Intracellular lactate dehydrogenase concentration as an index of cytotoxicity in rat hepatocyte primary culture

1988 ◽  
Vol 4 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Eddie S. Chao ◽  
Deborah Dunbar ◽  
Laurence S. Kaminsky
Keyword(s):  
Lactate Dehydrogenase ◽  
Primary Culture ◽  
Rat Hepatocyte ◽  
Hepatocyte Primary Culture

Evaluation of Cichorium Extract for the Growth Supporting Property in Rat Hepatocyte Primary Culture

2007 ◽  
Vol 6 (2) ◽  
pp. 431-434 ◽  
Author(s):  
Tarique Noorul Hasan ◽  
S. Naveed Ahmed ◽  
S.M. Musheer Aalam ◽  
Chandan Kumar ◽  
Gowhar Shafi
Keyword(s):  
Primary Culture ◽  
Rat Hepatocyte ◽  
Hepatocyte Primary Culture

scholarly journals Comparative acute cytotoxicities of 37 xenobiotics detected in drinking water to rat hepatocyte primary culture.

Eisei kagaku ◽  
1990 ◽  
Vol 36 (4) ◽  
pp. 267-276 ◽  
Author(s):  
JUNICHIRO MURAYAMA ◽  
MAKI ISHIWATA ◽  
MIDORI FUKUI ◽  
HIDEO UTSUMI ◽  
AKIRA HAMADA
Keyword(s):  
Drinking Water ◽  
Primary Culture ◽  
Rat Hepatocyte ◽  
Hepatocyte Primary Culture

scholarly journals IL-1β and IL-6 modulate apolipoprotein E gene expression in rat hepatocyte primary culture

1992 ◽  
Vol 1 (5) ◽  
pp. 329-333 ◽  
Author(s):  
Agnes Ribeiro ◽  
Marise Mangeney ◽  
Isabelle Bernard ◽  
Jean Chambaz ◽  
Francisco Delers
Keyword(s):  
Gene Expression ◽  
Primary Culture ◽  
Inflammatory Cytokines ◽  
Acute Phase Response ◽  
Rat Hepatocytes ◽  
Rat Hepatocyte ◽  
Apolipoprotein E Gene ◽  
Cultured Rat Hepatocytes ◽  
Apoe Mrna ◽  
Hepatocyte Primary Culture

Incubation of rat hepatocytes in primary culture with IL-1β at a concentration of 2.5 units/ml resulted in an increase (+80%) in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml) induced a decrease (−35%) in the amount of apoE mRNA, but increased apoE synthesis (+28%). No effect was observed with higher concentrations of IL-1β (10 units/ml) or IL-6 (100 units/ml). These results suggest that inflammatory cytokines IL-1β and IL-6 modulate the expression of apoE gene in cultured rat hepatocytes, at a concentration that does not induce the acute phase response.

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