The regulatory switch of the muscle thin filament: Ca2+ or myosin heads?

1994 ◽  
Vol 15 (3) ◽  
Author(s):  
SherwinS. Lehrer
Keyword(s):  
Thin Filament ◽  
Muscle Thin Filament

scholarly journals 1P144 The Troponin Globular Portion Binding Domain of Tropomyosin is Critical for Ca^-Dependent Regularion of Striated Muscle Thin Filament

2004 ◽  
Vol 44 (supplement) ◽  
pp. S65
Author(s):  
A. Sakuma ◽  
Y. Shitaka ◽  
C. kimura ◽  
K. Sakiyama ◽  
M. Miki
Keyword(s):  
Thin Filament ◽  
Striated Muscle ◽  
Binding Domain ◽  
Muscle Thin Filament

scholarly journals Ca2+ Regulation of Rabbit Skeletal Muscle Thin Filament Sliding: Role of Cross-Bridge Number

2003 ◽  
Vol 85 (3) ◽  
pp. 1775-1786 ◽  
Author(s):  
Bo Liang ◽  
Ying Chen ◽  
Chien-Kao Wang ◽  
Zhaoxiong Luo ◽  
Michael Regnier ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thin Filament ◽  
Rabbit Skeletal Muscle ◽  
Cross Bridge ◽  
Muscle Thin Filament ◽  
Bridge Number

scholarly journals Cardiac muscle thin filament structures reveal calcium regulatory mechanism

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yurika Yamada ◽  
Keiichi Namba ◽  
Takashi Fujii
Keyword(s):  
Cardiac Muscle ◽  
Actin Filament ◽  
Conformational Changes ◽  
Thin Filament ◽  
Structural Changes ◽  
Troponin I ◽  
Regulatory Mechanism ◽  
Troponin T ◽  
Terminal Region ◽  
Muscle Thin Filament

AbstractContraction of striated muscles is driven by cyclic interactions of myosin head projecting from the thick filament with actin filament and is regulated by Ca2+ released from sarcoplasmic reticulum. Muscle thin filament consists of actin, tropomyosin and troponin, and Ca2+ binding to troponin triggers conformational changes of troponin and tropomyosin to allow actin-myosin interactions. However, the structural changes involved in this regulatory mechanism remain unknown. Here we report the structures of human cardiac muscle thin filament in the absence and presence of Ca2+ by electron cryomicroscopy. Molecular models in the two states built based on available crystal structures reveal the structures of a C-terminal region of troponin I and an N-terminal region of troponin T in complex with the head-to-tail junction of tropomyosin together with the troponin core on actin filament. Structural changes of the thin filament upon Ca2+ binding now reveal the mechanism of Ca2+ regulation of muscle contraction.

scholarly journals Role of Actin C-Terminus in Regulation of Striated Muscle Thin Filament

2008 ◽  
Vol 94 (4) ◽  
pp. 1341-1347 ◽  
Author(s):  
Masłgorzata Śliwińska ◽  
Radosław Skórzewski ◽  
Joanna Moraczewska
Keyword(s):  
Thin Filament ◽  
Striated Muscle ◽  
C Terminus ◽  
Muscle Thin Filament
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