Scale-up of the enantioselective reaction for the enzymatic resolution of (R,S)-ibuprofen

M. Trani; A. Ducret; P. Pepin; R. Lortie

doi:10.1007/bf00143108

Scale-up of the enantioselective reaction for the enzymatic resolution of (R,S)-ibuprofen

Biotechnology Letters ◽

10.1007/bf00143108 ◽

1995 ◽

Vol 17 (10) ◽

pp. 1095-1098 ◽

Cited By ~ 25

Author(s):

M. Trani ◽

A. Ducret ◽

P. Pepin ◽

R. Lortie

Keyword(s):

Scale Up ◽

Enzymatic Resolution ◽

Enantioselective Reaction

Download Full-text

Optimization and Scale-Up of a Lipase-Catalyzed Enzymatic Resolution of an Indole Ester Intermediate for a Prostaglandin D2(DP) Receptor Antagonist Targeting Allergic Rhinitis

Organic Process Research & Development ◽

10.1021/op050261z ◽

2006 ◽

Vol 10 (3) ◽

pp. 592-598 ◽

Cited By ~ 9

Author(s):

Matthew D. Truppo ◽

Michel Journet ◽

Ali Shafiee ◽

Jeffrey C. Moore

Keyword(s):

Allergic Rhinitis ◽

Receptor Antagonist ◽

Scale Up ◽

Prostaglandin D2 ◽

Enzymatic Resolution

Download Full-text

Enzymatic resolution of γ-carboxy-DL-glutamic acid

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19842562 ◽

1984 ◽

Vol 49 (11) ◽

pp. 2562-2565 ◽

Cited By ~ 8

Author(s):

Václav Čeřovský ◽

Karel Jošt

Keyword(s):

Glutamic Acid ◽

Optically Active ◽

Protecting Groups ◽

Subsequent Removal ◽

Enzymatic Resolution ◽

Enantioselective Reaction

Optically active γ-carboxy-L-glutamic acid was prepared by enantioselective reaction of benzyloxycarbonyl-γ-carboxy-DL-glutamic acid with phenylhydrazine, catalyzed by papain (E.C.3.4.22.2), and subsequent removal of the protecting groups from the obtained benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide.

Download Full-text

NiAl precipitation in Fe-12w/o Cr-5w/o Ni-4w/o Al

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010007480x ◽

1983 ◽

Vol 41 ◽

pp. 202-203

Author(s):

L.E. Murr ◽

J.S. Dunning ◽

S. Shankar

Keyword(s):

Solid Solution ◽

Stainless Steel ◽

Stainless Steels ◽

Alloy Composition ◽

Chromium Content ◽

Scale Up ◽

Optical Metallography ◽

Property Evaluation ◽

310 Stainless Steel ◽

Microstructural Studies

Aluminum additions to conventional 18Cr-8Ni austenitic stainless steel compositions impart excellent resistance to high sulfur environments. However, problems are typically encountered with aluminum additions above about 1% due to embrittlement caused by aluminum in solid solution and the precipitation of NiAl. Consequently, little use has been made of aluminum alloy additions to stainless steels for use in sulfur or H2S environments in the chemical industry, energy conversion or generation, and mineral processing, for example.A research program at the Albany Research Center has concentrated on the development of a wrought alloy composition with as low a chromium content as possible, with the idea of developing a low-chromium substitute for 310 stainless steel (25Cr-20Ni) which is often used in high-sulfur environments. On the basis of workability and microstructural studies involving optical metallography on 100g button ingots soaked at 700°C and air-cooled, a low-alloy composition Fe-12Cr-5Ni-4Al (in wt %) was selected for scale up and property evaluation.

Download Full-text