A hydrophylic polymer system enhanced articular cartilage regeneration in vivo

1995 ◽  
Vol 6 (12) ◽  
pp. 768-772 ◽  
Author(s):  
N. Reissis ◽  
M. Kayser ◽  
G. Bentley ◽  
S. Downes
Keyword(s):  
Articular Cartilage ◽  
Polymer System ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

In vivo articular cartilage regeneration through infrapatellar adipose tissue derived stem cell in nanofiber polycaprolactone scaffold

2019 ◽  
Vol 57 ◽  
pp. 49-56 ◽  
Author(s):  
Parviz Vahedi ◽  
Seyedhosein Jarolmasjed ◽  
Hajar Shafaei ◽  
Leila Roshangar ◽  
Jafar Soleimani Rad ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

A Novel Double-Network Hydrogel Induces Spontaneous Articular Cartilage Regeneration in vivo in a Large Osteochondral Defect

2008 ◽  
Vol 9 (4) ◽  
pp. 307-316 ◽  
Author(s):  
Kazunori Yasuda ◽  
Nobuto Kitamura ◽  
Jian Ping Gong ◽  
Kazunobu Arakaki ◽  
Hyuck Joon Kwon ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Osteochondral Defect ◽  
Cartilage Regeneration ◽  
Double Network ◽  
Articular Cartilage Regeneration

scholarly journals Autologous nasal chondrocytes delivered by injectable hydrogel for in vivo articular cartilage regeneration

2017 ◽  
Vol 19 (1) ◽  
pp. 35-46 ◽  
Author(s):  
Wenliang Chen ◽  
Changhua Li ◽  
Maoxiu Peng ◽  
Bingju Xie ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Injectable Hydrogel ◽  
Articular Cartilage Regeneration

Materials for Articular Cartilage Regeneration

2012 ◽  
Vol 5 (3) ◽  
pp. 187-199 ◽  
Author(s):  
Aysegul Tombuloglu ◽  
Ayse B. Tekinay ◽  
Mustafa O. Guler
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

Combined Effects of Bone Marrow-Derived Mesenchymal Stem Cells and PLGA-PEG-PLGA Scaffolds on Repair of Articular Cartilage Defect

2013 ◽  
Vol 815 ◽  
pp. 345-349 ◽  
Author(s):  
Ching Wen Hsu ◽  
Ping Liu ◽  
Song Song Zhu ◽  
Feng Deng ◽  
Bi Zhang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Growth Factor ◽  
Cartilage Defect ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
Cartilage Defects

Here we reported a combined technique for articular cartilage repair, consisting of bone arrow mesenchymal stem cells (BMMSCs) and poly (dl-lactide-co-glycolide-b-ethylene glycol-b-dl-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers carried with tissue growth factor (TGF-belat1). In the present study, BMMSCs seeded on PLGA-PEG-PLGA with were incubated in vitro, carried or not TGF-belta1, Then the effects of the composite on repair of cartilage defect were evaluated in rabbit knee joints in vivo. Full-thickness cartilage defects (diameter: 5 mm; depth: 3 mm) in the patellar groove were either left empty (n=18), implanted with BMMSCs/PLGA (n=18), TGF-belta1 modified BMMSCs/PLGA-PEG-PLGA. The defect area was examined grossly, histologically at 6, 24 weeks postoperatively. After implantation, the BMMSCs /PLGA-PEG-PLGA with TGF-belta1 group showed successful hyaline-like cartilage regeneration similar to normal cartilage, which was superior to the other groups using gross examination, qualitative and quantitative histology. These findings suggested that a combination of BMMSCs/PLGA-PEG-PLGA carried with tissue growth factor (TGF-belat1) may be an alternative treatment for large osteochondral defects in high loading sites.

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