Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression

1995 ◽  
Vol 13 (4) ◽  
pp. 303-314 ◽  
Author(s):  
David Muir
Keyword(s):  
Schwann Cell ◽  
Matrix Metalloproteinase ◽  
Cell Cultures ◽  
Proliferation And Invasion

scholarly journals Cerebellar granule cells contain a membrane mitogen for cultured Schwann cells.

1989 ◽  
Vol 108 (2) ◽  
pp. 607-611 ◽  
Author(s):  
P W Mason ◽  
J W Bigbee ◽  
G H DeVries
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Schwann Cells ◽  
Cell Cultures ◽  
Granule Cell ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Proteoglycan Synthesis ◽  
Cerebellar Granule ◽  
Mitogenic Signal

Proliferation of Schwann cells is one of the first events that occurs after contact with a growing axon. To further define the distribution and properties of this axonal mitogen, we have (a) cocultured cerebellar granule cells, which lack glial ensheathment in vivo with Schwann cells; and (b) exposed Schwann cell cultures to isolated granule cell membranes. Schwann cells cocultured with granule cells had a 30-fold increase in the labeling index over Schwann cells cultured alone, suggesting that the mitogen is located on the granule cell surface. Inhibition of granule cell proteoglycan synthesis caused a decrease in the granule cells' ability to stimulate Schwann cell proliferation. Membranes isolated from cerebellar granule cells when added to Schwann cell cultures caused a 45-fold stimulation in [3H]thymidine incorporation. The granule cell mitogenic signal was heat and trypsin sensitive and did not require lysosomal processing by Schwann cells to elicit its proliferative effect. The ability of granule cells and their isolated membranes to stimulate Schwann cell proliferation suggests that the mitogenic signal for Schwann cells is a ubiquitous factor present on all axons regardless of their ultimate state of glial ensheathment.

Enrichment of Schwann cell cultures from neonatal rat sciatic nerve by differential adhesion

1981 ◽  
Vol 207 (2) ◽  
pp. 433-444 ◽  
Author(s):  
B.Q. Kreider ◽  
A. Messing ◽  
H. Doan ◽  
S.U. Kim ◽  
R.P. Lisak ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Schwann Cell ◽  
Cell Cultures ◽  
Neonatal Rat ◽  
Rat Sciatic Nerve ◽  
Differential Adhesion

α-Sialyl cholesterol increases laminin in Schwann cell cultures and attenuates cytostatic drug-induced reduction of laminin

1994 ◽  
Vol 654 (1) ◽  
pp. 118-128 ◽  
Author(s):  
Pierre N.M. Konings ◽  
Ria L.A. Philipsen ◽  
Gerrit H. Veeneman ◽  
GéS.F. Ruigt
Keyword(s):  
Schwann Cell ◽  
Cell Cultures ◽  
Cytostatic Drug ◽  
Drug Induced

Efficacy of Various Durations of In Vitro Predegeneration on the Cell Count and Purity of Rat Schwann-Cell Cultures

2010 ◽  
Vol 27 (1) ◽  
pp. 197-203 ◽  
Author(s):  
Armin Kraus ◽  
Joachim Täger ◽  
Konrad Kohler ◽  
Theodora Manoli ◽  
Max Haerle ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Cell Count ◽  
Cell Cultures

Establishment of Schwann cell cultures from adult rat peripheral nerves

1988 ◽  
Vol 102 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Elio Scarpini ◽  
Barbara Q. Kreider ◽  
Robert P. Lisak ◽  
David E. Pleasure
Keyword(s):  
Schwann Cell ◽  
Cell Cultures ◽  
Peripheral Nerves ◽  
Adult Rat

Establishment of Adult Rat Schwann Cell Cultures: Effect of b-FGF, α-MSH, NGF, PDGF, and TGF-β on Cell Cycle

1994 ◽  
Vol 214 (2) ◽  
pp. 543-550 ◽  
Author(s):  
P. Peulve ◽  
A. Laquerriere ◽  
M. Paresy ◽  
J. Hemet ◽  
M. Tadie
Keyword(s):  
Cell Cycle ◽  
Schwann Cell ◽  
Cell Cultures ◽  
Adult Rat
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