Solid-phase synthesis of tailed cyclic peptides: The use of α-allyl-protected aspartic acid leads to aspartimide and tetramethylguanidinium formation

1996 ◽  
Vol 3 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Dominique Delforge ◽  
Marc Dieu ◽  
Edouard Delaive ◽  
Muriel Art ◽  
Barbara Gillon ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Cyclic Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

scholarly journals Solid-phase synthesis of biaryl cyclic peptides containing a histidine-tyrosine linkage

Tetrahedron ◽  
2019 ◽  
Vol 75 (18) ◽  
pp. 2625-2636 ◽  
Author(s):  
Iteng Ng-Choi ◽  
Àngel Oliveras ◽  
Marta Planas ◽  
Lidia Feliu
Keyword(s):  
Cyclic Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides

1993 ◽  
Vol 34 (10) ◽  
pp. 1549-1552 ◽  
Author(s):  
Steven A. Kates ◽  
Nuria A. Solé ◽  
Charles R. Johnson ◽  
Derek Hudson ◽  
George Barany ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Three Dimensional ◽  
Phase Synthesis

Solid Phase Synthesis of Novel Fullerene Nucleotides Conjugates

2011 ◽  
Vol 266 ◽  
pp. 200-203
Author(s):  
Jing Zhang ◽  
Ya Dong Zhang
Keyword(s):  
Aspartic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Properties ◽  
Azomethine Ylide ◽  
Hydroxyl Group ◽  
Spectrometric Analysis ◽  
Phase Synthesis ◽  
Chemical Structures ◽  
Controlled Pore Glass

N-substituted 3, 4-fullero pyrrolidine was synthesized according to 1, 3-dipolar cycloaddition of the azomethine ylide. Aspartic acid with protected α-amino and α-carboxyl groups was reacted with the activated hydroxyl group of N-substituted 3, 4-fullero pyrrolidine. The products were deprotected, affording the monofullerene aspartic acid (mFas). The conjugate FasT was synthesized by reaction of mFas containing protected amino group with the thymidylic acid derivatived controlled pore glass (CPG) using solid phase synthesis. All of the above fullerene derivatives were characterized by UV–vis, 1H NMR, IR and MS spectrometric analysis, giving the correct spectra with regard to their chemical structure. The chemical structures of fullerene nucleotides conjugate FasT is different from previous reports and may have novel biological properties. Moreover, they are more suitable for applications in biomedical research due to their solubilization in THF and DMSO. They have a potential to be used as monomer for the automatic synthesis. It allows further conjugation with specific biomolecules including amino acids, peptides, nucleotides and nucleic acids. A novel method has been developed to synthesize fullerene nucleotides conjugate. Their unique chemical structures make them very interesting for their potential use in medicine and biology.

ChemInform Abstract: Homodetic Cyclic Peptides via Solid-Phase Synthesis

ChemInform ◽  
2010 ◽  
Vol 31 (28) ◽  
pp. no-no
Author(s):  
Christopher Blackburn ◽  
Steven A. Kates
Keyword(s):  
Cyclic Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Solid-phase synthesis of linear and cyclic peptides containing a calix[4]arene amino acid

2009 ◽  
Vol 50 (26) ◽  
pp. 3450-3453 ◽  
Author(s):  
Laura Baldini ◽  
Francesco Sansone ◽  
Federico Scaravelli ◽  
Chiara Massera ◽  
Alessandro Casnati ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cyclic Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Solid-phase synthesis of potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere

1999 ◽  
Vol 40 (14) ◽  
pp. 2729-2732 ◽  
Author(s):  
Jinglan Zhou ◽  
Andreas Termin ◽  
Melissa Wayland ◽  
Christine M. Tarby
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Acid Protease ◽  
Phase Synthesis

Automated Solid-Phase Synthesis of Cyclic Peptides Bearing a Side-Chain Tail Designed for Subsequent Chemical Grafting

1996 ◽  
Vol 242 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Dominique Delforge ◽  
Muriel Art ◽  
Barbara Gillon ◽  
Marc Dieu ◽  
Edouard Delaive ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Side Chain ◽  
Phase Synthesis ◽  
Chemical Grafting ◽  
Subsequent Chemical
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