Malignant progression of B16 melanoma cells induced in vitro by growth factors produced by highly malignant cells

1995 ◽  
Vol 13 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Christopher W. Stackpole ◽  
Laura Groszek ◽  
Suraj S. Kalbag
Keyword(s):  
Growth Factors ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Malignant Progression ◽  
Malignant Cells ◽  
B16 Melanoma Cells

Exercise effects on lung tumor metastases and in vitro alveolar macrophage antitumor cytotoxicity

1998 ◽  
Vol 274 (5) ◽  
pp. R1454-R1459 ◽  
Author(s):  
J. M. Davis ◽  
M. L. Kohut ◽  
D. A. Jackson ◽  
L. H. Colbert ◽  
E. P. Mayer ◽  
...  
Keyword(s):  
Alveolar Macrophage ◽  
Prolonged Exercise ◽  
Lung Tumor ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Intravenous Injections ◽  
B16 Melanoma Cells ◽  
Strong Trend ◽  
Tumor Metastases

This study examined the effects of moderate and prolonged exercise on 1) lung tumor metastases and 2) alveolar macrophage antitumor response in vitro. C57Bl/6 mice were assigned to either Ex-30 (30-min run), Ex-F (run to fatigue), Ex-F-24 h (run to fatigue 24 h before tumor injection), or Con (rested in lanes above the treadmill). Mice received intravenous injections of syngeneic B16 melanoma cells 30 min postexercise. Lungs were removed 7 or 10 days later, and tumor foci were counted. Ex-F had fewer tumors than either Ex-30 or Con, whereas Ex-F-24 h also showed a strong trend toward fewer tumors. The initial localization of tumor cells in the lungs after injection was not different among groups. For the in vitro experiment, mice were killed immediately after exercise or 8 h later. Alveolar macrophages were removed and cultured in vitro with B16 melanoma cells. The growth of the tumors cultured with macrophages from Ex-F was lower than Con after exercise and, to a lesser extent, 8 h later. In Ex-30, this effect was only found immediately after exercise. The data suggest that prolonged exercise has a protective effect on lung tumor metastases and enhances alveolar macrophage antitumor cytotoxicity.

Cytotoxic effect of RA233 on hypoxic B16 melanoma cells in vitro

1988 ◽  
Vol 42 (1-2) ◽  
pp. 127-131 ◽  
Author(s):  
C.W. Stackpole ◽  
R.A. Omar ◽  
D.M. Fornabaio ◽  
Y.S. Kim
Keyword(s):  
Cytotoxic Effect ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

In vitro and in vivo Enhancement of Vincristine Antitumor Activity on B16 Melanoma Cells by Calcium Antagonist Flunarizine

Oncology ◽  
1987 ◽  
Vol 44 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Alberto Bellelli ◽  
Claudia Camboni ◽  
Giovanna de Luca ◽  
Mario Materazzi ◽  
Manlio Mattioni ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
Antitumor Activity ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study

2008 ◽  
Vol 46 (5) ◽  
pp. 1825-1833 ◽  
Author(s):  
Lj. Harhaji ◽  
S. Mijatović ◽  
D. Maksimović-Ivanić ◽  
I. Stojanović ◽  
M. Momčilović ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Coriolus Versicolor ◽  
In Vivo Study ◽  
B16 Melanoma Cells

Artocarpus Plants as a Potential Source of Skin Whitening Agents

2011 ◽  
Vol 6 (9) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Enos Tangke Arung ◽  
Kuniyoshi Shimizu ◽  
Ryuichiro Kondo
Keyword(s):  
Inhibitory Activity ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Vitro Assay ◽  
Skin Whitening ◽  
Melanin Formation ◽  
B16 Melanoma Cells ◽  
Structure Activity

Artocarpus plants have been a focus of constant attention due to the potential for skin whitening agents. In the in vitro experiment, compounds from the Artocarpus plants, such as artocarpanone, norartocarpetin, artocarpesin, artogomezianol, andalasin, artocarbene, and chlorophorin showed tyrosinase inhibitory activity. Structure-activity investigations revealed that the 4-substituted resorcinol moiety in these compounds was responsible for their potent inhibitory activities on tyrosinase. In the in vitro assay, using B16 melanoma cells, the prenylated polyphenols isolated from Artocarpus plants, such as artocarpin, cudraflavone C, 6-prenylapigenin, kuwanon C, norartocarpin, albanin A, cudraflavone B, and brosimone I showed potent inhibitory activity on melanin formation. Structure-activity investigations revealed that the introduction of an isoprenoid moiety to a non-isoprenoid-substituted polyphenol enhanced the inhibitory activity of melanin production in B16 melanoma cells. In the in vivo investigation, the extract of the wood of Artocarpus incisus and a representative isolated compound from it, artocarpin had a lightening effect on the skin of guinea pigs’ backs. Other in vivo experiments using human volunteers have shown that water extract of Artocarpus lakoocha reduced the melanin formation in the skin of volunteers. These results indicate that the extracts of Artocarpus plants are potential sources for skin whitening agents.

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