Immunohistochemical localization of transforming growth factor ? in the major salivary glands of male and female rats

1993 ◽  
Vol 25 (9) ◽  
pp. 613-618 ◽  
Author(s):  
Howard H. Wu ◽  
Hitoshi Kawamata ◽  
David D. Wang ◽  
Ryoichi Oyasu
Keyword(s):  
Growth Factor ◽  
Salivary Glands ◽  
Transforming Growth Factor ◽  
Immunohistochemical Localization ◽  
Female Rats ◽  
Male And Female ◽  
Major Salivary Glands ◽  
Male And Female Rats

Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats

2018 ◽  
Vol 373 (2) ◽  
pp. 439-457
Author(s):  
Farzana Islam ◽  
Md. Sakirul Islam Khan ◽  
Hiroaki Nabeka ◽  
Shouichiro Saito ◽  
Xuan Li ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Differentially Expressed ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

Immunohistochemical localization and immunoblotting of androgen receptor in spinal neurons of male and female rats

1996 ◽  
Vol 134 (5) ◽  
pp. 626-632 ◽  
Author(s):  
S Lumbroso ◽  
F Sandillon ◽  
V Georget ◽  
JM Lobaccaro ◽  
AO Brinkmann ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Androgen Receptor ◽  
Muscular Atrophy ◽  
Polyclonal Antibodies ◽  
Immunohistochemical Localization ◽  
Female Rats ◽  
Spinal Neurons ◽  
Adult Rats ◽  
Male And Female ◽  
Male And Female Rats

Lumbroso S. Sandillon F, Georget V. Lobaccaro JM, Brinkmann AO, Privat A, Sultan C. Immunohistochemical localization and immunoblotting of androgen receptor in spinal neurons of male and female rats. Eur J Endocrinol 1996:134;626–32. ISSN 0804–4643 Androgen activity in the central nervous system, as in other tissues, is mediated by the androgen receptor. We performed the precise localization of the androgen receptor in spinal cord of male and female adult rats by immunohistochemistry using polyclonal antibodies. Light microscopy indicated immunoreactivity in the anterior horn with a strong staining in motoneurons, but staining was also observed in the posterior horn. Electron microscopy showed a predominant nuclear immunostaining. A weaker but significant immunoreactive androgen receptor was also noted in the perinuclear/ intracysternal position. Moreover, no differences were found between male and female rats. Immuno-blotting demonstrated that the androgen receptor is expressed in both ventral and dorsal spinal cord, with an apparent molecular mass identical to that noted in other androgen-dependent tissues. The expression of androgen receptor in motoneurons corroborates the role of androgens in motoneuron growth, development and regeneration and underlies the possibility that androgen receptor abnormality leads to the motoneuron degeneration observed in X-linked spinal and bulbar muscular atrophy. Charles Sultan, Unité BEDR, Hôpital Lapeyronie, 34295 Montpellier, France

scholarly journals Comparison of membrane phospholipid and its fatty acid compositions of the salivary glands from male and female rats.

1985 ◽  
Vol 27 (1) ◽  
pp. 385-388 ◽  
Author(s):  
Yasunaga Kameyama ◽  
Koji Yashiro ◽  
Masamichi Ohno ◽  
Ryoichi Funabiki ◽  
Takehisa Takenaka ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Salivary Glands ◽  
Female Rats ◽  
Membrane Phospholipid ◽  
Male And Female ◽  
Male And Female Rats ◽  
Fatty Acid Compositions

Gonad-gonadotrope interactions: plasma gonadotrophin levels and tumour induction in long-term castrated rats

1981 ◽  
Vol 97 (2) ◽  
pp. 181-185 ◽  
Author(s):  
Daniel M. Linkie ◽  
Jacob Furth ◽  
Diane Kourelakos
Keyword(s):  
Immunohistochemical Localization ◽  
Female Rats ◽  
Male And Female ◽  
Tumour Induction ◽  
Male And Female Rats ◽  
Specific Radioimmunoassay ◽  
Gonadotrophin Secretion ◽  
Males And Females

Abstract. The patterns of gonadotrophin secretion in intact controls and in male and female rats castrated for up to 36 months were established utilizing specific radioimmunoassay methods. Plasma LH increased 14– 16-fold and FSH rose 4–8-fold in rats of either sex in the first 30 days following gonadectomy. The subsequent 30 day interval showed an additional 76% increase of LH in both sexes and increases in FSH of 32 and 61% in males and females, respectively. These levels were maintained for an additional 34 months. The number of hypophyseal gonadotrophin containing cells, studied by immunohistochemical localization techniques, increased following gonad removal in a pattern similar to that for the circulating hormones. Development of gonadotrophin secreting tumours did not correlate with plasma gonadotrophin concentrations which suggests that the gonadotropes are uniquely resistant to tumourogenesis unlike mammotropes, thyrotropes, and corticotropes.

Growth hormone regulates the rodent hepatic epidermal growth factor receptor at a pretranslational level

1989 ◽  
Vol 3 (2) ◽  
pp. 113-120 ◽  
Author(s):  
S. Johansson ◽  
B. Husman ◽  
G. Norstedt ◽  
G. Andersson
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Female Rats ◽  
Male Rats ◽  
Intact Male ◽  
Male And Female ◽  
Male And Female Rats ◽  
Epidermal Growth

ABSTRACT Recent studies have implicated the involvement of pituitary factor(s) in the regulation of hepatic epidermal growth factor receptor (EGF-R) levels. In the present study the possible role of GH as a regulator of EGF-R has been examined by measuring hepatic EGF-R mRNA and EGF binding in intact and GH-deficient rats and mice before and after administration of GH. Using a human EGF-R probe, 10·5 and 6·0 kb transcripts were detected in mouse and rat liver by Northern gel analysis. EGF-R mRNA was quantified by solution hybridization, and EGF binding determined by incubation of 125I-labelled EGF with a low-density membrane fraction. Levels of hepatic EGF-R mRNA and binding of EGF in female rats were about two-thirds of those in male rats. GH-deficient (lit/lit) male and female mice had approximately 10 and 25% respectively of the levels of EGF-R mRNA and EGF binding of intact male and female mice. Furthermore, hypophysectomized rats exhibited a reduced level of EGF-R mRNA and EGF binding, corresponding to about 20% of the levels detected in intact male rats. When hypophysectomized male and female rats received recombinant human GH (hGH) either as intermittent injections or by continuous infusion using osmotic minipumps, the EGF-R mRNA and EGF binding levels increased to about half those of the intact male animals. No differences between intermittent or continuous administration of hGH on the induction of EGF-R mRNA or EGF binding could be seen. The correlation between mRNA and binding levels suggests regulation at a pretranslational level. There was a reduction of EGF-R mRNA to female levels when intact male rats were given hGH. An additional reduction of EGF binding levels was seen in both intact male and female rats exposed continuously to GH. This may indicate additional translational and/or post-translational regulatory mechanisms.

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