancer ◽  
T Cell Receptor Beta ◽  
Beta Gene ◽  
Receptor Beta

The Human T cell Receptor Beta Variable (TRBV) Genes

2000 ◽  
Vol 17 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Géraldine Folch ◽  
Marie-Paule Lefranc
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Beta Variable ◽  
Receptor Beta

scholarly journals Similar rearrangements of T-cell receptor beta gene in cell lines and uncultured cells from patients with large granular lymphocyte leukemia

Blood ◽  
1988 ◽  
Vol 72 (2) ◽  
pp. 613-615 ◽  
Author(s):  
TP Jr Loughran ◽  
G Starkebaum ◽  
FW Ruscetti
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Lines ◽  
Interleukin 2 ◽  
Cell Receptor ◽  
Large Granular Lymphocyte ◽  
Phenotypic Analysis ◽  
T Cell Receptor Beta ◽  
Beta Gene ◽  
Receptor Beta

Abstract We established interleukin-2-(IL-2) dependent cell lines from three patients with large granular lymphocyte (LGL) leukemia. Phenotypic analysis demonstrated retention of the CD3+, CD8+ phenotype that was observed in the original leukemic LGL. Unique rearrangements of T-cell receptor beta gene occurring in uncultured leukemic LGL, were also found in cell lines, which suggests that the cell lines were derived from the original leukemic LGL clone in each case.

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